Hypothalamic BDNF and obesity: found in translation
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BDNF affects the regulation of feeding and energy metabolism.
“BDNF is known to affect the regulation of feeding and energy metabolism [218–221].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [219]
Cites
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612 · see citing works
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J. E., Carnes, B. A., Brody, J. A., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000167407.83915.e7 · Cited by 1,944 · see citing works
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience · doi:10.1038/nn1073 · Cited by 896 · see citing works
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880 · see citing works
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High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 239 · see citing works
Leptin regulates the reward value of nutrient
Domingos, A. I., Vaynshteyn, J., Voss, H. U., Ren, X., Gradinaru, V., Zang, F., Deisseroth, K. A., de Araújo, I. E., & Friedman, J. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2977 · Cited by 230 · see citing works
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Bellinger, L. L., & Bernardis, L. L. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00756-4 · Cited by 228 · see citing works
Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
Liao, G., An, J. J., Gharami, K., Waterhouse, E. G., Vanevski, F., Jones, K. R., & Xu, B. (2012) · Nature Medicine · doi:10.1038/nm.2687 · Cited by 201 · see citing works
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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Lopresti, A. L., & Drummond, P. D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.005 · Cited by 231 · see citing works
Schéle, E., Grahnemo, L., Anesten, F., Hallén, A., Bäckhed, F., & Jansson, J.-O. (2013) · Endocrinology · doi:10.1210/en.2012-2151 · Cited by 209 · see citing works
- Authors
- Schwartz, E., & Mobbs, C. V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Mobbs, Charles V
- Venue
- Nature Medicine
- Published
- 2012-04
- Volume
- 18
- Issue
- 4
- Pages
- 496-497
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1987388085
- Cited by
- 25
- References
- 13
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 2
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brain-derived neurotrophic factor, hypothalamus, obesity, energy balance, feeding behavior, local protein translation, dendritic translation, neuroplasticity
- MeSH terms
- Animals, Dendrites, Energy Metabolism, Female, Humans, Male, RNA, Messenger, Brain-Derived Neurotrophic Factor, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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