The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Yun-Hee, Nguyen, Kim Y, Grant, Ryan W, Goldberg, Emily L, Bodogai, Monica, Kim, Dongin, D'Agostino, Dominic, Planavsky, Noah +9 more·2015·Nature Medicine

DOI 10.1038/nm.3804

Cited by (1,001)

Items 901–1,000 of 1,001

Dietary ketone body–escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia
Sisi Xie, Chenyu Jiang, Meng Ying Wu, Ying Ye, Biying Wu, Xiaoting Sun, Xue Lv, Ruibo Chen, Wen Yu, Qi Sun et al. · 2022 · Science Translational Medicine
Calponin 2 regulates ketogenesis to mitigate acute kidney injury
Yuan Gui, Zachary Palanza, Priya Gupta, Hanwen Li, Yuchen Pan, Yuanyuan Wang, Geneva R. Hargis, Donald L. Kreutzer, Yanlin Wang, Sheldon Bastacky et al. · 2023 · JCI Insight
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner
Anke Geng, Jiahui Sun, Huanyin Tang, Yang Yu, Xiyue Wang, Jingyuan Zhang, Xiaona Wang, Xiaoxiang Sun, Xiaofang Zhou, Neng Gao et al. · 2024 · Nucleic Acids Research
Medical nutrition therapy for the management of type 2 diabetes mellitus
Luigi Barrea, Ludovica Verde, Annamaria Colao, Lawrence J. Mandarino, Giovanna Muscogiuri · 2025 · Nature Reviews Endocrinology
The interplay between metabolism and neuroinflammation in epilepsy: mechanisms and therapeutic perspectives
Leqing Xu, Zhao Zhao, Yufei Zhang, Chun-Lai Ma · 2025 · Journal of Neuroinflammation
Ketogenic Diet and Cancer—a Perspective
Christopher Smyl · 2016 · Recent results in cancer research/Recent Results in Cancer Research
Nutrition and exercise in Pompe disease
Mark Andrew Tarnopolsky, Mats Inge Nilsson · 2019 · Annals of Translational Medicine
1,3-Butanediol attenuates hypertension and suppresses kidney injury in female rats
Jeanne Ishimwe, Michael R. Garrett, Jennifer M. Sasser · 2020 · American Journal of Physiology-Renal Physiology
Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act
Xujun Cao, Anthony F. Cordova, Lingyin Li · 2021 · Chemical Reviews
Auditory and Vestibular Characteristics of NLRP3 Inflammasome Related Autoinflammatory Disorders: Monogenic Hearing Loss Can Be Improved by Anti-interleukin-1 Therapy
Hiroshi Nakanishi, Satoshi Yamada, Junya Kita, Daichi Shinmura, Kumiko Hosokawa, Sosuke Sahara, Kiyoshi Misawa · 2022 · Frontiers in Neurology
RETRACTED: Diacetylrhein, an anthraquinone antiarthritic agent, suppresses dextran sodium sulfate-induced inflammation in rats: A possible mechanism for a protective effect against ulcerative colitis
Mona H. Zohny, Mohammed Alrouji, Sharif H. Alhajlah, Othman AlOmeir, Mohamed G. Ewees, Dalia M Abdel Ghaffar, Noura El Adle Khalaf, Osama A. Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Waleed Barakat El-Bahouty et al. · 2022 · Biomedicine & Pharmacotherapy · Retracted
Inflammasomes and their roles in arthritic disease pathogenesis
Gabsik Yang, Han Chang Kang, Yong‐Yeon Cho, Hye Suk Lee, Joo Young Lee · 2022 · Frontiers in Molecular Biosciences
Butyrate Ameliorates Intraocular Bacterial Infection by Promoting Autophagy and Attenuating the Inflammatory Response
Sukhvinder Singh, Pawan Kumar Singh, Ashok Kumar · 2022 · Infection and Immunity
Exogenous Ketone Supplementation Decreased the Lipopolysaccharide-Induced Increase in Absence Epileptic Activity in Wistar Albino Glaxo Rijswijk Rats
Zsolt Kovács, Dominic P. D’Agostino, David M. Diamond, Csilla Ari · 2019 · Frontiers in Molecular Neuroscience
Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides
Arumay Pal, Kurt Neo, Rajamani Lakshminarayanan, Fernando Jose Ferrer, David Philip Lane, Chandra Shekhar Verma, Alessandra Mortellaro · 2019 · Scientific Reports
Opportunities for future therapeutic interventions for hyperoxaluria: targeting oxidative stress
Sunil N Joshi, Saeed R. Khan · 2019 · Expert Opinion on Therapeutic Targets
Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease?
