The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Interactions between the immune and nervous systems in pain
Open accessAbstract
Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the transition from acute to chronic pain. In response to injury, resident immune cells are activated and blood-borne immune cells are recruited to the site of injury. Immune cells not only contribute to immune protection but also initiate the sensitization of peripheral nociceptors. Through the synthesis and release of inflammatory mediators and interactions with neurotransmitters and their receptors, the immune cells, glia and neurons form an integrated network that coordinates immune responses and modulates the excitability of pain pathways. The immune system also reduces sensitization by producing immune-derived analgesic and anti-inflammatory or proresolution agents. A greater understanding of the role of the immune system in pain processing and modulation reveals potential targets for analgesic drug development and new therapeutic opportunities for managing chronic pain.
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Cites
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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
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Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
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“Among the many immune- or glia-derived mediators that are related to pain hypersensitivity, IL-1β is a key cytokine that modulates microglia, astrocytes and neuron”
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Cited by
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996
Bacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639
Metadata
- Authors
- Ren, K., & Dubner, R.
- Venue
- Nature Medicine
- Published
- 2010-10-14
- Volume
- 16
- Issue
- 11
- Pages
- 1267-1276
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2127070923
- Cited by
- 814
- References
- 7
- FWCI
- 30.25
- Type
- journal article
- Language
- en
- Open access
- green
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