The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
Cell–Cell Junctions Organize Structural and Signaling Networks
Open accessAbstract
Cell-cell junctions link cells to each other in tissues, and regulate tissue homeostasis in critical cell processes that include tissue barrier function, cell proliferation, and migration. Defects in cell-cell junctions give rise to a wide range of tissue abnormalities that disrupt homeostasis and are common in genetic abnormalities and cancers. Here, we discuss the organization and function of cell-cell junctions primarily involved in adhesion (tight junction, adherens junction, and desmosomes) in two different epithelial tissues: a simple epithelium (intestine) and a stratified epithelium (epidermis). Studies in these tissues reveal similarities and differences in the organization and functions of different cell-cell junctions that meet the requirements for the specialized functions of each tissue. We discuss cell-cell junction responses to genetic and environmental perturbations that provide further insights into their roles in maintaining tissue homeostasis.
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Metadata
- Authors
- Garcia, M. A., Nelson, W. J., & Chavez, N.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-06-09
- Volume
- 10
- Issue
- 4
- Pages
- a029181
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2623796068
- Cited by
- 503
- References
- 257
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Garcia, M. A., Nelson, W. J., & Chavez, N. (2018). Cell–Cell Junctions Organize Structural and Signaling Networks. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a029181
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