Lívia Alvarenga, L. Cardozo, Natália Alvarenga Borges, Bengt Lindholm, Peter Stenvinkel, Paul G. Shiels, Denis P. Fouque, Denise Mafra · 2020 · Food Research International
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen
Gesa J. Albers, Christina Michalaki, Patricia P. Ogger, Amy F. Lloyd, Benjamin Causton, Simone A. Walker, Anna Caldwell, John M. Halket, Linda V. Sinclair, Sarah H. Forde et al. · 2024 · Mucosal Immunology
Role of inflammasomes in acute respiratory distress syndrome
Luke Flower, Emilio G. Vozza, Clare Elizabeth Bryant, Charlotte Summers · 2025 · Thorax
Metabolic regulation of immunological aging
Hee‐Hoon Kim, Vishwa Deep Dixit · 2025 · Nature Aging
An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods
Jessica L. Turton, Grant David Brinkworth, Rowena Field, Helen M. Parker, Kieron B. Rooney · 2019 · Diabetes Obesity and Metabolism
Ketotherapeutics for neurodegenerative diseases
Nicholas G. Norwitz, Javier Gilbert‐Jaramillo, Kieran Clarke, Adrián Soto-Mota · 2020 · International review of neurobiology
Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models
Csilla Ari, Cem Murdun, Craig R. Goldhagen, Andrew Paul Koutnik, Sahil Bharwani, David M. Diamond, Mark S. Kindy, Dominic P. D’Agostino, Zsolt Kovács · 2020 · Nutrients
Stress increases blood beta‐hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model
Tsuyoshi Nishiguchi, Masaaki Iwata, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Shumei Murakami, Yumeto Nakada, Shenghong Pu, Yuki Shimizu, Tatsuya Tsubakino et al. · 2021 · Neuropsychopharmacology Reports
Ketogenic diets and the nervous system: a scoping review of neurological outcomes from nutritional ketosis in animal studies
Rowena Field, Tara Field, Fereshteh Pourkazemi, Kieron B. Rooney · 2021 · Nutrition Research Reviews
Walking down Skeletal Muscle Lane: From Inflammasome to Disease
Nicolas Dubuisson, Romain Versele, María A. Davis‐López de Carrizosa, Camille M. Selvais, Sonia M. Brichard, Michel Abou‐Samra · 2021 · Cells
Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r - and s -ß-Hydroxybutyrate Concentrations in Healthy Adults
Christopher D. Crabtree, Thanh Blade, Parker N. Hyde, Alex Buga, Madison L. Kackley, Teryn N. Sapper, Oishika Panda, Stephanie Roa Diaz, Joshua C. Anthony, John C. Newman et al. · 2022 · Journal of the American Nutrition Association
Human fasting modulates macrophage function and upregulates multiple bioactive metabolites that extend lifespan in Caenorhabditis elegans: a pilot clinical study
Christopher H. Rhodes, Chenghao Zhu, Joanne Agus, Xinyu Tang, Qianyan Li, JoAnne Engebrecht, Angela M. Zivkovic · 2022 · American Journal of Clinical Nutrition
Alleviative effect of poly-β-hydroxybutyrate on lipopolysaccharide-induced oxidative stress, inflammation and cell apoptosis in Cyprinus carpio
Liang Li, Xiao-Fang Wei, Zhi-Yong Yang, Rui Zhu, Deng‐Lai Li, Guo-Jun Shang, Hao-Tong Wang, Si-Tong Meng, Yin-Tao Wang, Siying Liu et al. · 2023 · International Journal of Biological Macromolecules
Dysregulation of inflammasome activation in glioma
JeongMin Sim, JeongMan Park, Jong‐Seok Moon, Jaejoon Lim · 2023 · Cell Communication and Signaling
Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD)
Damian Dyńka, Łukasz Rodzeń, Mateusz Rodzeń, Dorota Łojko, Sebastian Kraszewski, Ali Ibrahim, Maria Hussey, Adam Deptuła, Żaneta Grzywacz, A. Ternianov et al. · 2024 · Journal of Clinical Medicine
Adipositas und chronische Inflammation bei phlebologischen und lymphologischen Erkrankungen
Gabriele Faerber · 2018 · Phlebologie
Treatment with the Ketone Body D-β-hydroxybutyrate Attenuates Autophagy Activated by NMDA and Reduces Excitotoxic Neuronal Damage in the Rat Striatum In Vivo
Teresa Montiel, Luis A. Montes-Ortega, Susana Flores-Yáñez, Lourdes Massieu · 2020 · Current Pharmaceutical Design
Characterization of a high-resolution breath acetone meter for ketosis monitoring
Donald J. Suntrup, Timothy V. Ratto, Matt Ratto, James P. McCarter · 2020 · PeerJ
Overview of the Gut–Brain Axis: From Gut to Brain and Back Again
Zoë Post, Richard A. Manfready, A. Keshavarzian · 2023 · Seminars in neurology
Metabolomics‐driven discovery of therapeutic targets for cancer cachexia
Pengfei Cui, Xiaoyi Li, Caihua Huang, Donghai Lin · 2024 · Journal of Cachexia Sarcopenia and Muscle
Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson’s disease
Éva M. Szegő, Lennart Höfs, Anna Antoniou, Elisabeth Dinter, Nadine Rabe Bernhardt, Anja Schneider, Donato A. Di Monte, Björn H. Falkenburger · 2025 · Nature Communications
A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma
L J Amaral, Gillian K. Gresham, Sungjin Kim, Mourad Tighiouart, Thomas Allen Nelson, Amelia Welborn, Laura Lockshon, Brandon Noorvash, Jeremy David Rudnick, Scott A. Irwin et al. · 2025 · Scientific Reports
Melanoma—Time to fast or time to feast? An interplay between PPARs, metabolism and immunity
Maja Grabacka, Przemyslaw Mieszko Plonka, Krzysztof Reiss F · 2020 · Experimental Dermatology
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness
Kim Han, Komudi Singh, Matthew J. Rodman, Shahin Hassanzadeh, Yvonne Baumer, Rebecca D. Huffstutler, Jinguo Chen, Julián Candia, Foo Cheung, Katherine E. Stagliano et al. · 2021 · Nutrients
Is there any role of intermittent fasting in the prevention and improving clinical outcomes of COVID-19?: intersection between inflammation, mTOR pathway, autophagy and calorie restriction
Martin L. Gnoni, Renato Beas, Raúl Vásquez-Garagatti · 2021 · VirusDisease
Depressive symptoms improve over 2 years of type 2 diabetes treatment via a digital continuous remote care intervention focused on carbohydrate restriction
Rebecca N. Adams, Shaminie J. Athinarayanan, Amy L. McKenzie, Sarah J. Hallberg, James P. McCarter, Stephen D. Phinney, Jeffrey S. Gonzalez · 2022 · Journal of Behavioral Medicine
Identification of NLRP3PYD Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity
Soroush Moasses Ghafary, Paula M. Soriano‐Teruel, Shima Lotfollahzadeh, Mónica Sancho, Eva Serrano‐Candelas, Fatemeh Karami, Stephen J. Barigye, Iván Fernández-Pérez, Rafael Gozalbes, Maryam Nikkhah et al. · 2022 · International Journal of Molecular Sciences
