Self-renewal as a therapeutic target in human colorectal cancer

Kreso, Antonija, van Galen, Peter, Pedley, Nicholas M, Lima-Fernandes, Evelyne, Frelin, Catherine, Davis, Thomas, Cao, Liangxian, Baiazitov, Ramil +12 more·2014·Nature Medicine

Cited by (502)

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  9. Targeting self-renewal of cancer stem cells in colorectal cancer—a future treatment option?
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  18. Curbing self-renewal of cancer-initiating cells
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  19. Novel Targeted Therapies for Patients with Ovarian Cancer
    Samir A. Farghaly · 2014 · Journal of Cancer Science & Therapy
  20. Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis
    Lu Deng, Jiahui Xu, Dong Wang, Suling Liu · 2015 · Springer eBooks
  21. Breast Cancer Stem Cells: Role in Tumor Initiation, Progression, and Targeted Therapy
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  23. The Plasticity of Stem-Like States in Patient-Derived Tumor Xenografts
    Alastair Davies, Fraser D. Johnson, Kirsi Ketola, Amina Zoubeidi · 2017 · Molecular and translational medicine
  24. Polycomb Proteins in Hematopoiesis and Hematologic Malignancie
    Jie Li · 2017 · International Journal of Blood Research and Disorders
  25. Impact of circRNA on the complex regulatory network of the cell
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  26. Colorectal Cancer Stem Cells
    Pratima Nangia‐Makker, Yingjie Yu, Lulu Farhana, Kulsoom Ahmed, Adhip P.N. Majumdar · 2015 · Springer eBooks
  27. Cancer stem cells
    Md. Sabir Ali · 2022 · Elsevier eBooks
  28. ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer
    V. O. Tarakanova, N. V. Krakhmal, Станислав Викторович Паталяк, M. N. Tarasov, Бабышкина Наталия Николаевна, Sergey Vladimirovich Vtorushin · 2022 · Siberian Journal of Oncology
  29. SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2
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  30. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule
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  31. Bmi-1 serves as a potential novel marker for progression in human cutaneous basal cell carcinoma.
    Hongyan Zhu, Jian Wu, Xiaomei Cui, Xiaodong Chen · 2017 · PubMed Central
  32. Molecular Markers and Networks for Cancer and Stem Cells
    Shihori Tanabe · 2017 · Journal of Embryology & Stem Cell Research
  33. Applications of Machine Learning in Drug Discovery II: Biomarker Discovery, Patient Stratification and Pharmacoeconomics
    J. Cassidy · 2020 · Artificial Intelligence in Oncology Drug Discovery and Development
  34. Colon Stem Cells in Colorectal Cancer
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  35. Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment
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  36. Extracellular Proliferating Cell Nuclear Antigen as a Marker and Therapeutic Target for Cancer Stem Cells.
    Nathan Horton · 2014 · Digital Commons @ UNT Health Science Center
  37. Antibody therapy of cancer
    Mandy Gruijs · 2023
  38. Targeting Cancer Stem Cells and the Tumor Microenvironment
    Alice Turdo, Matilde Todaro, Giorgio Stassi · 2015 · Springer eBooks
  39. The Role of CBL Family of E3 Ubiquitin Ligases in Intestinal Epithelial Homeostasis
    Neha Zutshi · 2016 · DigitalCommons@UNMC
  40. Understanding Cancer Stem Cells Biology to Get Rid of Tumours
    José Bragança, Gisela Machado-Oliveira, Ivette Pacheco-Leyva, Ana Catarina Matias · 2015 · Springer eBooks
  41. Adjuvant Therapy After Resection of Metastatic Colorectal Cancer: Scant Evidence of a Curative Benefit.
    John Lindsay Marshall · 2016 · PubMed
  42. Chromatin silencing maintains the identity of intestinal stem cells
    Tianxin Yu, Chunming Liu · 2016 · Stem Cell Investigation
  43. Altered Chromatin Signaling in Cancer
    Andrew Scott Liss · 2016 · Elsevier eBooks
  44. High-Throughput Screening of Small Molecule Transcriptional Regulators in Embryonic Stem Cells Using qRT-PCR
    Emily C. Dykhuizen, Leigh Carmody, Nicola J. Tolliday · 2016 · Methods in pharmacology and toxicology
  45. Defining the Mode of Medulloblastoma Growth using the Ptch1 Heterozygous Mouse Model
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  46. Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype
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  47. Polycomb Proteins and their Roles in Skin Development and Regeneration
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  48. Glioma Stem Cells
    Chifumi Kitanaka · 2015 · Japanese Journal of Neurosurgery
  49. Colorectal Cancer Stem Cells
    S. Rehman, Jennifer Haynes, Evelyne Lima‐Fernandes, Angat Puri, Andrew Haller, Cherry Leung, Lauren Alicia Agro, Y. Wang, Catherine Adell O'Brien · 2016 · Elsevier eBooks
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    Allison M.L. Nixon · 2018 · TSpace (University of Toronto)
  51. Genetic and Chemical Genetic Approaches to Identifying Liabilities in Malignant Brain Cancer
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  52. Understanding Cancer Stem Cells Biology to Get Rid of Tumours
    José Bragança, Gisela Machado-Oliveira, Ivette Pacheco-Leyva, Ana Catarina Matias · 2019 · Springer eBooks
  53. Faculty Opinions recommendation of Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.
    Jean Clairambault · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  54. Genomic and Molecular Maps of Stemness and Malignant Regulatory Signatures
    Gennadi V. Glinsky · 2020 · ChemRxiv
  55. VEGF-B targeting by aryl hydrocarbon receptor mediates the migration and invasion of choriocarcinoma stem-like cells
    Qianxia Tan, Jingting Cai, Jingping Peng, Cui Hu, Chenchun Wu, Huining Liu · 2022 · Cancer Cell International
  56. An Analysis of Cancer Stem Cells’ Effectiveness in Curing Tumor and Possible Therapies
    Zibin Huang · 2022 · British Journal of Biology Studies
