A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

Nesbitt, Warwick S, Westein, Erik, Tovar-Lopez, Francisco Javier, Tolouei, Elham, Mitchell, Arnan, Fu, Jia, Carberry, Josie, Fouras, Andreas, Jackson, Shaun P·2009·Nature Medicine

DOI 10.1038/nm.1955

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nm.1955

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554
Dielectrophoresis for manipulation of micro/nano particles in microfluidic systems
Zhang, C., Khoshmanesh, K., Mitchell, A., & Kalantar-zadeh, K. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2922-6 · Cited by 305
Self-citation
In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
Tsai, M., Kita, A., Leach, J., Rounsevell, R., Huang, J. N., Moake, J., Ware, R. E., Fletcher, D. A., & Lam, W. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58753 · Cited by 297
Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model
Kim, S., Chung, M., Ahn, J., Lee, S., & Jeon, N. L. (2016) · Lab on a Chip · doi:10.1039/c6lc00910g · Cited by 227
Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., van den Berg, A., Malda, J., & van der Meer, A. D. (2017) · Lab on a Chip · doi:10.1039/c7lc00202e · Cited by 226
A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function
Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., & Ingber, D. E. (2016) · Nature Communications · doi:10.1038/ncomms10176 · Cited by 182
Measurement of whole blood thrombus formation using parallel-plate flow chambers–a practical guide
Van Kruchten, R., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2012) · Platelets · doi:10.3109/09537104.2011.630848 · Cited by 153
Flow-induced stress on adherent cells in microfluidic devices
Shemesh, J., Jalilian, I., Shi, A., Heng Yeoh, G., Knothe Tate, M. L., & Ebrahimi Warkiani, M. (2015) · Lab on a Chip · doi:10.1039/c5lc00633c · Cited by 144
Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions
Mannino, R. G., Myers, D. R., Ahn, B., Wang, Y., Rollins, M., Gole, H., Lin, A. S., Guldberg, R. E., Giddens, D. P., Timmins, L. H., et al. (2015) · Scientific Reports · doi:10.1038/srep12401 · Cited by 127
Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear
Chen, Z., Lu, J., Zhang, C., Hsia, I., Yu, X., Marecki, L., Marecki, E., Asmani, M., Jain, S., Neelamegham, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10067-6 · Cited by 64
Thrombosis-on-a-chip: prospective impact of microphysiological models of vascular thrombosis
Pandian, N. K. R., Mannino, R. G., Lam, W. A., & Jain, A. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2017.12.001 · Cited by 56
Monitoring in vitro thrombus formation with novel microfluidic devices
Westein, E., de Witt, S., Lamers, M., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2012) · Platelets · doi:10.3109/09537104.2012.709653 · Cited by 54

Authors: Nesbitt, W. S., Westein, E., Tovar-Lopez, F. J., Tolouei, E., Mitchell, A., Fu, J., Carberry, J., Fouras, A., & Jackson, S. P.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2009-05-24
Volume: 15
Issue: 6
Pages: 665-673
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/nm.1955
OpenAlex: W2007206486
Cited by: 862
References: 0
FWCI: 29.52
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review