The Anti‐Inflammatory Effect of Preventive Intervention with Ketogenic Diet Mediated by the Histone Acetylation of mGluR5 Promotor Region in Rat Parkinson’s Disease Model: A Dual‐Tracer PET Study
Yuankai Zhu, Xiangyu Tang, Zhaoting Cheng, Qingjian Dong, Ge Ruan · 2022 · Parkinson s Disease
Acetoacetate Improves Memory in Alzheimer’s Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation
Xiaojun Wu, Qin‐Qin Shu, Bin Wang, Lan Dong, Bin Hao · 2022 · American Journal of Alzheimer s Disease & Other Dementias®
The ketogenic diet could improve the efficacy of curcumin and Oldenlandia diffusa extract in the treatment of gastric cancer by increasing miR340 expression and apoptosis mediated by autophagy, oxidative stress, and angiogenesis
Qiuju Xiao, Bo Deng, Abolfazl Akbari, Qisheng Liu, Bisheng Zhu · 2022 · Journal of Food Biochemistry
β-Hydroxybutyrate Regulates Activated Microglia to Alleviate Neurodegenerative Processes in Neurological Diseases: A Scoping Review
Siva Shantini Jayashankar, Khaizurin Tajul Arifin, Muhammad Luqman Nasaruddin · 2023 · Nutrients
Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative Stress Involving Gliflozins and Sirtuins
Raúl Lelio Sanz, Felipe Inserra, Sebastián García Menéndez, Luciana Jorgelina Mazzei, León Ferder, Walter A. Manucha · 2023 · Current Hypertension Reports
Oxidative stress and inflammation: the root causes of aging
Prasert Sobhon, Gavin Savedvanich, Sawaek Weerakiet · 2023 · Exploration of Medicine
Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility
H. Abdallah, M. Khalil, Ilaria Farella, Jerlin Stephy JohnBritto, Elisa Lanza, S. Santoro, G. Garruti, P. Portincasa, A. Di Ciaula, L. Bonfrate · 2023 · European Journal of Clinical Investigation
Modulation of the autophagy‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke
Teresa Montiel, Juan Carlos Gómora‐García, Cristian Gerónimo‐Olvera, Yessica Heras‐Romero, Berenice N. Bernal‐Vicente, Xochitl Pérez-Martı́nez, Luis B. Tovar‐y‐Romo, Lourdes Massieu · 2023 · Journal of Neurochemistry
Ketogenic Diet as a Possible Non-pharmacological Therapy in Main Endocrine Diseases of the Female Reproductive System: A Practical Guide for Nutritionists
Elisabetta Camajani, Alessandra Feraco, Ludovica Verde, Eleonora Moriconi, Marco Marchetti, Annamaria Colao, Massimiliano Caprio, Giovanna Muscogiuri, Luigi Barrea · 2023 · Current Obesity Reports
The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer
Marisabel Mecca, Simona Picerno, Salvatore Cortellino · 2024 · International Journal of Molecular Sciences
Beta-Hydroxybutyrate Mitigates Sensorimotor and Cognitive Impairments in a Photothrombosis-Induced Ischemic Stroke in Mice
Artem P. Gureev, Irina S. Sadovnikova, Ekaterina V. Chernyshova, Arina D. Tsvetkova, Polina I. Babenkova, Veronika V. Nesterova, Ekaterina P. Krutskikh, Daria E. Volodina, Natalia A. Samoylova, Nadezda V. Andrianova et al. · 2024 · International Journal of Molecular Sciences
Problems and Opportunities in the use of Bioelectrical Impedance Analysis for Assessing Body Composition During Ketogenic Diets: A Scoping Review
Antonio Paoli, Francesco Campa · 2024 · Current Obesity Reports
Transcriptome Analyses of Heart and Liver Reveal Novel Pathways for Regulating Songbird Migration
