The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Yun-Hee, Nguyen, Kim Y, Grant, Ryan W, Goldberg, Emily L, Bodogai, Monica, Kim, Dongin, D'Agostino, Dominic, Planavsky, Noah +9 more·2015·Nature Medicine
DOI 10.1038/nm.3804
Cited by (1,001)
Items 501–600 of 1,001
- Ketone Metabolite β-Hydroxybutyrate Ameliorates Inflammation After Spinal Cord Injury by Inhibiting the NLRP3 InflammasomeGanggang Kong, Junhao Liu, Rong Li, Junyu Lin, Zucheng Huang, Yang Zhou, Xiuhua Wu, Zhiping Huang, Qingan Zhu, Xiaoliang Wu · 2020 · Neurochemical Research
- Reviewing the importance of TLR‐NLRP3‐pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitorsManas Kinra, Madhavan Nampoothiri, Devinder S Arora, Jayesh Mudgal · 2021 · Scandinavian Journal of Immunology
- Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative DiseasesSubhashini Brahadeeswaran, Narmadhaa Sivagurunathan, Calivarathan Latchoumycandane · 2022 · Molecular Neurobiology
- Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategiesGengzhen Huang, Yaodan Zhang, Yingying Zhang, Yue‐Rong Ma · 2022 · Biochemistry and Biophysics Reports
- Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomersQing-Yun Cheng, Jun Xiong, Fang Wang, Bi‐Feng Yuan, Yu‐Qi Feng · 2017 · Chinese Chemical Letters
- Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activationXianjun Yu, Qun Zhao, Xixi Zhang, Haiwei Zhang, Yongbo Liu, Xiaoxia Wu, Ming Li, Xiaoming Li, Jingxuan Zhang, Xuzhi Ruan et al. · 2017 · Oncotarget
- 14-Day Ketone Supplementation Lowers Glucose and Improves Vascular Function in Obesity: A Randomized Crossover TrialJeremy James Walsh, Helena Neudorf, Jonathan P. Little · 2020 · The Journal of Clinical Endocrinology & Metabolism
- Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceSeungjin Ryu, Irina Shchukina, Yun‐Hee Youm, Hua Qing, Brandon K. Hilliard, Tamara Dlugos, Xinbo Zhang, Yuki Yasumoto, Carmen Jane Booth, Carlos F Fernandez-Hernando et al. · 2021 · eLife
- NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitorsYi Xu, Yanling Yang, Xi Chen, Danling Jiang, Fei Zhang, Yao Guo, Bin Hu, Guohai Xu, Shengliang Peng, Lidong Wu et al. · 2023 · Translational Neurodegeneration
- The effect of a ketogenic diet on inflammation-related markers: a systematic review and meta-analysis of randomized controlled trialsJiawei Ji, Danial Fotros, Mohammad Hassan Sohouli, Periyannan Velu, Somaye Fatahi, Yinghao Liu · 2023 · Nutrition Reviews
- Invited review: Ketone biology—The shifting paradigm of ketones and ketosis in the dairy cowJorge Eduardo Rico, Mario A. Barrientos-Blanco · 2024 · Journal of Dairy Science
- Regulation of Nlrp3 inflammasome by dietary metabolitesChristina D. Camell, Emily L. Goldberg, Vishwa Deep Dixit · 2015 · Seminars in Immunology
- Reduced dynamic range of antiviral innate immune responses in agingRyan D. Molony, Anna Malawista, Ruth R. Montgomery · 2017 · Experimental Gerontology
- Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An UpdateQingying Yu, Tingting Zhao, Molin Liu, Duo Cao, Jiaxin Li, Yanling Li, Mengyao Xia, Xiaoyu Wang, Tingting Zheng, Chuanguo Liu et al. · 2021 · Frontiers in Pharmacology
- Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasomeWeiwei Zhang, Wusan Wang, Chaozhuang Shen, Xiaohu Wang, Zhichen Pu, Qin Yin · 2021 · Aging
- Ketogenic Diet for Cancer: Critical Assessment and Research RecommendationsJordin Lane, Nashira I. Brown, Shanquela Williams, Eric P. Plaisance, Kevin R. Fontaine · 2021 · Nutrients
- Ketone Body β ‐Hydroxybutyrate Prevents Myocardial Oxidative Stress in Septic CardiomyopathyLiwei Ji, Qinqin He, Yinghai Liu, Yan Deng, Maodi Xie, Kaiteng Luo, Xintian Cai, Yunxia Zuo, Wei Wu, Qian Li et al. · 2022 · Oxidative Medicine and Cellular Longevity
- The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophyYukun Liu, Dongfang Wang, Tianyu Li, Fan Yang, Zhanfei Li, Xiangjun Bai, Yu-Chang Wang · 2022 · Frontiers in Immunology
- Is There a Role for Diet in the Therapy of Rheumatoid Arthritis?Sara K. Tedeschi, Karen H. Costenbader · 2016 · Current Rheumatology Reports
- Exploring the Feasibility and Effects of a Ketogenic Diet in Patients With CNS Malignancies: A Retrospective Case SeriesCristina M. Panhans, Gillian K. Gresham, L J Amaral, Jethro Lisien Hu · 2020 · Frontiers in Neuroscience
- Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease ModelsBiswadeep Das, Chayna Sarkar, Vikram Singh Rawat, Deepjyoti Kalita, Sangeeta Deka, Akash Agnihotri · 2021 · Molecules
- Directly targeting ASC by lonidamine alleviates inflammasome-driven diseasesChen Chen, Yuwei Zhou, XinPeng Ning, ShengLong Li, Dongdong Xue, CaiLv Wei, Zhu Zhu, Longxiang Sheng, Bingzheng Lu, Yuan Li et al. · 2022 · Journal of Neuroinflammation
- Common and divergent molecular mechanisms of fasting and ketogenic dietsAntonio Paoli, Grant M. Tinsley, Mark P. Mattson, Immaculata De Vivo, Ravi Dhawan, Tatiana Moro · 2023 · Trends in Endocrinology and Metabolism
- Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart FailureTobias de la Garza Eckle, Júlia Bertazzo, Tarak Nath Khatua, Seyed Reza Fatemi Tabatabaei, Naghmeh Moori Bakhtiari, Lori A. Walker, Tami A. Martino · 2024 · Circulation Research
- Microbiome in radiotherapy: an emerging approach to enhance treatment efficacy and reduce tissue injuryLina Lu, Fengxiao Li, Yuanyuan Gao, Shuhe Kang, Jia Li, Jinwang Guo · 2024 · Molecular Medicine
- Ketone body 3‐hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retinaYusuke Izuta, Toshihiro Imada, Ryuji Hisamura, Erina Oonishi, Shigeru Nakamura, Emi Inagaki, Masataka Ito, Tomoyoshi Soga, Kazuo Tsubota · 2017 · Aging Cell
- Microglial Immunometabolism in Alzheimer’s DiseaseDaniel C. Shippy, Tyler Kent Ulland · 2020 · Frontiers in Cellular Neuroscience
- Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosisLi Gao, Jie‐Xing Qin, Jian‐Quan Shi, Teng Jiang, Fei Wang, Chong Xie, Qing Gao, Nan Zhi, Qing Dong, Yangtai Guan · 2022 · CNS Neuroscience & Therapeutics
- The relationship between d ‐beta‐hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsyJeffrey Buchhalter, Sabrina D’Alfonso, Mary B. Connolly, Ernest Fung, Aspasia Michoulas, David S. Sinasac, Rachel Singer, Jacklyn D. Smith, Narender Singh, Jong M. Rho · 2017 · Epilepsia Open
- Activating α7 nicotinic acetylcholine receptor inhibits NLRP 3 inflammasome through regulation of β‐arrestin‐1Ping Ke, Bo‐Zong Shao, Zhe‐Qi Xu, Xiongwen Chen, Wei Wei, Chong Liu · 2017 · CNS Neuroscience & Therapeutics
- The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infectionSoroush T. Sarvestani, Julie McAuley · 2017 · Antiviral Research
- Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticusRavindra Arya, Katrina Peariso, Marina Gaínza‐Lein, Jessica Harvey, Ann Marie R. Bergin, James Nicholas Brenton, Brian T. Burrows, Tracy A. Glauser, Howard P. Goodkin, Yi‐Chen Lai et al. · 2018 · Epilepsy Research
- Ketone therapy for heart failure: current evidence for clinical useShingo Takahara, Shubham Soni, Zaid H. Maayah, Mourad Ferdaoussi, Jason R.B. Dyck · 2021 · Cardiovascular Research
- An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related ProcessesAroa Baragaño Raneros, Cristian Ruiz Bernet, Aida Bernardo Flórez, Beatriz Suárez-Álvarez · 2021 · Biomedicines
- Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosisHarsh Vardhan Charan, Durgesh Kumar Dwivedi, Sabbir Khan, Gopabandhu Jena · 2022 · Genes & Diseases
- Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic CardiomyopathyZhengyao Cai, Suxin Yuan, Xingzhao Luan, Jian Feng, Li Deng, Yumei Zuo, Jiafu Li · 2022 · Frontiers in Pharmacology
- The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiationYanglin Wu, Yun Teng, Chenhui Zhang, Ying H. Pan, Qin Zhang, Xu Hui Zhu, Naicheng Liu, Xinlin Su, Jun Lin · 2022 · Journal of Nanobiotechnology
- Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcificationZirong Lan, An Chen, Li Li, Yuanzhi Ye, Qingchun Liang, Qianqian Dong, Siyi Wang, Mingwei Fu, Yining Li, Xiaoyu Liu et al. · 2022 · The Journal of Pathology
- β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stressShilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu et al. · 2022 · International Immunopharmacology
- A ketogenic diet substantially reshapes the human metabolomeDavid Effinger, Simon Hirschberger, Polina Yoncheva, Annika Schmid, Till Heine, Patrick Newels, Burkhard Schütz, Chen Meng, Michael Gigl, Karin Kleigrewe et al. · 2023 · Clinical Nutrition
- Research advances in the anti-inflammatory effects of SGLT inhibitors in type 2 diabetes mellitusRuining Zhang, Qingxing Xie, Xi Lu, Rongping Fan, Nanwei Tong · 2024 · Diabetology & Metabolic Syndrome
