The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
Open accessAbstract
Pauci-immune focal necrotizing glomerulonephritis (FNGN) is a severe inflammatory disease associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA). Here we characterize autoantibodies to lysosomal membrane protein-2 (LAMP-2) and show that they are a new ANCA subtype present in almost all individuals with FNGN. Consequently, its prevalence is nearly twice that of the classical ANCAs that recognize myeloperoxidase or proteinase-3. Furthermore, antibodies to LAMP-2 cause pauci-immune FNGN when injected into rats, and a monoclonal antibody to human LAMP-2 (H4B4) induces apoptosis of human microvascular endothelium in vitro. The autoantibodies in individuals with pauci-immune FNGN commonly recognize a human LAMP-2 epitope (designated P41–49) with 100% homology to the bacterial adhesin FimH, with which they cross-react. Rats immunized with FimH develop pauci-immune FNGN and also develop antibodies to rat and human LAMP-2. Finally, we show that infections with fimbriated pathogens are common before the onset of FNGN. Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN.
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Cites
Nomenclature of Systemic Vasculitides
Jennette, J. C., Falk, R. J., Andrassy, K., Bacon, P. A., Churg, J., Gross, W. L., Hagen, E. C., Hoffman, G. S., Hunder, G. G., Kallenberg, C. G. M., et al. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370206 · Cited by 3,845
Self-citationVan Der Woude, F. J., Lobatto, S., Permin, H., Van Der Giessen, M., Rasmussen, N., Wiik, A., Van Es, L. A., Van Der Hem, G. K., & The, T. H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91147-x · Cited by 1,885
Jennette, J. C., & Falk, R. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711203372106 · Cited by 1,323
Falk, R. J., Terrell, R. S., Charles, L. A., & Jennette, J. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4115 · Cited by 1,261
Xiao, H., Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R. J., & Jennette, J. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15918 · Cited by 1,005
Xiao, H., Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R. J., & Jennette, J. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215918 · Cited by 919
Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?
Davies, D. J., Moran, J. E., Niall, J. F., & Ryan, G. B. (1982) · BMJ · doi:10.1136/bmj.285.6342.606 · Cited by 864
Haslett, C., Guthrie, L. A., Kopaniak, M. M., Johnston, R. B., & Henson, P. M. (1985) · PubMed Central · Cited by 779
Stegeman, C. A., Cohen Tervaert, J. W., de Jong, P. E., & Kallenberg, C. G. M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350103 · Cited by 777
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells
Martinez, J. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2803 · Cited by 758
Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract.
Connell, I., Agace, W., Klemm, P., Schembri, M., Mărild, S., & Svanborg, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9827 · Cited by 735
Self-citationAutophagy promotes MHC class II presentation of peptides from intracellular source proteins
Dengjel, J., Schoor, O., Fischer, R., Reich, M., Kraus, M., Müller, M., Kreymborg, K., Altenberend, F., Brandenburg, J., Kalbacher, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501190102 · Cited by 658
Schmid, D., Pypaert, M., & Münz, C. (2007) · Immunity · doi:10.1016/j.immuni.2006.10.018 · Cited by 577
Prevention of Mucosal Escherichia coli Infection by FimH-Adhesin-Based Systemic Vaccination
Langermann, S., Palaszynski, S., Barnhart, M., Auguste, G., Pinkner, J. S., Burlein, J., Barren, P., Koenig, S., Leath, S., Jones, C. H., et al. (1997) · Science · doi:10.1126/science.276.5312.607 · Cited by 577
Dice, J. F. (2007) · Autophagy · doi:10.4161/auto.4144 · Cited by 569
Consequences of the selective blockage of chaperone-mediated autophagy
Massey, A. C., Kaushik, S., Sovak, G., Kiffin, R., & Cuervo, A. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507436103 · Cited by 529
Kriehuber, E., Breiteneder-Geleff, S., Groeger, M., Soleiman, A., Schoppmann, S. F., Stingl, G., Kerjaschki, D., & Maurer, D. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.797 · Cited by 525
Self-citationThe apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
González-Polo, R.-A., Boya, P., Pauleau, A.-L., Jalil, A., Larochette, N., Souquère, S., Eskelinen, E.-L., Pierron, G., Saftig, P., & Kroemer, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02447 · Cited by 524
Yuki, N., Susuki, K., Koga, M., Nishimoto, Y., Odaka, M., Hirata, K., Taguchi, K., Miyatake, T., Furukawa, K., Kobata, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402391101 · Cited by 498
