The hCMEC/D3 cell line as a model of the human blood brain barrier

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325 · see citing works

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Lippmann, E. S., Azarin, S. M., Kay, J. E., Nessler, R. A., Wilson, H. K., Al-Ahmad, A., Palecek, S. P., & Shusta, E. V. (2012) · Nature Biotechnology · doi:10.1038/nbt.2247 · Cited by 800 · see citing works

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 793 · see citing works

Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study.

Butt, A. M., Jones, H. C., & Abbott, N. J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018243 · Cited by 775 · see citing works

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654 · see citing works

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

Hatherell, K. E., Couraud, P., Romero, I. A., Weksler, B. B., & Pilkington, G. J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.05.012 · Cited by 334 · see citing works

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier

Dauchy, S., Dutheil, F., Weaver, R. J., Chassoux, F., Daumas‐Duport, C., Couraud, P., Scherrmann, J., de Waziers, I., & Declèves, X. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05720.x · Cited by 331 · see citing works

The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies

Poller, B., Gutmann, H., Krähenbühl, S., Weksler, B. B., Romero, I. A., Couraud, P., Tuffin, G., Drewe, J., & Huwyler, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05730.x · Cited by 318 · see citing works

Differential effects of hydrocortisone and TNFα on tight junction proteins in an in vitro model of the human blood–brain barrier

Förster, C. Y., Burek, M., Romero, I. A., Weksler, B. B., Couraud, P., & Drenckhahn, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.146852 · Cited by 306 · see citing works

Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies

Cucullo, L., Couraud, P., Weksler, B. B., Romero, I. A., Hossain, M. K., Rapp, E., & Janigro, D. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600525 · Cited by 266 · see citing works

Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model

Ohtsuki, S., Ikeda, C., Uchida, Y., Sakamoto, Y., Miller, F., Glacial, F., Declèves, X., Scherrmann, J., Couraud, P., Kubo, Y., et al. (2012) · Molecular Pharmaceutics · doi:10.1021/mp3004308 · Cited by 231 · see citing works

Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium

Coureuil, M., Mikaty, G., Miller, F., Lécuyer, H., Bernard, C., Bourdoulous, S., Duménil, G., Mège, R., Weksler, B. B., Romero, I. A., et al. (2009) · Science · doi:10.1126/science.1173196 · Cited by 220 · see citing works

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

Urich, E., Lazic, S. E., Molnos, J., Wells, I., & Freskgård, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038149 · Cited by 220 · see citing works

Cell‐penetrating anti‐GFAP VHH and corresponding fluorescent fusion protein VHH‐GFP spontaneously cross the blood‐brain barrier and specifically recognize astrocytes: application to brain imaging

Li, T., Bourgeois, J., Celli, S., Glacial, F., Sourd, A. L., Mécheri, S., Weksler, B. B., Romero, I. A., Couraud, P., Rougeon, F., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-201384 · Cited by 202 · see citing works

Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications

Cristante, E., McArthur, S., Mauro, C., Maggioli, E., Romero, I. A., Wylezinska, M., Couraud, P. O., Lopez-Tremoleda, J., Christian, H., Weksler, B. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209362110 · Cited by 197 · see citing works

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

Dauchy, S., Miller, F., Couraud, P., Weaver, R. J., Weksler, B. B., Romero, I. A., Scherrmann, J., de Waziers, I., & Declèves, X. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.001 · Cited by 197 · see citing works

Solid Lipid Nanoparticles Enhance the Delivery of the HIV Protease Inhibitor, Atazanavir, by a Human Brain Endothelial Cell Line

Chattopadhyay, N., Zastre, J. A., Wong, H. L., Wu, X. Y., & Bendayan, R. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9615-2 · Cited by 194 · see citing works

Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium

Coureuil, M., Lécuyer, H., Scott, M. G. H., Boularan, C., Enslen, H., Soyer, M., Mikaty, G., Bourdoulous, S., Nassif, X., & Marullo, S. (2010) · Cell · doi:10.1016/j.cell.2010.11.035 · Cited by 191 · see citing works

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

Poller, B., Drewe, J., Krähenbühl, S., Huwyler, J., & Gutmann, H. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9431-1 · Cited by 184 · see citing works

Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells

Freese, C., Uboldi, C., Gibson, M. I., Unger, R. E., Weksler, B. B., Romero, I. A., Couraud, P., & Kirkpatrick, C. J. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-23 · Cited by 161 · see citing works