William J. Horton, Matthew Jensen, Aswathy Sebastian, Craig A. Praul, Istvan U. Albert, Paul A. Bartell · 2019 · Scientific Reports
Reframing Nutritional Microbiota Studies To Reflect an Inherent Metabolic Flexibility of the Human Gut: a Narrative Review Focusing on High-Fat Diets
Jonathan Sholl, Lucy J. Mailing, Thomas Ragnar Wood · 2021 · mBio
Ketone bodies as chemical signals for the immune system
Michelangelo Bauwelz Gonzatti, Emily L. Goldberg · 2024 · American Journal of Physiology-Cell Physiology
Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity
Chen He, Junkai Liu, Junda Li, Hongyu Wu, Chenyang Jiao, Xiaotong Ze, Shengtao Xu, Zheying Zhu, Wenjie Guo, Jinyi Xu et al. · 2024 · Journal of Medicinal Chemistry
The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial
Aryan Tavakoli, Camellia Akhgarjand, Hastimansooreh Ansar, Hirad Houjaghani, Amirhossein Khormani, Kurosh Djafarian, Abdolrahman Rostamian, Mahsa Ranjbar, Gholamreza Mohammadi Farsani · 2025 · Scientific Reports
Comparison of lactate and β-hydroxybutyrate in the treatment of concanavalin-A induced hepatitis
Sara H. Hazem, Mohamed F. Hamed, Mohamed A. Saad, Nariman M. Gameil · 2018 · International Immunopharmacology
Cardiorenal Protection in Diabetic Kidney Disease
Jason F. Lee, Ecaterina Berzan, Vikas S. Sridhar, Ayodele Odutayo, David Z.I. Cherney · 2021 · Endocrinology and Metabolism
Hypothesis: Febrile infection‐related epilepsy syndrome is a microglial NLRP3 inflammasome/IL‐1 axis‐driven autoinflammatory syndrome
Wei‐Sheng Lin, Ting‐Rong Hsu · 2021 · Clinical & Translational Immunology
Epigenetic Inactivation of Acetyl-CoA Acetyltransferase 1 Promotes the Proliferation and Metastasis in Nasopharyngeal Carcinoma by Blocking Ketogenesis
Yunliang Lu, Xiaohui Zhou, Weilin Zhao, Zhipeng Liao, Bo Li, Peipei Han, Yanping Yang, Xuemin Zhong, Yingxi Mo, Ping Li et al. · 2021 · Frontiers in Oncology
The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer’s Disease
Mahdieh Golzari-Sorkheh, Carla E. Brown, Donald Fredric Weaver, Mark A. Reed · 2021 · Journal of Alzheimer s Disease
3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mi Kyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha · 2022 · Antioxidants
Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation
Naveen Challagundla, Bhaskar Saha, Reena Agrawal-Rajput · 2022 · Immunologic Research
ß-Hydroxybutyrate Improves Mitochondrial Function After Transient Ischemia in the Mouse
Alina Lehto, Konrad A. Koch, Johanna Barnstorf-Brandes, Christian Viel, Marius Fuchs, Jochen Klein · 2022 · Neurochemical Research
Inflammasomes: Cause or consequence of obesity‐associated comorbidities in humans
Aura Dulcinea Herrera-Martínez, Vicente Herrero‐Aguayo, Jesús M. Pérez‐Gómez, Manuel David Gahete, Raul Miguel Luque · 2022 · Obesity
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis
Hong Jiang, Ziyu Bai, Yongyu Ou, Huiling Liu, Zi-lin Si, Yafang Liu, Xiaoqiong Liu, Xiaoqing Liu, Zhihao Zhang, Ning‐Hua Tan · 2022 · Journal of Ethnopharmacology
The effect of the ketogenic diet on Acne: Could it be a therapeutic tool?
