The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14
Open accessAbstract
We have identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions. This opening improves access to receptors, for example, CD46 and Her2/neu, that are trapped in intercellular junctions. In addition to complete virions, dodecahedral particles (PtDds), formed by excess amounts of viral capsid proteins, penton base and fiber during viral replication, can trigger DSG-2–mediated opening of intercellular junctions as shown by studies with recombinant Ad3 PtDds. Our findings shed light on adenovirus biology and pathogenesis and may have implications for cancer therapy.
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Cites
Working out the strength and flexibility of desmosomes
Getsios, S., Huen, A. C., & Green, K. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1356 · Cited by 342
Turley, E. A., Veiseh, M., Radisky, D. C., & Bissell, M. J. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1089 · Cited by 253
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Adenovirus vectors for gene therapy, vaccination and cancer gene therapy
Wold, W., & Toth, K. (2014) · Current Gene Therapy · doi:10.2174/1566523213666131125095046 · Cited by 555
Cell–Cell Junctions Organize Structural and Signaling Networks
Garcia, M. A., Nelson, W. J., & Chavez, N. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029181 · Cited by 503
Watanabe, K., Luo, Y., Da, T., Guedan, S., Ruella, M., Scholler, J., Keith, B., Young, R. M., Engels, B., Sorsa, S., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99573 · Cited by 283
Self-citationStructure, function, and regulation of desmosomes
Kowalczyk, A. P., & Green, K. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394311-8.00005-4 · Cited by 270
Metadata
- Authors
- Wang, H., Li, Z.-Y., Liu, Y., Persson, J., Beyer, I., Möller, T., Koyuncu, D., Drescher, M. R., Strauss, R., Zhang, X.-B., Wahl, J. K., Urban, N., Drescher, C., Hemminki, A., Fender, P., & Lieber, A.
- Venue
- Nature Medicine
- Published
- 2010-12-12
- Volume
- 17
- Issue
- 1
- Pages
- 96-104
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1971765707
- Cited by
- 432
- References
- 2
- FWCI
- 16.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, H., Li, Z.-Y., Liu, Y., Persson, J., Beyer, I., Möller, T., Koyuncu, D., Drescher, M. R., Strauss, R., Zhang, X.-B., Wahl, J. K., Urban, N., Drescher, C., Hemminki, A., Fender, P., & Lieber, A. (2011). Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14. Nature Medicine. https://doi.org/10.1038/nm.2270
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