Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
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A growing body of evidence indicates that resolution of acute inflammation is an active process. Resolvins are a new family of lipid mediators enzymatically generated within resolution networks that possess unique and specific functions to orchestrate catabasis, the phase in which disease declines. Resolvin D2 (RvD2) was originally identified in resolving exudates, yet its individual contribution in resolution remained to be elucidated. Here, we establish RvD2's potent stereoselective actions in reducing excessive neutrophil trafficking to inflammatory loci. RvD2 decreased leukocyte-endothelial interactions in vivo by endothelial-dependent nitric oxide production, and by direct modulation of leukocyte adhesion receptor expression. In mice with microbial sepsis initiated by caecal ligation and puncture, RvD2 sharply decreased both local and systemic bacterial burden, excessive cytokine production and neutrophil recruitment, while increasing peritoneal mononuclear cells and macrophage phagocytosis. These multi-level pro-resolving actions of RvD2 translate to increased survival from sepsis induced by caecal ligation and puncture and surgery. Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance.
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SPMs suppress inflammation but, unlike anti-inflammatory drugs, promote both repair and continued pathogen clearance.
“From a translational perspective, SPMs suppress inflammation but, unlike anti-inflammatory drugs, these pro-resolving mediators promote both repair and continued pathogen clearance33,213–215.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [215]
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Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
The Pathophysiology and Treatment of Sepsis
Hotchkiss, R. S., & Karl, I. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021333 · Cited by 4,098 · see citing works
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932 · see citing works
Self-citationImmunodesign of experimental sepsis by cecal ligation and puncture
Rittirsch, D., Huber-Lang, M. S., Flierl, M. A., & Ward, P. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.214 · Cited by 2,209 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
Self-citationDombrovskiy, V. Y., Martin, A. A., Sunderram, J., & Paz, H. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000261890.41311.e9 · Cited by 1,250 · see citing works
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works
Self-citationThe discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863 · see citing works
Animal Models of sepsis: setting the stage
Buras, J. A., Holzmann, B., & Sitkovsky, M. V. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1854 · Cited by 838 · see citing works
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
Weber, C., Zernecke, A., & Libby, P. (2008) · Nature reviews. Immunology · doi:10.1038/nri2415 · Cited by 777 · see citing works
Inflammatory Resolution: new opportunities for drug discovery
Gilroy, D. W., Lawrence, T., Perretti, M., & Rossi, A. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1383 · Cited by 772 · see citing works
Self-citationPlatelet-Activating Factor and Related Lipid Mediators
Prescott, S. M., Zimmerman, G. A., Stafforini, D. M., & McIntyre, T. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.419 · Cited by 747 · see citing works
Shimizu, T. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145616 · Cited by 577 · see citing works
Huang, X., Venet, F., Wang, Y. L., Lepape, A., Yuan, Z., Chen, Y., Swan, R., Kherouf, H., Monneret, G., Chung, C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809422106 · Cited by 513 · see citing works
Osuchowski, M. F., Welch, K. B., Siddiqui, J., & Remick, D. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1967 · Cited by 511 · see citing works
Functional roles for C5a receptors in sepsis
Rittirsch, D., Flierl, M. A., Nadeau, B. A., Day, D. E., Huber-Lang, M. S., Mackay, C. R., Zetoune, F. S., Gerard, N. P., Cianflone, K., Köhl, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1753 · Cited by 386 · see citing works
Litvak, V., Ramsey, S. A., Rust, A. G., Zak, D. E., Kennedy, K. A., Lampano, A. E., Nykter, M., Shmulevich, I., & Aderem, A. (2009) · Nature Immunology · doi:10.1038/ni.1721 · Cited by 295 · see citing works
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
Shimizu, T., Rådmark, O., & Samuelsson, B. O. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.689 · Cited by 290 · see citing works
Haworth, R., Platt, N., Keshav, S., Hughes, D. A., Darley, E., Suzuki, H., Kurihara, Y., Kodama, T., & Gordon, S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1431 · Cited by 274 · see citing works
Paul‐Clark, M. J., Cao, T. V., Moradi‐Bidhendi, N., Cooper, D., & Gilroy, D. W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040566 · Cited by 236 · see citing works
Self-citationSinger, P., Shapiro, H., Theilla, M., Anbar, R., Singer, J., & Cohen, J. D. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1142-4 · Cited by 232 · see citing works
Takano, T., Clish, C. B., Gronert, K., Petasis, N. A., & Serhan, C. N. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1578 · Cited by 230 · see citing works
Self-citationAdverse functions of IL‐17A in experimental sepsis
Flierl, M. A., Rittirsch, D., Gao, H., Hoesel, L. M., Nadeau, B. A., Day, D. E., Zetoune, F. S., Sarma, J. V., Huber-Lang, M. S., Ferrara, J. L. M., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-105221 · Cited by 201 · see citing works
Bucci, M., Roviezzo, F., Posadas, I., Yu, J., Parente, L., Sessa, W. C., Ignarro, L. J., & Cirino, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408906102 · Cited by 142 · see citing works
Souza, D. G., Fagundes, C. T., Amaral, F. A., Cisalpino, D., Sousa, L. P., Vieira, A. T., Pinho, V., Nicoli, J. R., Vieira, L. Q., Fierro, I. M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8533 · Cited by 138 · see citing works
Chatterjee, B. E., Yona, S., Rosignoli, G., Young, R. E., Nourshargh, S., Flower, R. J., & Perretti, M. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405206 · Cited by 121 · see citing works
Self-citationNovel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow
Cooper, D., Norling, L. V., & Perretti, M. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1207831 · Cited by 114 · see citing works
Self-citationIntravenous fish oil blunts the physiological response to endotoxin in healthy subjects.