Luigi Barrea, Sara Cacciapuoti, Matteo Megna, Ludovica Verde, Claudio Marasca, Rosa Vono, Elisabetta Camajani, Annamaria Colao, Silvia Savastano, Gabriella Fabbrocini et al. · 2023 · Critical Reviews in Food Science and Nutrition
The proteomic effects of ketone bodies: implications for proteostasis and brain proteinopathies
Lizbeth García‐Velázquez, Lourdes Massieu · 2023 · Frontiers in Molecular Neuroscience
Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model
Alexandre Kléber Silveira, Henrique Mautone Gomes, Nicole Taís Fröhlich, Luana dos Reis Possa, Lucas Fabrício da Silva Santos¹, Flávio Gabriel Carazza Kessler, Alberto Martins, Matheus Scarpatto Rodrigues, Jade de Oliveira, Natália Duarte do Nascimento et al. · 2023 · Immunological Investigations
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke
Xin‐Yuan Guan, Dasha Wei, Zhuangzhuang Liang, Luyang Xie, Yifang Wang, Zhangjian Huang, Jin Chuan Wu, Tao Pang · 2023 · ACS Chemical Neuroscience
NLRP3 inflammatory pathway. Can we unlock depression?
Ghazaleh Ghaffaripour Jahromi, Sepideh Razi, Nima Rezaei · 2023 · Brain Research
Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β -hydroxybutyrate in gut environments
Daye Mun, Minkyoung Kang, Minhye Shin, Hye‐Jin Choi, Anna Kang, Sangdon Ryu, Tatsuya Unno, Brighton E. Maburutse, Sangnam Oh, Younghoon Kim · 2023 · Microbiology Spectrum
Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes
Helena Neudorf, Hashim Islam, Kaja Falkenhain, Bárbara Oliveira, Garett S. Jackson, Alfonso Moreno‐Cabañas, Kenneth Michael Madden, Joel Singer, Jeremy James Walsh, Jonathan P. Little · 2024 · Clinical & Experimental Immunology
Manipulation of Inflammasome: A Promising Approach Towards Immunotherapy of Lung Cancer
Rupak Dey Sarkar, Samraj Sinha, Nabendu Biswas · 2021 · International Reviews of Immunology
Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
Tyler Kent Ulland, Andrea C. Ewald, Andrew O. Knutson, Kaitlyn M. Marino, Stephanie M. C. Smith, Jyoti J. Watters · 2021 · Cells
A Potential Role for the Ketogenic Diet in Alzheimer’s Disease Treatment: Exploring Pre-Clinical and Clinical Evidence
Tadeu P. D. Oliveira, Ana L. B. Morais, Pedro L. Bessa dos Reis, András Palotás, Luciene Bruno Vieira · 2023 · Metabolites
Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation
Alisha Niskala, Jordi Heijman, Dobromir Dobrev, Thomas Jespersen, Arnela Saljic · 2024 · British Journal of Pharmacology
Unraveling the Translational Relevance of β-Hydroxybutyrate as an Intermediate Metabolite and Signaling Molecule
Dwifrista Vani Pali, Sujin Kim, Keren Esther Kristina Mantik, Ju-Bi Lee, Chi So, Sohee Moon, Dong‐Ho Park, Hyo‐Bum Kwak, Ju‐Hee Kang · 2025 · International Journal of Molecular Sciences
Clinical Observation of a Novel, Complementary, Immunotherapeutic Approach based on Ketogenic Diet, Chondroitin Sulfate, Vitamin D3, Oleic Acid and a Fermented Milk and Colostrum Product
Michael Schwalb, Margit Taubmann, Steve Hines, Heinz Reinwald, Marco Ruggiero · 2016 · American Journal of Immunology
Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats
Mahmoud E Habieb, Marwa Abd El Hameed Mohamed, Doaa M. El Gamal, Asrar M. Hawas, Tarek Mostafa Mohamed · 2020 · Archives of Gerontology and Geriatrics
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway
Yao Liu, Yuanhuan Wei, Lanlan Wu, Xiaoping Lin, Ruifang Sun, Hengying Chen, Siwen Shen, Guifang Deng · 2022 · Frontiers in Nutrition
Very Low-Carbohydrate High-Fat Diet Improves Risk Markers for Cardiometabolic Health More Than Exercise in Men and Women With Overfat Constitution: Secondary Analysis of a Randomized Controlled Clinical Trial
