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Cited by 477

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Open access
Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A, Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I, Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W, Axthelm, Michael K, Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M, Edlefsen, Paul T, Piatak, Michael, Estes, Jacob D, Lifson, Jeffrey D, Picker, Louis J·2015·Nature Medicine
DOI 10.1038/nm.3781
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Abstract

Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but sufficient viral replication persists in EC tissues to allow viral sequence evolution and induce excess immune activation. Here we show that productive SIV infection in rhesus monkey ECs, but not TPs, is markedly restricted to CD4+ follicular helper T (TFH) cells, suggesting that these EC monkeys' highly effective SIV-specific CD8+ T cells can effectively clear productive SIV infection from extrafollicular sites, but their relative exclusion from B cell follicles prevents their elimination of productively infected TFH cells. CD8+ lymphocyte depletion in EC monkeys resulted in a dramatic re-distribution of productive SIV infection to non-TFH cells, with restriction of productive infection to TFH cells resuming upon CD8+ T cell recovery. Thus, B cell follicles constitute 'sanctuaries' for persistent SIV replication in the presence of potent anti-viral CD8+ T cell responses, potentially complicating efforts to cure HIV infection with therapeutic vaccination or T cell immunotherapy.

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Metadata

Authors
Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M. K., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. D., Lifson, J. D., & Picker, L. J.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2015-01-19
Volume
21
Issue
2
Pages
132-139
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3781
OpenAlex
W2026547100
Cited by
477
References
42
FWCI
37.64
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. https://app.cochat.ai/papers/10.1038/nm.3781
The paper
Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M. K., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., . . . Picker, L. J. (2015). B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nature Medicine. https://doi.org/10.1038/nm.3781

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.