The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032691 · Cited by 10,968
Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
Motzer, R. J., Hutson, T. E., Tomczak, P., Michaelson, M. D., Bukowski, R. M., Rixe, O., Oudard, S., Negrier, S., Szczylik, C., Kim, S. T., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065044 · Cited by 5,775
Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer
Sandler, A., Gray, R., Perry, M. C., Brahmer, J., Schiller, J. H., Dowlati, A., Lilenbaum, R., & Johnson, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061884 · Cited by 5,761
Vascular endothelial growth factor (VEGF) and its receptors
NEUFELD, G., COHEN, T., GENGRINOVITCH, S., & POLTORAK, Z. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.9 · Cited by 3,483
VEGF receptor signalling ? in control of vascular function
Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer
Miller, K., Wang, M., Gralow, J., Dickler, M., Cobleigh, M., Perez, E. A., Shenkier, T., Cella, D., & Davidson, N. E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072113 · Cited by 3,081
Requirement of Vascular Integrin α v β 3 for Angiogenesis
Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
Ferrara, N., Hillan, K. J., Gerber, H.-P., & Novotny, W. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1381 · Cited by 2,625
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
VEGF-targeted therapy: mechanisms of anti-tumour activity
Ellis, L. M., & Hicklin, D. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2403 · Cited by 1,673
Clinical translation of angiogenesis inhibitors
Kerbel, R., & Folkman, J. (2002) · Nature Reviews Cancer · doi:10.1038/nrc905 · Cited by 1,517
N -Methylated Cyclic RGD Peptides as Highly Active and Selective α V β 3 Integrin Antagonists
Dechantsreiter, M. A., Planker, E., Mathä, B., Lohof, E., Hölzemann, G., Jonczyk, A., Goodman, S. L., & Kessler, H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm970832g · Cited by 838
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.
Brooks, P. C., Strömblad, S., Klemke, R., Visscher, D., Sarkar, F. H., & Cheresh, D. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118227 · Cited by 828
Prewett, M. C., Huber, J., Li, Y., Santiago, A., O'Connor, W., King, K. D., Overholser, J. C., Hooper, A. T., Pytowski, B., Witte, L., et al. (1999) · PubMed · Cited by 659
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins
Reynolds, L. E., Wyder, L., Lively, J. C., Taverna, D., Robinson, S. D., Huang, X., Sheppard, D., Hynes, R. O., & Hodivala-Dilke, K. M. (2002) · Nature Medicine · doi:10.1038/nm0102-27 · Cited by 613
Self-citationHaubner, R., Wester, H. J., Weber, W., Mang, C., Ziegler, S. I., Goodman, S. L., Senekowitsch–Schmidtke, R., Kessler, H., & Schwaiger, M. (2001) · PubMed · Cited by 563
A reevaluation of integrins as regulators of angiogenesis
Hynes, R. O. (2002) · Nature Medicine · doi:10.1038/nm0902-918 · Cited by 548
Lampugnani, M. G., Orsenigo, F., Gagliani, M. C., Tacchetti, C., & Dejana, E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602080 · Cited by 525
Varner, J. A., & Cheresh, D. A. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80115-3 · Cited by 522
Caswell, P. T., Chan, M., Lindsay, A. J., McCaffrey, M. W., Boettiger, D., & Norman, J. C. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804140 · Cited by 388
Self-citationRoberts, M., Barry, S., Woods, A., van der Sluijs, P., & Norman, J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00442-0 · Cited by 348
Self-citationIn vivo Near-Infrared Fluorescence Imaging of Integrin αvβ3 in Brain Tumor Xenografts
Chen, X., Conti, P. S., & Moats, R. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1956 · Cited by 347
Danen, E. H. J., Sonneveld, P., Brakebusch, C., Fässler, R., & Sonnenberg, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205014 · Cited by 333
Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma
Nabors, L. B., Mikkelsen, T., Rosenfeld, S. S., Hochberg, F., Akella, N. S., Fisher, J. D., Cloud, G. A., Zhang, Y., Carson, K., Wittemer, S. M., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.6514 · Cited by 290
Endocytic transport of integrins during cell migration and invasion
Caswell, P., & Norman, J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.03.004 · Cited by 256
Self-citationMacDonald, T. J., Taga, T., Shimada, H., Tabrizi, P., Zlokovic, B. V., Cheresh, D. A., & Laug, W. E. (2001) · Neurosurgery · doi:10.1097/00006123-200101000-00026 · Cited by 240
Eskens, F. A. L. M., Dumez, H., Hoekstra, R., Perschl, A., Brindley, C., Böttcher, S., Wynendaele, W., Drevs, J., Verweij, J., & van Oosterom, A. T. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00057-1 · Cited by 225
Regulators of Endocytosis Maintain Localized Receptor Tyrosine Kinase Signaling in Guided Migration
Jékely, G., Sung, H.-H., Luque, C. M., & Rørth, P. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.06.004 · Cited by 224
Calabrese, E. J. (2005) · Critical Reviews in Toxicology · doi:10.1080/10408440591034502 · Cited by 213
αvβ3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro
Nisato, R. E., Tille, J.-C., Jonczyk, A., Goodman, S. L., & Pepper, M. S. (2003) · Angiogenesis · doi:10.1023/b:agen.0000011801.98187.f2 · Cited by 207
Integrin signaling is critical for pathological angiogenesis
Mahabeleshwar, G. H., Feng, W., Phillips, D. R., & Byzova, T. V. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060807 · Cited by 206
Integrins: Molecular targets in cancer therapy
Tucker, G. C. (2006) · Current Oncology Reports · doi:10.1007/s11912-006-0043-3 · Cited by 203
Self-citationTaga, T., Suzuki, A., Gonzalez‐Gomez, I., Gilles, F. H., Stins, M., Shimada, H., Barsky, L., Weinberg, K. I., & Laug, W. E. (2002) · International Journal of Cancer · doi:10.1002/ijc.10265 · Cited by 198
Ewan, L. C., Jopling, H. M., Jia, H., Mittar, S., Bagherzadeh, A., Howell, G. J., Walker, J. H., Zachary, I. C., & Ponnambalam, S. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00462.x · Cited by 183
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment
Gampel, A., Moss, L., Jones, M. C., Brunton, V., Norman, J. C., & Mellor, H. (2006) · Blood · doi:10.1182/blood-2005-12-007484 · Cited by 181
Self-citationIn vivo therapy of malignant melanoma by means of antagonists of alphav integrins.