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

Lopez‐Ramirez, M. A., Fischer, R., Torres-Badillo, C. C., Davies, H. A., Logan, K. E., Pfizenmaier, K., Male, D. K., Sharrack, B., & Romero, I. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103460 · Cited by 140 · see citing works

Platelets Potentiate Brain Endothelial Alterations Induced byPlasmodium falciparum

Wassmer, S. C., Combes, V., Candal, F. J., Juhan-Vague, I., & Grau, G. E. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.645-653.2006 · Cited by 137 · see citing works

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

Candela, P., Gosselet, F., Saint‐Pol, J., Sevin, E., Boucau, M., Boulanger, É., Cecchelli, R., & Fénart, L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100462 · Cited by 136 · see citing works

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by <i>Cryptococcus neoformans</i>

Vu, K., Weksler, B., Romero, I., Couraud, P.-O., & Gelli, A. (2009) · Eukaryotic Cell · doi:10.1128/ec.00240-09 · Cited by 124 · see citing works

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

van Doorn, R., Pinheiro, M. A. L., Kooij, G., Lakeman, K. A. M., Hof, B. V. H., van der Pol, S. M. A., Geerts, D., van Horssen, J., van der Valk, P., van der Kam, E. L., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-133 · Cited by 124 · see citing works

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line.

Markoutsa, E., Pampalakis, G., Niarakis, A., Romero, I. A., Weksler, B., Couraud, P.-O., & Antimisiaris, S. G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.11.015 · Cited by 122 · see citing works

P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

Tai, L. M., Loughlin, J., Male, D. K., & Romero, I. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.42 · Cited by 119 · see citing works

Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood–brain barrier function

Sano, Y., Shimizu, F., Abe, M., Maeda, T., Kashiwamura, Y., Ohtsuki, S., Terasaki, T., Obinata, M., Kajiwara, K., Fujii, M., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22232 · Cited by 118 · see citing works

Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions

Jambou, R., Combes, V., Jambou, M.-J., Weksler, B. B., Couraud, P., & Grau, G. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001021 · Cited by 116 · see citing works

Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

Tai, L. M., Holloway, K., Male, D. K., Loughlin, J., & Romero, I. A. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00717.x · Cited by 115 · see citing works

CCL2 disrupts the adherens junction: implications for neuroinflammation

Roberts, T. K., Eugenin, E. A., Lopez, L., Romero, I. A., Weksler, B. B., Couraud, P.-O., & Berman, J. W. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.80 · Cited by 115 · see citing works

Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain.

El-Bachá, R. D. S., & Minn, A. (1999) · PubMed · Cited by 114 · see citing works

Alteration of Blood–Brain Barrier Integrity by Retroviral Infection

Afonso, P. V., Ozden, S., Cumont, M.-C., Seilhean, D., Cartier, L., Rezaie, P., Mason, S., Lambert, S., Huerre, M., Gessain, A., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000205 · Cited by 112 · see citing works

Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis

Subileau, E. A., Rezaie, P., Davies, H. A., Colyer, F. M., Greenwood, J., Male, D. K., & Romero, I. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318197eca7 · Cited by 111 · see citing works

Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling

Zhong, Y., Smart, E. J., Weksler, B. B., Couraud, P., Hennig, B., & Toborek, M. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0061-08.2008 · Cited by 111 · see citing works

PPARα and PPARγ attenuate HIV‐induced dysrégulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

Huang, W., Eum, S. Y., Andras, I. E., Hennig, B., & Toborek, M. J. (2009) · The FASEB Journal · doi:10.1096/fj.08-121624 · Cited by 109 · see citing works

Up‐regulation of P‐glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

Zastre, J. A., Chan, G. N. Y., Ronaldson, P. T., Ramaswamy, M., Couraud, P. O., Romero, I. A., Weksler, B. B., Bendayan, M., & Bendayan, R. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21898 · Cited by 108 · see citing works

GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC1Portions of this work were presented at the annual meeting of the Federation of the American Societies of Experimental Biology, April 17–21, 1999, Washington, DC [FASEB J. 13(4), 571.4A (1999)].1

Kannan, R., Chakrabarti, R., Tang, D., Kim, K. J., & Kaplowitz, N. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02184-8 · Cited by 99 · see citing works

Human Blood-Brain Barrier Disruption by Retroviral-Infected Lymphocytes: Role of Myosin Light Chain Kinase in Endothelial Tight-Junction Disorganization

Afonso, P. V., Ozden, S., Prévost, M., Schmitt, C., Seilhean, D., Weksler, B. B., Couraud, P., Antoine Gessain, A., Romero, I. A., & Ceccaldi, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2576 · Cited by 97 · see citing works

