The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
Open accessAbstract
In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular antigens due to excessive cell death or to ineffective clearance of apoptotic debris, modification of self-antigens during inflammatory responses, and molecular mimicry contribute to the initiation of autoantibody production. We hypothesize that those autoreactive B cells that survive and produce pathogenic autoantibodies have specificity for self-antigens that are TLR ligands. Such B cells experience both B cell receptor (BCR) activation and TLR engagement, leading to an escape from tolerance. Moreover, the autoantibodies they produce form immune complexes that can activate myeloid cells and thereby establish the proinflammatory milieu that further negates tolerance mechanisms of both B and T cells.
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1 retracted
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Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus
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Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
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Jones, A. G., McDonald, T. J., Shields, B. M., Hagopian, W., & Hattersley, A. T. (2021) · Diabetes Care · doi:10.2337/dc20-2834 · Cited by 122
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Immunological memory in rheumatic inflammation - a roadblock to tolerance induction
Maschmeyer, P., Chang, H.-D., Cheng, Q., Mashreghi, M.-F., Hiepe, F., Alexander, T., & Radbruch, A. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00601-6 · Cited by 40
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress
Gjølberg, T. T., Mester, S., Calamera, G., Telstad, J. S., Sandlie, I., & Andersen, J. T. (2025) · BioDrugs · doi:10.1007/s40259-025-00708-2 · Cited by 20
Metadata
- Authors
- Suurmond, J., & Diamond, B.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-05-04
- Volume
- 125
- Issue
- 6
- Pages
- 2194-2202
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2021990477
- Cited by
- 337
- References
- 109
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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