Lukáš Cipryan, Martina Litschmannová, Philip B. Maffetone, Daniel J. Plews, Tomas Dostal, Peter Hofmann, Paul B. Laursen · 2022 · Frontiers in Nutrition
Understanding How Heart Metabolic Derangement Shows Differential Stage Specificity for Heart Failure with Preserved and Reduced Ejection Fraction
Federico Ferro, Renza Spelat, Camilla Valente, Paolo Contessotto · 2022 · Biomolecules
Mechanisms of NLRP3 activation and pathology during neurodegeneration
Sara Jose, Natalie J. Groves, Kathrein E. Roper, Richard Gordon · 2022 · The International Journal of Biochemistry & Cell Biology
The road ahead of dietary restriction on anti-aging: focusing on personalized nutrition
Hui Duan, Jinwei Li, Leilei Yu, Liuping Fan · 2022 · Critical Reviews in Food Science and Nutrition
Dietary Risk Factors and Eating Behaviors in Peripheral Arterial Disease (PAD)
Andrea Leonardo Cecchini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Giovanni Pecorini, Luis H. Eraso, Paul J DiMuzio, Antonio Gasbarrini, Massimo Massetti, Andrea Flex · 2022 · International Journal of Molecular Sciences
Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease
Daniel S. Whittaker, Katherine T. Tamai, Raj S. Bains, Sophia Anne Marie B Villanueva, Shu Hon Christopher Luk, Derek Dell’Angelica, Gene D. Block, Cristina Antonella Ghiani, Christopher Scott Colwell · 2022 · Frontiers in Nutrition
Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics
Mélanie Bourgin, Sylvère Durand, Guido Kroemer · 2023 · Metabolites
Ketogenic diet alleviates renal fibrosis in mice by enhancing fatty acid oxidation through the free fatty acid receptor 3 pathway
Yang Qiu, Xiao-Fan Hu, Cong Xu, Chenqi Lu, Rui Cao, Yanan Xie, Jun Yang · 2023 · Frontiers in Nutrition
Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis
Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Hemanth Kumar Kandikattu, Lokanatha Oruganti, Chandrasekhar Kathera, Anil Mishra · 2023 · Communications Biology
Elevated Plasma Levels of Ketone Bodies Are Associated With All‐Cause Mortality and Incidence of Heart Failure in Older Adults: The CHS
Sebastian Niezen, Margery A. Connelly, Calvin H. Hirsch, Jorge R. Kizer, María Rodríguez Benítez, Scott Brian Minchenberg, Maria Camila Pérez-Matos, Zhenghui Gordon Jiang, Kenneth Jay Mukamal · 2023 · Journal of the American Heart Association
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Wiramon Rungratanawanich, Jacob W. Ballway, Xin Wang, Kyoung‐Jae Won, James P. Hardwick, Byoung‐Joon Song · 2023 · Pharmacology & Therapeutics
Role of NLRP3 Inflammasome in Stroke Pathobiology: Current Therapeutic Avenues and Future Perspective
Kartik Panbhare, Rukmani Pandey, Chandan Chauhan, Antarip Sinha, Rahul Shukla, Ravinder Kumar Kaundal · 2023 · ACS Chemical Neuroscience
β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis
Ruixue Tian, Shuqin Tang, Jingyu Zhao, Yajie Hao, Limei Zhao, Xiutao Han, Xingru Wang, Lijun Zhang, Rongshan Li, Xiaoshuang Zhou · 2024 · Renal Failure
The level of physical training modulates cytokine levels through P2X7 receptor in healthy subjects
Mario Comassi, Eleonora Santini, Chiara Rossi, Edoardo Vitolo, Marta Seghieri, Leonardo Tocchini, Ferdinando Franzoni, Anna Solini · 2017 · European Journal of Clinical Investigation
Diet starch concentration and starch fermentability affect markers of inflammatory response and oxidant status in dairy cows during the early postpartum period
Rodrigo I. Albornoz, Lorraine M. Sordillo, Genaro Andres Contreras, Rahul K. Nelli, Laman K. Mamedova, B.J. Bradford, Michael S. Allen · 2019 · Journal of Dairy Science