The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Matrix-insensitive protein assays push the limits of biosensors in medicine
Open accessAbstract
Advances in biosensor technologies for in vitro diagnostics have the potential to transform the practice of medicine. Despite considerable work in the biosensor field, there is still no general sensing platform that can be ubiquitously applied to detect the constellation of biomolecules in diverse clinical samples (for example, serum, urine, cell lysates or saliva) with high sensitivity and large linear dynamic range. A major limitation confounding other technologies is signal distortion that occurs in various matrices due to heterogeneity in ionic strength, pH, temperature and autofluorescence. Here we present a magnetic nanosensor technology that is matrix insensitive yet still capable of rapid, multiplex protein detection with resolution down to attomolar concentrations and extensive linear dynamic range. The matrix insensitivity of our platform to various media demonstrates that our magnetic nanosensor technology can be directly applied to a variety of settings such as molecular biology, clinical diagnostics and biodefense.
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Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Cited by
Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1641 · Cited by 2,119
Biological applications of magnetic nanoparticles
Colombo, M., Carregal-Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I. B., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,315
Ultrasensitive Magnetic Field Sensors for Biomedical Applications
Murzin, D., Mapps, D. J., Levada, K., Belyaev, V., Omelyanchik, A., Panina, L., & Rodionova, V. (2020) · Sensors · doi:10.3390/s20061569 · Cited by 277
Magnetoresistive Sensor Development Roadmap (Non-Recording Applications)
Zheng, C., Zhu, K., Cardoso de Freitas, S., Chang, J.-Y., Davies, J. E., Eames, P., Freitas, P. P., Kazakova, O., Kim, C., Leung, C.-W., et al. (2019) · IEEE Transactions on Magnetics · doi:10.1109/tmag.2019.2896036 · Cited by 268
Self-citationEarhart, C. M., Hughes, C. E., Gaster, R. S., Ooi, C. C., Wilson, R. J., Zhou, L. Y., Humke, E. W., Xu, L., Wong, D. J., Willingham, S. B., et al. (2014) · Lab Chip · doi:10.1039/c3lc50580d · Cited by 165
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Metadata
- Authors
- Gaster, R. S., Hall, D. A., Nielsen, C. H., Osterfeld, S. J., Yu, H., Mach, K. E., Wilson, R. J., Murmann, B., Liao, J. C., Gambhir, S. S., & Wang, S. X.
- Venue
- Nature Medicine
- Published
- 2009-10-11
- Volume
- 15
- Issue
- 11
- Pages
- 1327-1332
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2105123440
- Cited by
- 382
- References
- 2
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- green
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