Self-renewal as a therapeutic target in human colorectal cancer

Kreso, Antonija, van Galen, Peter, Pedley, Nicholas M, Lima-Fernandes, Evelyne, Frelin, Catherine, Davis, Thomas, Cao, Liangxian, Baiazitov, Ramil +12 more·2014·Nature Medicine
DOI 10.1038/nm.3418

Cited by (502)

Items 301–400 of 502

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  2. PTC209, a Specific Inhibitor of BMI1, Promotes Cell Cycle Arrest and Apoptosis in Cervical Cancer Cell Lines
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  3. Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader
    Md Kabir, Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A. Sidi, Kwang‐Su Park, Jian Jun Jin · 2024 · Journal of Medicinal Chemistry
  4. Mesenchymal stem cells-macrophages crosstalk and myeloid malignancy
    Kun Li, Hongyan Nie, Runming Jin, Xiaoyan Wu · 2024 · Frontiers in Immunology
  5. Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers
    Gennadi V. Glinsky · 2021 · Frontiers in Oncology
  6. Targeting Cancer Stem Cells through Epigenetic Modulation of Interferon Response
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  7. Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells
    Taronish D. Dubash, Christopher M. Hoffmann, Felix Oppel, Klara M. Giessler, Sarah Weber, Sebastian M. Dieter, Jennifer Hüllein, Thorsten Zenz, Friederike Herbst, Claudia Scholl et al. · 2015 · Cancer Letters
  8. Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer
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  9. BMI1 Roles in Cancer Stem Cells and Its Association with MicroRNAs Dysregulation in Cancer: Emphasis on Colorectal Cancer
    Mohammad Hasan Soheilifar, Abdolvahab Moshtaghian, Hamid Maadi, Fereshteh Izadi, Massoud Saidijam · 2018 · International Journal of Cancer Management
  10. Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
    Kaixin Wu, Seon Min Woo, Seung Un Seo, Taeg Kyu Kwon · 2021 · International Journal of Molecular Sciences
  11. Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer
    Xiaowei Zhang, Weijian Guo, Xiaofeng Wang, Xinyang Liu, Mingzhu Huang, Lu Gan, Yufan Cheng, Li Jin · 2016 · Oncotarget
  12. Lower Bmi-1 Expression May Predict Longer Survival of Colon Cancer Patients
    Xiaodong Li, Xiao Wei Zheng, Bin Xu, Dachuan Zhang, Yun Xu, Quanqin Xie, Wenwei Hu, Zhuojun Zheng, Yingjie Shao, Jun Wu et al. · 2016 · Cellular Physiology and Biochemistry
  13. Telomere Maintenance-Associated PML Is a Potential Specific Therapeutic Target of Human Colorectal Cancer
    Peng Gong, Hua Wang, Jingsong Zhang, Yudong Fu, Zhengmao Zhu, Jinmiao Wang, Yu Yin, Haiying Wang, Zhongcheng Zhou, Jiao Yang et al. · 2019 · Translational Oncology
  14. Convergent TP53 loss and evolvability in cancer
    Marcela Braga Mansur, Melvyn F. Greaves · 2023 · BMC Ecology and Evolution
  15. Getting to the Source: Selective Drug Targeting of Cancer Stem Cells
    Fatima Ismail, David Alan Winkler · 2014 · ChemMedChem
  16. Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata
    Yui Kaneta, Midori A. Arai, Naoki Ishikawa, Kazufumi Toume, Takashi Koyano, Thaworn Kowithayakorn, Tetsuhiro Chiba, Atsushi Iwama, Masami Ishibashi · 2017 · Journal of Natural Products
  17. Simultaneous elimination of cancer stem cells and bulk cancer cells by cationic-lipid-assisted nanoparticles for cancer therapy
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  18. Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice
    David John Cantor, Bryan King, Lili M. Blumenberg, Teresa DiMauro, Iannis Aifantis, Sergei B. Koralov, Jane A. Skok, Gregory David · 2019 · Cell Reports
  19. Long Noncoding RNA CBR3-AS1 Promotes Stem-like Properties and Oxaliplatin Resistance of Colorectal Cancer by Sponging miR-145-5p
    Liangbao Xie, Guangfei Cui, Tao Li · 2022 · Journal of Oncology
  20. Cancer Stem Cells of the Digestive System
    Hugh Shunsuke Colvin, Naohiro Nishida, Jun Koseki, Masamitsu Konno, K. Kawamoto, Kenta Tsunekuni, Yuuichiro Doki, Masaki Mori, Hideshi Ishii · 2014 · Japanese Journal of Clinical Oncology
  21. Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells
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  22. Subpopulations of cancer stem cells found in papillary thyroid carcinoma
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  23. Core-shell cisplatin/SiO2 nanocapsules combined with PTC-209 overcome chemotherapy–Acquired and intrinsic resistance in hepatocellular carcinoma
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  24. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells
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  25. Cancer Stem Cells as a Target Population for Drug Discovery
    Claire Bouvard, Colleen Barefield, Shoutian Zhu · 2014 · Future Medicinal Chemistry
  26. The clinicopathological and prognostic value of Nanog in human gastrointestinal luminal cancer: A meta-analysis
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  27. Bmi‐1 high‐expressing cells enrich cardiac stem/progenitor cells and respond to heart injury
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  28. PTC-209 Anti-Cancer Effects Involved the Inhibition of STAT3 Phosphorylation