Pluess, T.-T., Hayoz, D., Berger, M. M., Tappy, L., Revelly, J.-P., Michaeli, B., Carpentier, Y. A., & Chioléro, R. L. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0591-5 · Cited by 94 · see citing works
First total synthesis of 7(S),16(R),17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator
Rodrı́guez, A. R., & Spur, B. W. (2004) · Tetrahedron Letters · doi:10.1016/j.tetlet.2004.09.129 · Cited by 62 · see citing works
Mediator Lipidomics: Search Algorithms for Eicosanoids, Resolvins, and Protectins
Serhan, C. N., Lu, Y., Hong, S., & Yang, R. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)32012-0 · Cited by 48 · see citing works
Self-citationFarolan, L. R., Gotō, M., Myers, T. F., Anderson, C. L., & Zeller, W. P. (1996) · Shock · doi:10.1097/00024382-199610000-00007 · Cited by 9 · see citing works
First Total Synthesis of 7(S),16(R),17(S)‐Resolvin D2, a Potent Antiinflammatory Lipid Mediator.
Rodrı́guez, A. R., & Spur, B. W. (2005) · ChemInform · doi:10.1002/chin.200508224 · Cited by 8 · see citing works
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Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Self-citationNeutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,044 · see citing works
Kinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.38 · Cited by 2,724 · see citing works
Neutrophil Function: From Mechanisms to Disease
Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D., & Zychlinsky, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074942 · Cited by 1,695 · see citing works
Neutrophils, from marrow to microbes.
Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,550 · see citing works
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344 · see citing works
Self-citationInflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works
Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities
Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093 · see citing works
Phagocyte partnership during the onset and resolution of inflammation
Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works
Sepsis: a roadmap for future research
Cohen, J., Vincent, J., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S. G., Delaloye, J., Opal, S. M., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 996 · see citing works
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works
Self-citationAdvances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 869 · see citing works
Interactions between the immune and nervous systems in pain
Ren, K., & Dubner, R. A. (2010) · Nature Medicine · doi:10.1038/nm.2234 · Cited by 817 · see citing works
Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 811 · see citing works
Self-citationAdvances in Our Understanding of Oxylipins Derived from Dietary PUFAs.
Gabbs, M., Leng, S., Devassy, J., Monirujjaman, M., & Aukema, H. (2015) · Advances in Nutrition · doi:10.3945/an.114.007732 · Cited by 734 · see citing works
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation
Basil, M. C., & Levy, B. D. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.4 · Cited by 805 · see citing works
Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.015 · Cited by 784 · see citing works
The neutrophil in vascular inflammation
Phillipson, M., & Kubes, P. (2011) · Nature Medicine · doi:10.1038/nm.2514 · Cited by 774 · see citing works
The role of the microbiota in periodontal disease
Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020) · Periodontology 2000 · doi:10.1111/prd.12296 · Cited by 698 · see citing works
Infection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works
Self-citationThe resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583 · see citing works
Self-citationThe resolution of inflammation
Buckley, C. D., Gilroy, D. W., Serhan, C. N., Stockinger, B., & Tak, P. P. (2012) · Nature reviews. Immunology · doi:10.1038/nri3362 · Cited by 580 · see citing works
Self-citationLipid Mediators in the Resolution of InflammationPreprint
Serhan, C. N., Chiang, N., Dalli, J., & Levy, B. D. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016311 · Cited by 545 · see citing works
Self-citationInflammation and its Resolution as Determinants of Acute Coronary Syndromes
Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 523 · see citing works
Macrophages and the maintenance of homeostasis
Mosser, D. M., Hamidzadeh, K., & Gonçalves, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00541-3 · Cited by 509 · see citing works
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Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 513 · see citing works
Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492 · see citing works
Self-citationSpecialized pro-resolving lipid mediators in the inflammatory response: An update
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Self-citationThe Nexus Between Periodontal Inflammation and Dysbiosis
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Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464 · see citing works
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Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation
Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421 · see citing works
Self-citationTitos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., & Clària, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100225 · Cited by 412 · see citing works
Metabolic Shifts in Immunity and Inflammation