  57. PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion
    Natecia L. Williams, Lauren Hong, Maya Jaffe, Cara E. Shields, Karmella Ann Haynes · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Knockdown of BMI1 is sensitive to Paclitaxel in cervical and endometrial cancer
    Yiting Zhao, Yan Lin, Weili Yang, Jun Chen, Xiaofeng Jin · 2023 · Research Square
  59. Identification of the clinical prediction model and biomarkers based on chromatin regulators in colon cancer by integrated analysis of bulk- and single-cell RNA sequencing data
    Yichao Ma, Fang Fang, Kai Liao, Jingqiu Zhang, Wei Chen, Yiqun Liao, Bin Zhao, Yongkun Fang, Yuji Chen, Daorong Wang et al. · 2023 · Research Square
  60. Neoplasms – biological phenomenon
    JANUSZ A. MADEJ, Jakub Daniluk, Paweł Madej · 2023 · Medycyna Weterynaryjna
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  62. Evaluation of miR-330-3p and BMI1 Expression in Colorectal Cancer Patients, Healthy Adjacent Tissues, and Polypoid Adenomatous Lesions.
    Parviz Basiri, Saeid Afshar, Razieh Amini, Ali Reza Soltanian, Massoud Saidijam, Ali Mahdavinezhad · 2022 · PubMed Central
  63. INF2, an oncogenic protein in hepatocellular carcinoma (HCC)
    Haibiao Wang, Man Lin, Fusang Ye, Hong Li, Meng Ye, Jie Wang · 2024 · Research Square
  64. A model about regulation on three division modes of stem cell
    Qingxin Xie, Han Zhang, Maoxiang Wang, Kexun Yan, Fenglan Hu, Meng Xu · 2024 · Journal of Theoretical Biology
  65. Discovery and optimization of 4-(imidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine derivatives as novel phosphodiesterase 4 inhibitors
    Zongmin Wu, Furong Zhang, Zhexin Chen, Xue Wang, Xingfu Liu, Guofeng Yang, Sen Wang, Shuheng Huang, Hai‐Bin Luo, Yi‐You Huang et al. · 2024 · Molecular Diversity
  66. Histone H2A Ubiquitination Mediates the Establishment of Reactivation-Competent HSV-1 Latent Infection
    James Boehlke, Sara Anna Dochnal, Chandra Shekhar Misra, Alison K. Francois, Chris Boutell, Anna Ruth Cliffe · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Additional file 12 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  68. Additional file 8 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  69. Additional file 13 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  70. Additional file 4 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  71. Additional file 1 of VEGF-B targeting by aryl hydrocarbon receptor mediates the migration and invasion of choriocarcinoma stem-like cells
    Qianxia Tan, 蔡净亭, Peng, Jingping, Cui Hu, Chenchun Wu, Liu, Huining · 2022 · Figshare
  72. Additional file 15 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  73. Additional file 6 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  74. Additional file 8 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  75. Additional file 4 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  76. Additional file 11 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Han Zhang, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  77. Additional file 9 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  78. Additional file 16 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  79. Additional file 3 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  80. Additional file 1 of Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin
    Tung, Chia-Hao, Wu, Jia-En, Huang, Meng-Fan, Wang, Wen-Lung, Wu, Yi-Ying, Tsai, Yao-Tsung, Hsu, Xiu-Rui, Lin, Sheng-Hsiang, Chen, Yuh-Ling, Hong, Tse-Ming · 2023 · Figshare
  81. Additional file 2 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  82. Additional file 10 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  83. Additional file 14 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  84. Additional file 3 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  85. Additional file 5 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  86. Additional file 18 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  87. Additional file 9 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  88. Additional file 1 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  89. Additional file 7 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  90. Additional file 5 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  91. Additional file 6 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  92. Additional file 2 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  93. Additional file 7 of A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
    Sheng, Shuyan, Chen, Bangjie, Xu, Ruiyao, Yanxun Han, Mao, Deshen, Yuerong Chen, Conghan Li, Wenzhuo Su, Hu, Xinyang, Zhao, Qing et al. · 2024 · Figshare
  94. Additional file 1 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  95. Additional file 17 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  96. Additional file 10 of MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    Chen, Xu, Wang, Wei, Li, Yufang, Huo, Yi, Zhang, Han, Feng, Fan, Xi, Wenjin, Zhang, Tianze, Jinjian Gao, Yang, Fan et al. · 2021 · Figshare
  97. BAP1 loss impairs Non-Homologous End Joining DNA repair promoting genomic instability
    Sabrina Caporali, Carla Schuy, Alessio Butera, Melanie Rall-Scharpf, Nils Geese, Lisa Wiesmüller, Ivano Amelio · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  98. Nouvelles stratégies de sensibilisation des Cellules Souches Leucémiques en ciblant l’axe BCR-ABL/BMI1
    Fabien Muselli · 2020 · theses.fr (ABES)
  99. Caractérisation et ciblage thérapeutique de progéniteurs luminaux impliqués dans le cancer de la prostate résistant à la castration
    Manon Baurès · 2023
  100. Preclinical Drug-Response Profiling Identifies BMI1 Inhibition as a Therapeutic Option for Hepatoblastoma
    Salih Demir, Marie Friederike Bentrop, Alina Hotes, Tanja Schmid, Émilie Indersie, Sophie Branchereau, Christian Vokuhl, Beate Haeberle, Irene Schmid, Stefano Cairo et al. · 2026 · International Journal of Molecular Sciences