The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Inhibition of osteoblastic bone formation by nuclear factor-κB
Open accessAbstract
An imbalance in bone formation relative to bone resorption results in the net bone loss that occurs in osteoporosis and inflammatory bone diseases. Although it is well known how bone resorption is stimulated, the molecular mechanisms that mediate impaired bone formation are poorly understood. Here we show that the time- and stage-specific inhibition of endogenous inhibitor of κB kinase (IKK)–nuclear factor-κB (NF-κB) in differentiated osteoblasts substantially increases trabecular bone mass and bone mineral density without affecting osteoclast activities in young mice. Moreover, inhibition of IKK–NF-κB in differentiated osteoblasts maintains bone formation, thereby preventing osteoporotic bone loss induced by ovariectomy in adult mice. Inhibition of IKK–NF-κB enhances the expression of Fos-related antigen-1 (Fra-1), an essential transcription factor involved in bone matrix formation in vitro and in vivo. Taken together, our results suggest that targeting IKK–NF-κB may help to promote bone formation in the treatment of osteoporosis and other bone diseases.
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Cites
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
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Self-citationPathogenesis of osteoporosis: concepts, conflicts, and prospects
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Genetic regulation of osteoclast development and function
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Self-citationNF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia
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Cited by
Khosla, S., Oursler, M. J., & Monroe, D. G. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.03.008 · Cited by 943
Inflammatory bone loss: pathogenesis and therapeutic intervention
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Promoting tissue regeneration by modulating the immune system
Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
Herranz, D., Muñoz-Martin, M., Cañamero, M., Mulero, F., Martinez-Pastor, B., Fernandez-Capetillo, O., & Serrano, M. (2010) · Nature Communications · doi:10.1038/ncomms1001 · Cited by 612
Metadata
- Authors
- Chang, J., Wang, Z., Tang, E., Fan, Z., McCauley, L., Franceschi, R., Guan, K., Krebsbach, P. H., & Wang, C.-Y.
- Venue
- Nature Medicine
- Published
- 2009-05-17
- Volume
- 15
- Issue
- 6
- Pages
- 682-689
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1967937835
- Cited by
- 481
- References
- 39
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Chang, J., Wang, Z., Tang, E., Fan, Z., McCauley, L., Franceschi, R., Guan, K., Krebsbach, P. H., & Wang, C.-Y. (2009). Inhibition of osteoblastic bone formation by nuclear factor-κB. Nature Medicine. https://doi.org/10.1038/nm.1954
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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