The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment
Abstract
Endothelial cells respond to vascular endothelial growth factor (VEGF) to produce new blood vessels. This process of angiogenesis makes a critical contribution during embryogenesis and also in the response to ischemia in adult tissues. We have studied the intracellular trafficking of the major VEGF receptor KDR (VEGFR2). Unlike other related growth factor receptors, we find that a significant proportion of KDR is held in an endosomal storage pool within endothelial cells. We find that KDR can be delivered to the plasma membrane from this intracellular pool and that VEGF stimulates this recycling to the cell surface. KDR recycling appears to be distinct from the previously characterized Rab4- and Rab11-dependent pathways, but, instead, KDR+ recycling vesicles contain Src tyrosine kinase and VEGF-stimulated recycling requires Src activation. Taken together, these data show that intracellular trafficking of KDR is markedly different from other receptor tyrosine kinases and suggest that the regulation of KDR trafficking by VEGF provides a novel mechanism for controlling the sensitivity of endothelial cells to proangiogenic signals.
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Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520
Cited by
Signal transduction by vascular endothelial growth factor receptors
Koch, S., Tugues, S., Li, X., Gualandi, L., & Claesson-Welsh, L. (2011) · Biochemical Journal · doi:10.1042/bj20110301 · Cited by 1,635
Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498
Reynolds, A. R., Hart, I. R., Watson, A. R., Welti, J. C., Silva, R. G., Robinson, S. D., Da Violante, G., Gourlaouen, M., Salih, M., Jones, M. C., et al. (2009) · Nature Medicine · doi:10.1038/nm.1941 · Cited by 490
Self-citationVEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
Scaldaferri, F., Vetrano, S., Sans, M., Arena, V., Straface, G., Stigliano, E., Repici, A., Sturm, A., Malesci, A., Panes, J., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.09.064 · Cited by 340
Goueli, B. S., Powell, M. B., Finger, E. C., & Pfeffer, S. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204540109 · Cited by 41
Metadata
- Authors
- Gampel, A., Moss, L., Jones, M. C., Brunton, V., Norman, J. C., & Mellor, H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-10-15
- Volume
- 108
- Issue
- 8
- Pages
- 2624-2631
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2125801586
- Cited by
- 181
- References
- 3
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gampel, A., Moss, L., Jones, M. C., Brunton, V., Norman, J. C., & Mellor, H. (2006). VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood. https://doi.org/10.1182/blood-2005-12-007484
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