Mitjans, F., Meyer, T., Fittschen, C., Goodman, S. L., Jonczyk, A., Marshall, J. F., Reyes, G., & Piulats, J. (2000) · PubMed · Cited by 171
Moving Membrane up to the Front of Migrating Cells
Bretscher, M. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81246-5 · Cited by 164
Integrins in angiogenesis: multitalented molecules in a balancing act
Hodivala‐Dilke, K., Reynolds, A. R., & Reynolds, L. E. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0774-5 · Cited by 161
Self-citationReynolds, A. R., Reynolds, L. E., Nagel, T., Lively, J. C., Robinson, S. D., Hicklin, D. J., Bodary, S. C., & Hodivala‐Dilke, K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2760 · Cited by 157
Self-citationαvβ3 integrin and angiogenesis: a moody integrin in a changing environment
Hodivala‐Dilke, K. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.06.007 · Cited by 154
Self-citationFan, G.-H., Lapierre, L. A., Goldenring, J. R., Sai, J., & Richmond, A. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0706 · Cited by 145
Duval, M., Bédard-Goulet, S., Delisle, C., & Gratton, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301410200 · Cited by 132
Hariharan, S., Gustafson, D. L., Holden, S. N., McConkey, D. J., Davis, D. W., Morrow, M., Basche, M., Gore, L., Zang, C., O’Bryant, C. L., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm140 · Cited by 130
Buerkle, M. A., Pahernik, S. A., Sutter, A., Jonczyk, A., Messmer, K., & Dellian, M. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600141 · Cited by 130
Frieß, H., Langrehr, J. M., Oettle, H., Raedle, J., Niedergethmann, M., Dittrich, C., HOSSFELD, D. K., Stöger, H., Neyns, B., Herzog, P., et al. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-285 · Cited by 127
Integrin Inhibitors Reaching the Clinic
Stupp, R., & Rüegg, C. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.8376 · Cited by 122
Superactivation of integrin αvβ3 by low antagonist concentrations
Legler, D. F., Wiedle, G., Ross, F. P., & Imhof, B. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1545 · Cited by 112
Alpha v integrin inhibitors and cancer therapy.
Tucker, G. C. (2003) · PubMed · Cited by 108
Self-citationMaubant, S., Saint-Dizier, D., Boutillon, M., Perron‐Sierra, F., Casara, P., Hickman, J. A., Tucker, G. C., & Obberghen‐Schilling, E. V. (2006) · Blood · doi:10.1182/blood-2006-05-023580 · Cited by 98
Self-citationEpidermal Growth Factor Receptor Distribution during Chemotactic Responses
Bailly, M., Wyckoff, J. B., Bouzahzah, B., Hammerman, R., Sylvestre, V. T., Cammer, M., Pestell, R. G., & Segall, J. E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.11.3873 · Cited by 86
Human Malignant Glioma Therapy Using Anti-αVβ3 Integrin Agents
Chatterjee, S., Matsumura, A., Schradermeier, J., & Gillespie, G. Y. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006444300504 · Cited by 81
Dormond, O., Ponsonnet, L., Hasmim, M., Foletti, A., & Rüegg, C. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-11-0728 · Cited by 55
Cited by
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Stupp, R., Hegi, M. E., Gorlia, T., Erridge, S. C., Perry, J., Hong, Y.-K., Aldape, K. D., Lhermitte, B., Pietsch, T., Grujicic, D., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70379-1 · Cited by 1,052
Antiangiogenic therapy: impact on invasion, disease progression, and metastasis
Ebos, J. M. L., & Kerbel, R. S. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.21 · Cited by 685
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
Jun, J.-I., & Lau, L. F. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3599 · Cited by 568
Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
Felcht, M., Luck, R., Schering, A., Seidel, P., Srivastava, K., Hu, J., Bartol, A., Kienast, Y., Vettel, C., Loos, E. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58832 · Cited by 479
Metadata
- Authors
- Reynolds, A. R., Hart, I. R., Watson, A. R., Welti, J. C., Silva, R. G., Robinson, S. D., Da Violante, G., Gourlaouen, M., Salih, M., Jones, M. C., Jones, D. T., Saunders, G., Kostourou, V., Perron-Sierra, F., Norman, J. C., Tucker, G. C., & Hodivala-Dilke, K. M.
- Venue
- Nature Medicine
- Published
- 2009-03-22
- Volume
- 15
- Issue
- 4
- Pages
- 392-400
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2167107456
- Cited by
- 490
- References
- 52
- FWCI
- 34.01
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.