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Identification of resolvin D2 receptor mediating resolution of infections and organ protection
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Self-citationChiurchiù, V., Leuti, A., Dalli, J., Jacobsson, A., Battistini, L., Maccarrone, M., & Serhan, C. N. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7483 · Cited by 356 · see citing works
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Chiang, N., & Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.005 · Cited by 330 · see citing works
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Current trends in inflammatory and immunomodulatory mediators in sepsis
Aziz, M., Jacob, A., Yang, W.-L., Matsuda, A., & Wang, P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912437 · Cited by 309 · see citing works
Hellmann, J. L., Tang, Y., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2011) · The FASEB Journal · doi:10.1096/fj.10-178657 · Cited by 306 · see citing works
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Self-citationOh, S. F., Pillai, P. S., Recchiuti, A., Yang, R., & Serhan, C. N. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42545 · Cited by 292 · see citing works
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Neutrophils in innate and adaptive immunity
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Dalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., & Serhan, C. N. (2013) · The FASEB Journal · doi:10.1096/fj.13-227728 · Cited by 283 · see citing works
Self-citationDong, X., Gao, J., Zhang, C. Y., Hayworth, C. R., Frank, M. G., & Wang, Z. (2019) · ACS Nano · doi:10.1021/acsnano.8b06572 · Cited by 276 · see citing works
Mas, E., Croft, K. D., Zahra, P., Barden, A., & Mori, T. A. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.190199 · Cited by 270 · see citing works
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Self-citationBento, A. F., Claudino, R. F., Dutra, R. C., Marcon, R., & Calixto, J. Β. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101305 · Cited by 258 · see citing works
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Hsiao, H.-M., Sapinoro, R., Thatcher, T. H., Croasdell, A., Levy, E. P., Fulton, R. A., Olsen, K. C., Pollock, S. J., Serhan, C. N., Phipps, R. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058258 · Cited by 212 · see citing works
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Gu, J., Luo, L., Wang, Q., Yan, S.-F., Lin, J., Li, D., Cao, B., Mei, H., Ying, B., Bin, L., et al. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0031-x · Cited by 189 · see citing works
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Bang, S., Yoo, S., Yang, T., Cho, H., Kim, Y., & Hwang, S. W. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00909.x · Cited by 176 · see citing works
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Jung, H. R., Sylvänne, T., Koistinen, K. M., Tarassov, K., Kauhanen, D., & Ekroos, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.025 · Cited by 168 · see citing works
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Calder, P. C., Adolph, M., Deutz, N. E., Grau, T., Innes, J. K., Klek, S., Lev, S., Mayer, K., Michael-Titus, A. T., Pradelli, L., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.032 · Cited by 158 · see citing works
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Calder, P. C. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120007077 · Cited by 154 · see citing works
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Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study
Frediani, J. K., Jones, D. P., Tukvadze, N., Uppal, K., Sanikidze, E., Kipiani, M., Tran, V., Hebbar, G., Walker, D. I., Kempker, R. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108854 · Cited by 151 · see citing works
Self-citation
- Authors
- Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N.
- Affiliations
- Brigham and Women's Hospital (US)
- Queen Mary University of London (GB)
- University of Southern California (US)
- Corresponding author
- Serhan, Charles N.
- ORCID
- Venue
- Nature
- Published
- 2009-10
- Volume
- 461
- Issue
- 7268
- Pages
- 1287-1291
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2779525
- OpenAlex
- W1974226247
- Cited by
- 695
- References
- 33
- Citations by year
- 2026: 21 · 2025: 19 · 2024: 35 · 2023: 34 · 2022: 42 · 2021: 49 · 2020: 61 · 2019: 40 · 2018: 40 · 2017: 44 · 2016: 54 · 2015: 45 · 2014: 39 · 2013: 50 · 2012: 48
- FWCI
- 38.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Funders
- Wellcome Trust (086867/Z/08/Z, 085903/Z/08)
- Versus Arthritis (18445, 18103)
- National Institutes of Health (4r37gm038765-19)
- National Heart, Lung, and Blood Institute (HL087526, F32HL087526)
- National Institute of General Medical Sciences (GM 38765, R01GM038765, R37-GM038765)
- National Institute of Dental and Craniofacial Research (P50DE016191)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- resolvin D2, inflammation resolution, neutrophil trafficking, leukocyte-endothelium interaction, nitric oxide, leukocyte adhesion molecules, cecal ligation and puncture, bacterial load, macrophage phagocytosis, anti-inflammatory agents, host defense
- MeSH terms
- Animals, Docosahexaenoic Acids, Escherichia coli, Humans, Inflammation, Leukocytes, Macrophages, Male, Mice, Inbred C57BL, Nitric Oxide, Peritoneal Cavity, Peritonitis, Phagocytosis, Reactive Oxygen Species, Sepsis, Endothelial Cells, Mice
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