Cited by 749Nanoparticle-Based Drug DeliveryBarrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Transport of drugs from blood vessels to tumour tissue

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Dewhirst, Mark W., Secomb, Timothy W.·2017·Nature Reviews Cancer

Abstract

The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function of the tumour vasculature and the transport properties of the drug as it moves through microvessel walls and in the extravascular tissue. The aim of this Review is to provide a broad, balanced perspective on the current understanding of drug transport to tumour cells and on the progress in developing methods to enhance drug delivery. First, the fundamental processes of solute transport in blood and tissue by convection and diffusion are reviewed, including the dependence of penetration distance from vessels into tissue on solute binding or uptake in tissue. The effects of the abnormal characteristics of tumour vasculature and extravascular tissue on these transport properties are then discussed. Finally, methods for overcoming limitations in drug transport and thereby achieving improved therapeutic results are surveyed.

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Crossref · 10.1038/nrc.2017.93

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  • Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.

    “Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.”

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Authors
Dewhirst, M. W., & Secomb, T. W.
Affiliations
  • Duke Medical Center (US)
  • University of Arizona (US)
Corresponding author
Dewhirst, Mark W.
Venue
Nature Reviews Cancer
Published
2017-12
Volume
17
Issue
12
Pages
738-750
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2767780867
Cited by
749
References
188
Citations by year
2026: 63 · 2025: 98 · 2024: 91 · 2023: 87 · 2022: 108 · 2021: 97 · 2020: 104 · 2019: 62 · 2018: 38 · 2017: 1
FWCI
4.06
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL034555)
  • National Cancer Institute (R01CA040355)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
tumor vasculature, drug transport, solute transport, convection and diffusion, penetration depth, plasma pharmacokinetics, tumor microenvironment, tissue absorption
MeSH terms
Antineoplastic Agents, Biological Transport, Blood Vessels, Humans, Neoplasms, Drug Delivery Systems

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