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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

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Muchamuel, Tony, Basler, Michael, Aujay, Monette A, Suzuki, Erika, Kalim, Khalid W, Lauer, Christoph, Sylvain, Catherine, Ring, Eileen R, Shields, Jamie, Jiang, Jing, Shwonek, Peter, Parlati, Francesco, Demo, Susan D, Bennett, Mark K, Kirk, Christopher J, Groettrup, Marcus·2009·Nature Medicine

DOI 10.1038/nm.1978

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“Furthermore, a number of selective inhibitors of the chymotrypsin-like subunit of the immunoproteasome have been reported, including PR957 (REF. 107) and IPSI-001 (REF. 108 ).”
Background
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Kisselev, A. F., van der Linden, W. A., & Overkleeft, H. S. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.01.003 · Cited by 527
Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance
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See all 599

Authors: Muchamuel, T., Basler, M., Aujay, M. A., Suzuki, E., Kalim, K. W., Lauer, C., Sylvain, C., Ring, E. R., Shields, J., Jiang, J., Shwonek, P., Parlati, F., Demo, S. D., Bennett, M. K., Kirk, C. J., & Groettrup, M.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2009-06-14
Volume: 15
Issue: 7
Pages: 781-787
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/nm.1978
OpenAlex: W1974010669
Cited by: 599
References: 36
FWCI: 13.56
Type: journal article
Language: en
Open access: green

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

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