Mechanisms for the induction of autoimmunity by infectious agents
Wucherpfennig, K. W. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14235 · Cited by 435
Pendergraft, W. F., Preston, G. A., Shah, R. R., Tropsha, A., Carter, C. W., Jennette, J. C., & Falk, R. J. (2004) · Nature Medicine · doi:10.1038/nm968 · Cited by 379
Carlsson, S. R., Roth, J., Piller, F., & Fukuda, M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37369-1 · Cited by 345
Self-citationLangermann, S., Möllby, R., Burlein, J. E., Palaszynski, S. R., Auguste, C. G., DeFusco, A., Strouse, R., Schenerman, M. A., Hultgren, S. J., Pinkner, J. S., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315258 · Cited by 336
Lamp-2a Facilitates MHC Class II Presentation of Cytoplasmic Antigens
Zhou, D., Li, P., Lin, Y., Lott, J. M., Hislop, A. D., Canaday, D. H., Brutkiewicz, R. R., & Blum, J. S. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.009 · Cited by 309
Little, M. A., Smyth, C. L., Yadav, R., Ambrose, L., Cook, H. T., Nourshargh, S., & Pusey, C. D. (2005) · Blood · doi:10.1182/blood-2005-03-0921 · Cited by 276
Autoimmunity due to molecular mimicry as a cause of neurological disease
Levin, M. C., Lee, S. M., Kalume, F., Morcos, Y., Dohan, F. C., Hasty, K. A., Callaway, J. C., Zunt, J., Desiderio, D. M., & Stuart, J. M. (2002) · Nature Medicine · doi:10.1038/nm0502-509 · Cited by 264
The University of North Carolina at Chapel Hill University Libraries (2020) · PubMed Central · doi:10.17615/1zhf-nn29 · Cited by 240
Horvat, R., Hovorka, A., Dekan, G., Poczewski, H., & Kerjaschki, D. (1986) · The Journal of cell biology · doi:10.1083/jcb.102.2.484 · Cited by 211
Self-citationSavige, J., Dimech, W., Fritzler, M., Goeken, J., Hagen, E. C., Jennette, J. C., McEvoy, R., Pusey, C., Pollock, W., Trevisin, M., et al. (2003) · American Journal of Clinical Pathology · doi:10.1309/waepadw0k4lpuhfn · Cited by 164
Savige, F., Dimech, F., Fritzler, M., Goeken, M., Hagen, M., Jennette, M., McEvoy, P., Pusey, M., Pollock, W., Trevisin, M., et al. (2003) · American Journal of Clinical Pathology · doi:10.1309/waep-adw0-k4lp-uhfn · Cited by 160
Kozarsky, K., Kingsley, D., & Krieger, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4335 · Cited by 159
Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.
Granger, B. L., Green, S. A., Gabel, C. A., Howe, C. L., Mellman, I., & Helenius, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38504-7 · Cited by 157
Kain, R., Matsui, K., Exner, M., Binder, S., Schäffner, G., Sommer, E. M., & Kerjaschki, D. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.585 · Cited by 151
Self-citationSawada, R., Lowe, J. B., & Fukuda, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31441-8 · Cited by 130
Self-citationUnifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP‐2
Eskelinen, E., Cuervo, A. M., Taylor, M. R. G., Nishino, I., Blum, J. S., Dice, J. F., Sandoval, I. V., Lippincott‐Schwartz, J., August, J. T., & Säftig, P. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00337.x · Cited by 129
Anti-Neutrophil Cytoplasm-Associated Glomerulonephritis
Morgan, M. D., Harper, L., Williams, J. H., & Savage, C. O. S. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005080882 · Cited by 112
Gough, N. R., & Fambrough, D. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.5.1161 · Cited by 91
The elusive case for a role of mimicry in autoimmune diseases
Fourneau, J. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.11.011 · Cited by 53
Schlick, W. (1988) · PubMed · Cited by 45
Kain, R., Angata, K., Kerjaschki, D., & Fukuda, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.981 · Cited by 33
Self-citationKerjaschki, D., Ullrich, R., Exner, M., Orlando, R. A., & Farquhar, M. G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.5.2007 · Cited by 30
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Suurmond, J., & Diamond, B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78084 · Cited by 337
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Hov, J., & Karlsen, T. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1608801 · Cited by 65
Metadata
- Authors
- Kain, R., Exner, M., Brandes, R., Ziebermayr, R., Cunningham, D., Alderson, C. A., Davidovits, A., Raab, I., Jahn, R., Ashour, O., Spitzauer, S., Sunder-Plassmann, G., Fukuda, M., Klemm, P., Rees, A. J., & Kerjaschki, D.
- Venue
- Nature Medicine
- Published
- 2008-10
- Volume
- 14
- Issue
- 10
- Pages
- 1088-1096
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2167369293
- Cited by
- 455
- References
- 41
- FWCI
- 34.22
- Type
- journal article
- Language
- en
- Open access
- green
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