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An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells
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“More recently, genetic barcoding compatible with single-cell RNA sequencing (scRNA-seq) has provided information on the cellular output of hundreds of stem cell clones together with cell-state information on the stem cell itself8–12.”
From Clonal tracing with somatic epimutations reveals dynamics of blood ageing (2025) · cites this paper as [11]
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Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
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Single-cell sequencing to multi-omics: technologies and applications
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Temporal modelling using single-cell transcriptomics
Ding, J., Sharon, N., & Bar-Joseph, Z. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00444-7 · Cited by 195
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Self-citationUnraveling Hematopoiesis through the Lens of Genomics
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Metadata
- Authors
- Bowling, S., Sritharan, D., Osorio, F. G., Nguyen, M., Cheung, P., Rodriguez-Fraticelli, A., Patel, S., Yuan, W.-C., Fujiwara, Y., Li, B. E., Orkin, S. H., Hormoz, S., & Camargo, F. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 181
- Issue
- 6
- Pages
- 1410-1422.e27
- ISSN
- 0092-8674
- PMC
- PMC7529102
- Cited by
- 326
- References
- 10
- Language
- en
- Update notices
- erratum (2020-06-25)
- Licence
- Funders
- Howard Hughes Medical Institute
- European Molecular Biology Organization
- Leukemia and Lymphoma Society
- National Heart, Lung, and Blood Institute
- Natural Sciences and Engineering Research Council of Canada
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- The paper
- Bowling, S., Sritharan, D., Osorio, F. G., Nguyen, M., Cheung, P., Rodriguez-Fraticelli, A., Patel, S., Yuan, W.-C., Fujiwara, Y., Li, B. E., Orkin, S. H., Hormoz, S., & Camargo, F. D. (2020). An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells. Cell. https://doi.org/10.1016/j.cell.2020.04.048