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  29. Colorectal cancer stem cells crosstalk in tumor immune microenvironment and targeted therapeutic strategies
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  30. The kinase PERK represses translation of the G-protein–coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells
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  31. Polycomb Repressive Complexes: Shaping Pancreatic Beta-Cell Destiny in Development and Metabolic Disease
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  32. Enhanced DNA release from disulfide-containing layered nanocomplexes by heparin-electrostatic competition
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  36. A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
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  37. Targeting MUC1-C suppresses polycomb repressive complex 1 in multiple myeloma
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  38. BMI1 is downregulated by the natural compound curcumin, but not by bisdemethoxycurcumin and dimethoxycurcumin
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  41. Tumor Heterogeneity
    John W. Cassidy, Alejandra Bruna · 2017 · Elsevier eBooks
  42. Effects of a differentiating therapy on cancer-stem-cell-driven tumors
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  43. Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies
    Md. Ataur Rahman, Ehsanul Hoque Apu, S M Rakib-Uz-Zaman, Somdeepa Chakraborti, Sujay Kumar Bhajan, Shakila Afroz Taleb, Mushfiq Hassan Shaikh, Maroua Jalouli, Abdel Halim Harrath, Bonglee Kim · 2024 · Cells
  44. B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer
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  45. Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells
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  46. Epigenetic and Immune Regulation of Colorectal Cancer Stem Cells
    Amy V. Paschall, Kebin Liu · 2015 · Current Colorectal Cancer Reports
  47. Ovarian Cancer Recurrence: Role of Ovarian Stem Cells and Epithelial-to-Mesenchymal Transition
    Damia G Guffanti F · 2014 · Journal of Cancer Science & Therapy
  48. Development of PRC1 Inhibitors Employing Fragment-Based Approach and NMR-Guided Optimization
    Yiwu Yao, Miranda L. Simes, Weijiang Ying, Qingjie Zhao, Alyssa Winkler, Shirish Shukla, Felicia L. V. Gray, Caroline Nikolaidis, Geoffrey R. Hewett, Jolanta E. Grembecka et al. · 2025 · Journal of Medicinal Chemistry
  49. Hypoxic exposure activates the B cell‑specific Moloney murine leukaemia virus integration site 1/PI3K/Akt axis and promotes EMT in leukaemia stem cells
    Mingyan Jiang, Guoqian He, Jianhua Li, Jinrong Li, Xia Nan Guo, Ju Gao · 2020 · Oncology Letters
  50. Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death
    Nobuhiro Akita, Ryu Okada, Kyosuke Mukae, Ryuichi P. Sugino, Hisanori Takenobu, Koji Chikaraishi, Hidemasa Ochiai, Yohko Yamaguchi, Miki Ohira, Haruhiko Koseki et al. · 2022 · Experimental Cell Research
  51. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer.
    Nader Atlasy, Fardin Amidi, Keywan Mortezaee, Mohammad Sadegh Fazeli, Seyed Javad Mowla, Fatemeh Malek · 2019 · Europe PMC (PubMed Central)
  52. Regulation of gene transcription of B lymphoma Mo‑MLV insertion region 1 homolog (Review)
    Meizhen Zhou, Qichao Xu, Deqiang Huang, Lingyu Luo · 2021 · Biomedical Reports
  53. Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms
    Lia E. De Faveri, Carolyn D. Hurst, Jo‐An Roulson, Henry M. Wood, Marta Sänchez‐Carbayo, Margaret A. Knowles, Emma Chapman · 2015 · Translational Oncology
  54. CBX Chromodomain Inhibition Enhances Chemotherapy Response in Glioblastoma Multiforme.
    Katelyn E. Connelly, Emily C Martin, Emily C. Dykhuizen · 2016 · Europe PMC (PubMed Central)
  55. Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes
    Anna Palau, Anne-Kathrin Garz, Jeannine Diesch, Anabel Zwick, Roberto Malinverni, Vanesa Valero, Katrina M. Lappin, Raquel Casquero, Andreas Lennartsson, Johannes A. Zuber et al. · 2017 · Oncotarget
  56. RNA m 1 A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target
    Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu et al. · 2025 · 癌症：英文版
  57. Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance
    Shibnath Ghatak, Vincent Hascall, Nikos K. Karamanos, Roger R. Markwald, Suniti Misra · 2022 · Frontiers in Oncology
  58. Molecular targets for the treatment of AML in the forthcoming 5th World Health Organization Classification of Haematolymphoid Tumours
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  59. Variety in the Tumor Microenvironment: Integrin Splicing Regulates Stemness
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  60. Pluripotency markers are differentially induced by IGF1 and bFGF in cells from patients’ lesions of large/giant congenital melanocytic nevi
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  61. Co‑inhibition of BMI1 and Mel18 enhances chemosensitivity of esophageal squamous cell carcinoma in�vitro and in�vivo
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  62. Cancer Stem Cell Markers in Squamous Cell Carcinomas of the Salivary Glands
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