ABC and SLC Transporter Expression and Pot Substrate Characterization across the Human CMEC/D3 Blood−Brain Barrier Cell Line

Carl, S. M., Lindley, D. J., Couraud, P. O., Weksler, B. B., Romero, I. A., Mowery, S. A., & Knipp, G. T. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900178j · Cited by 97 · see citing works

Modulation of blood–brain barrier permeability by neutrophils: in vitro and in vivo studies

Joice, S. L., Mydeen, M. F. M., Couraud, P., Weksler, B. B., Romero, I. A., Fraser, P. A., & Easton, A. S. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.076 · Cited by 85 · see citing works

Lamotrigine is a substrate for OCT1 in brain endothelial cells

Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B. B., Romero, I. A., Couraud, P., & Pirmohamed, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.032 · Cited by 85 · see citing works

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid‐β variants in cells composing the cerebral vessel walls

Fossati, S., Cam, J. A., Meyerson, J. L., Mezhericher, E., Romero, I. A., Couraud, P., Weksler, B. B., Ghiso, J. A., & Rostagno, A. A. (2009) · The FASEB Journal · doi:10.1096/fj.09-139584 · Cited by 84 · see citing works

The association of statins plus LDL receptor‐targeted liposome‐encapsulated doxorubicin increases in vitro drug delivery across blood–brain barrier cells

Pinzón‐Daza, M. L., Garzón, R., Couraud, P., Romero, I. A., Weksler, B. B., Ghigo, D., Bosìa, A., & Riganti, C. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02103.x · Cited by 81 · see citing works

Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells

Prudhomme, J. G., Sherman, I. W., Land, K. M., Moses, A. V., Stenglein, S., & Nelson, J. A. (1996) · International Journal for Parasitology · doi:10.1016/0020-7519(96)00027-6 · Cited by 80 · see citing works

HIV-1 Tat Triggers Nuclear Localization of ZO-1 via Rho Signaling and cAMP Response Element-Binding Protein Activation

Zhong, Y., Zhang, B., Eum, S. Y., & Toborek, M. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4266-11.2012 · Cited by 79 · see citing works

Tissue-Type Plasminogen Activator Is a Regulator of Monocyte Diapedesis through the Brain Endothelial Barrier

Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Leyen, T. A., Hof, B. V. H., Couraud, P., Vivien, D., Dijkstra, C. D., & de Vries, H. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3567 · Cited by 75 · see citing works

Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood–brain barrier

Kusch-Poddar, M., Drewe, J., Fux, I., & Gutmann, H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.014 · Cited by 74 · see citing works

Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes

Viegas, P., Chaverot, N., Enslen, H., Perrière, N., Couraud, P., & Cazaubon, S. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03222 · Cited by 73 · see citing works

Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123

Tai, L. M., Reddy, P. S., Lopez‐Ramirez, M. A., Davies, H. A., Male, D. K., Loughlin, J., & Romero, I. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.039 · Cited by 67 · see citing works

Guanine Nucleotide-Binding Protein Gαi2: A New Partner of Claudin-5 that Regulates Tight Junction Integrity in Human Brain Endothelial Cells

Luissint, A., Fédérici, C., Guillonneau, F., Chrétien, F. C., Camoin, L., Glacial, F., Ganeshamoorthy, K., & Couraud, P. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.202 · Cited by 66 · see citing works

Beta amyloid effects on expression of multidrug efflux transporters in brain endothelial cells.

Kania, K., Wijesuriya, H. C., Hladky, S., & Barrand, M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.044 · Cited by 63 · see citing works

Regulation of Breast Cancer Resistant Protein by Peroxisome Proliferator-Activated Receptor α in Human Brain Microvessel Endothelial Cells

Hoque, M. T., Robillard, K. R., & Bendayan, R. (2012) · Molecular Pharmacology · doi:10.1124/mol.111.076745 · Cited by 63 · see citing works

Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line

Bahbouhi, B., Berthelot, L., Pettré, S., Michel, L., Wiertlewski, S., Weksler, B. B., Romero, I. A., Miller, F., Couraud, P., Brouard, S., et al. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008666 · Cited by 61 · see citing works

Intact Lipid Rafts Regulate HIV-1 Tat Protein-Induced Activation of the Rho Signaling and Upregulation of P-Glycoprotein in Brain Endothelial Cells

Zhong, Y., Hennig, B., & Toborek, M. J. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.214 · Cited by 59 · see citing works

HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin

Andras, I. E., Eum, S. Y., Huang, W., Zhong, Y., Hennig, B., & Toborek, M. J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.11.004 · Cited by 56 · see citing works

Establishment of a new conditionally immortalized cell line from human brain microvascular endothelial cells: A promising tool for human blood–brain barrier studies

Kamiichi, A., Furihata, T., Kishida, S., Ohta, Y., Saito, K., Kawamatsu, S., & Chiba, K. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.042 · Cited by 55 · see citing works

PPARα and PPARγ effectively protect against HIV‐induced inflammatory responses in brain endothelial cells

Huang, W., Rha, G. B., Han, M., Eum, S. Y., Andras, I. E., Zhong, Y., Hennig, B., & Toborek, M. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05626.x · Cited by 47 · see citing works

Two Strikingly Different Signaling Pathways Are Induced by Meningococcal Type IV Pili on Endothelial and Epithelial Cells

Lécuyer, H., Nassif, X., & Coureuil, M. (2011) · Infection and Immunity · doi:10.1128/iai.05837-11 · Cited by 46 · see citing works

Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

Andras, I. E., Rha, G. B., Huang, W., Eum, S. Y., Couraud, P., Romero, I. A., Hennig, B., & Toborek, M. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.042028 · Cited by 44 · see citing works

Evaluation of Soluble Junctional Adhesion Molecule-A as a Biomarker of Human Brain Endothelial Barrier Breakdown

Haarmann, A., Deiß, A., Prochaska, J. H., Foerch, C., Weksler, B. B., Romero, I. A., Couraud, P., Stoll, G., Rieckmann, P., & Buttmann, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013568 · Cited by 44 · see citing works

Metabolic Acidosis Induced by Plasmodium Falciparum Intraerythrocytic Stages Alters Blood—Brain Barrier Integrity

Zougbédé, S., Miller, F., Ravassard, P., Rebollo, A., Cicéron, L., Couraud, P., Mazier, D., & Sabater, A. M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.121 · Cited by 44 · see citing works

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells*

Hernández-Guillamon, M., Mawhirt, S., Fossati, S., Blais, S., Parés, M., Penalba, A., Boada, M., Couraud, P., Neubert, T., Montaner, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135228 · Cited by 43 · see citing works

HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level

Andras, I. E., & Toborek, M. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-185-7_26 · Cited by 41 · see citing works

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro

Chaitanya, G. V., Cromer, W. E., Wells, S., Jennings, M. H., Couraud, P., Romero, I. A., Weksler, B. B., Erdreich‐Epstein, A., Mathis, J. M., Minagar, A., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-162 · Cited by 40 · see citing works

Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3

Fasler‐Kan, E., Suenderhauf, C., Barteneva, N. S., Poller, B., Gygax, D., & Huwyler, J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.077 · Cited by 36 · see citing works

Diesel exhaust particles increase IL-1β-induced human β-defensin expression via NF-κB-mediated pathway in human lung epithelial cells

Nam, H. Y., Ahn, E., Kim, H. J., Lim, Y., Lee, C. B., Lee, K. Y., & Vallyathan, V. (2006) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-3-9 · Cited by 29 · see citing works

Neutrophils block permeability increases induced by oxygen glucose deprivation in a culture model of the human blood–brain barrier

Cowan, K. M., & Easton, A. S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.066 · Cited by 27 · see citing works

The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood–brain barrier: Evidence for involvement of breast cancer resistance protein

Watson, C., Dogruel, M., Mihoreanu, L., Begley, D. J., Weksler, B. B., Couraud, P. O., Romero, I. A., & Thomas, S. A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.053 · Cited by 25 · see citing works

NKIM-6, a new immortalized human brain capillary endothelial cell line with conserved endothelial characteristics

Ketabi‐Kiyanvash, N., Herold‐Mende, C. C., Kashfi, F., Caldeira, S., Tommasino, M., Haefeli, W. E., & Weiß, J. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0348-4 · Cited by 22 · see citing works

Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells

Huang, W., Rha, G. B., Chen, L., Seelbach, M. J., Zhang, B., Andras, I. E., Bruemmer, D., Hennig, B., & Toborek, M. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01126.2009 · Cited by 22 · see citing works

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment

Hurst, L. A., Bunning, R. A. D., Couraud, P., Romero, I. A., Weksler, B. B., Sharrack, B., & Woodroofe, M. N. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.008 · Cited by 22 · see citing works

The Involvement of a Na+- and Cl–-Dependent Transporter in the Brain Uptake of Amantadine and Rimantadine

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CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development

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Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout

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