The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes
Open accessAbstract
Imaging agents that enable direct visualization and quantification of apoptosis in vivo have great potential value for monitoring chemotherapeutic response as well as for early diagnosis and disease monitoring. We describe here the development of fluorescently labeled activity-based probes (ABPs) that covalently label active caspases in vivo. We used these probes to monitor apoptosis in the thymi of mice treated with dexamethasone as well as in tumor-bearing mice treated with the apoptosis-inducing monoclonal antibody Apomab (Genentech). Caspase ABPs provided direct readouts of the kinetics of apoptosis in live mice, whole organs and tissue extracts. The probes produced a maximum fluorescent signal that could be monitored noninvasively and that coincided with the peak in caspase activity, as measured by gel analysis. Overall, these studies demonstrate that caspase-specific ABPs have the potential to be used for noninvasive imaging of apoptosis in both preclinical and clinical settings.
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Vivès, E., Brodin, P., & Lebleu, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.16010 · Cited by 2,373
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17907 · Cited by 2,068
Reversible Tumorigenesis by MYC in Hematopoietic Lineages
Felsher, D. W., & Bishop, J. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80367-6 · Cited by 881
Richard, J. P., Melikov, K., Brooks, H., Prevot, P., Lebleu, B., & Chernomordik, L. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m401604200 · Cited by 604
Blum, G., von Degenfeld, G., Merchant, M. J., Blau, H. M., & Bogyo, M. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.26 · Cited by 467
Self-citationVisualisation of cell death in vivo in patients with acute myocardial infarction
Hofstra, L., Liem, I. H., Dumont, E. A., Boersma, H. H., van Heerde, W. L., Doevendans, P. A., DeMuinck, E., Wellens, H., Kemerink, G. J., Reutelingsperger, C. P., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02482-x · Cited by 436
Targeting the extrinsic apoptosis pathway in cancer
Ashkenazi, A. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.04.001 · Cited by 418
Activity-based probes that target diverse cysteine protease families
Kato, D., Boatright, K. M., Berger, A. B., Nazif, T., Blum, G., Ryan, C., Chehade, K. A. H., Salvesen, G. S., & Bogyo, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio707 · Cited by 356
Self-citationNtziachristos, V., Schellenberger, E. A., Ripoll, J., Yessayan, D., Graves, E., Bogdanov, A., Josephson, L., & Weissleder, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401137101 · Cited by 348
Belhocine, T., Steinmetz, N. D., Hustinx, R., Bartsch, P., Jérusalem, G., Seidel, L., Rigo, P., & Green, A. M. (2002) · PubMed · Cited by 289
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Metadata
- Authors
- Edgington, L. E., Berger, A. B., Blum, G., Albrow, V. E., Paulick, M. G., Lineberry, N., & Bogyo, M.
- Venue
- Nature Medicine
- Published
- 2009-07-13
- Volume
- 15
- Issue
- 8
- Pages
- 967-973
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1999891600
- Cited by
- 276
- References
- 27
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
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