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Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

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Bernard, Sandra C, Simpson, Nandi, Join-Lambert, Olivier, Federici, Christian, Laran-Chich, Marie-Pierre, Maïssa, Nawal, Bouzinba-Ségard, Haniaa, Morand, Philippe C, Chretien, Fabrice, Taouji, Saïd, Chevet, Eric, Janel, Sébastien, Lafont, Frank, Coureuil, Mathieu, Segura, Audrey, Niedergang, Florence, Marullo, Stefano, Couraud, Pierre-Olivier, Nassif, Xavier, Bourdoulous, Sandrine·2014·Nature Medicine
DOI 10.1038/nm.3563
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Abstract

Neisseria meningitidis is a cause of meningitis epidemics worldwide and of rapidly progressing fatal septic shock. A crucial step in the pathogenesis of invasive meningococcal infections is the adhesion of bloodborne meningococci to both peripheral and brain endothelia, leading to major vascular dysfunction. Initial adhesion of pathogenic strains to endothelial cells relies on meningococcal type IV pili, but the endothelial receptor for bacterial adhesion remains unknown. Here, we report that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) or Basigin) is a critical host receptor for the meningococcal pilus components PilE and PilV. Interfering with this interaction potently inhibited the primary attachment of meningococci to human endothelial cells in vitro and prevented colonization of vessels in human brain tissue explants ex vivo and in humanized mice in vivo. These findings establish the molecular events by which meningococci target human endothelia, and they open new perspectives for treatment and prevention of meningococcus-induced vascular dysfunctions.

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Metadata

Authors
Bernard, S. C., Simpson, N., Join-Lambert, O., Federici, C., Laran-Chich, M.-P., Maïssa, N., Bouzinba-Ségard, H., Morand, P. C., Chretien, F., Taouji, S., Chevet, E., Janel, S., Lafont, F., Coureuil, M., Segura, A., Niedergang, F., Marullo, S., Couraud, P.-O., Nassif, X., & Bourdoulous, S.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-06-01
Volume
20
Issue
7
Pages
725-731
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3563
OpenAlex
W1994159005
Cited by
171
References
2
FWCI
12.92
Type
journal article
Language
en
Open access
green
Licence

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