The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
Open accessAbstract
Pauci-immune focal necrotizing glomerulonephritis (FNGN) is a severe inflammatory disease associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA). Here we characterize autoantibodies to lysosomal membrane protein-2 (LAMP-2) and show that they are a new ANCA subtype present in almost all individuals with FNGN. Consequently, its prevalence is nearly twice that of the classical ANCAs that recognize myeloperoxidase or proteinase-3. Furthermore, antibodies to LAMP-2 cause pauci-immune FNGN when injected into rats, and a monoclonal antibody to human LAMP-2 (H4B4) induces apoptosis of human microvascular endothelium in vitro. The autoantibodies in individuals with pauci-immune FNGN commonly recognize a human LAMP-2 epitope (designated P41–49) with 100% homology to the bacterial adhesin FimH, with which they cross-react. Rats immunized with FimH develop pauci-immune FNGN and also develop antibodies to rat and human LAMP-2. Finally, we show that infections with fimbriated pathogens are common before the onset of FNGN. Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN.
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Cites
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Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?
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Type 1 pilus-mediated bacterial invasion of bladder epithelial cells
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Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
Suurmond, J., & Diamond, B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78084 · Cited by 337
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Hov, J., & Karlsen, T. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1608801 · Cited by 65
Metadata
- Authors
- Kain, R., Exner, M., Brandes, R., Ziebermayr, R., Cunningham, D., Alderson, C. A., Davidovits, A., Raab, I., Jahn, R., Ashour, O., Spitzauer, S., Sunder-Plassmann, G., Fukuda, M., Klemm, P., Rees, A. J., & Kerjaschki, D.
- Venue
- Nature Medicine
- Published
- 2008-10
- Volume
- 14
- Issue
- 10
- Pages
- 1088-1096
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2167369293
- Cited by
- 455
- References
- 41
- FWCI
- 34.22
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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