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Cited by 468

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

Open access
Rehermann, Barbara·2013·Nature Medicine
DOI 10.1038/nm.3251
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Abstract

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a million deaths per year. Although HBV and HCV differ in their genome structures, replication strategies and life cycles, they have common features, including their noncytopathic nature and their capacity to induce chronic liver disease, which is thought to be immune mediated. However, the rate of disease progression from chronic hepatitis to cirrhosis varies greatly among infected individuals, and the factors that regulate it are largely unknown. This review summarizes our current understanding of the roles of antigen-specific and nonspecific immune cells in the pathogenesis of chronic hepatitis B and C and discusses recent findings that identify natural killer cells as regulators of T cell function and liver inflammation.

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Metadata

Authors
Rehermann, B.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2013-07
Volume
19
Issue
7
Pages
859-868
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3251
OpenAlex
W2091172564
Cited by
468
References
14
FWCI
39.13
Type
journal article
Language
en
Open access
green

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