- Inhibition of monoacylglycerol lipase terminates diazepam‐resistant status epilepticus in mice and its effects are potentiated by a ketogenic dietGaetano Terrone, Alberto Pauletti, Alessia Salamone, Massimo Rizzi, Bianca R. Villa, Luca Porcu, Mark J. Sheehan, Edward R. Guilmette, Christopher R. Butler, Justin R. Piro et al. · 2017 · Epilepsia
- Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotraumaAlexandra Bernardo‐Colón, Victoria D. Vest, Adrienne Clark, Melissa Cooper, David John Calkins, Fiona Edith Harrison, Tonia S. Rex · 2018 · Cell Death and Disease
- Molecular Mechanisms Underlying the Bioactive Properties of a Ketogenic DietMari Murakami, Paola Tognini · 2022 · Nutrients
- Targeting inflammatory signaling pathways with SGLT2 inhibitors: Insights into cardiovascular health and cardiac cell improvementFatmah R. Alsereidi, Zenith Khashim, Hezlin Marzook, Anamika Gupta, Ahmed M. Al-Rawi, Mahmoud Mohammed Ramadan, Mohamed A. Saleh · 2024 · Current Problems in Cardiology
- β‐Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2 / AMPK / PINK1 /Parkin pathwayHuangming Zhuang, Xunshan Ren, Yuelong Zhang, Huajie Li, Panghu Zhou · 2024 · Aging Cell
- Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future ProspectsYoav Gal, Ohad Mazor, Reut Falach, Anita Sapoznikov, Chanoch Kronman, Tamar Sabo · 2017 · Toxins
- Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human MonocytesHelena Neudorf, Cody Garett Durrer, Étienne Myette‐Côté, Caitlyn Makins, Trevor O’Malley, Jonathan P. Little · 2019 · Molecular Nutrition & Food Research
- Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicineGaosong Wu, Hou-Kai Li, Weidong Zhang · 2019 · Chinese Journal of Natural Medicines
- Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation ConceptDae Hyun Kim, EunJin Bang, Hee Jin Jung, Sang Gyun Noh, Byung Pal Yu, Yeon Ja Choi, Hae Young Chung · 2020 · Nutrients
- β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal MuscleParker, Brian A., Walton, Chase M., Carr, Sheryl T., Andrus, Jacob L., Cheung, Eric C. K., Duplisea, Michael J., Wilson, Esther K., Draney, Carrie, Lathen, Daniel R., Kenner, Kyle B. et al. · 2018 · International Journal of Molecular Sciences
- Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitisLi Zhang, Juanjuan Shi, Dan Du, Ningning Niu, Shiyu Liu, Xiaotong Yang, Ping Lu, Xuqing Shen, Na Shi, Linbo Yao et al. · 2022 · EBioMedicine
- The ketone body β‐hydroxybutyrate shifts microglial metabolism and suppresses amyloid‐β oligomer‐induced inflammation in human microgliaLee‐Way Jin, Jacopo Di Lucente, Ulises Ruiz Mendiola, Nopparat Suthprasertporn, Alexey A. Tomilov, Gino A. Cortopassi, Kyoungmi Kim, Jon Jay Ramsey, Izumi Maezawa · 2023 · The FASEB Journal
- Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7Xiangyu Jin, Didi Liu, Xinru Zhou, Xianyu Luo, Qian Huang, Yi Huang · 2023 · Cell Reports Medicine
- Intermittent fasting and longevity: From animal models to implication for humansOlha M. Strilbytska, Svitlana Klishch, Kenneth B. Storey, Alexander K. Koliada, Oleh V. Lushchak · 2024 · Ageing Research Reviews
- A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunityMargaret Alexander, Vaibhav Upadhyay, Rachel Rock, Lorenzo Ramirez, Kai R. Trepka, Patrycja Puchalska, Diego A. Orellana, Qi Yan Ang, Caroline Whitty, Jessie A. Turnbaugh et al. · 2024 · Cell Reports
- Five Days Periodic Fasting Elevates Levels of Longevity Related Christensenella and Sirtuin Expression in HumansStephanie Lilja, Carina Stoll, Ulrike D. B. Krammer, Berit Hippe, Kalina Duszka, Tewodros Debebe, Ingrid Höfinger, Jürgen S. König, Angelika Pointner, Alexander G. Haslberger · 2021 · International Journal of Molecular Sciences
- MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese MiceMenglong Wang, Mengmeng Zhao, Junping Yu, Yao Qun Xu, Jishou Zhang, Jianfang Liu, Zihui Zheng, Jing Ye, Zhen Wang, Di Ye et al. · 2022 · Frontiers in Cardiovascular Medicine
- The Evolution of Ketosis: Potential Impact on Clinical ConditionsLatha Nagamani Dilliraj, Giovanna Schiuma, Djidjell Lara, Giovanni Strazzabosco, James Clement, Pier Paolo Giovannini, Claudio Trapella, Marco Narducci, Roberta Rizzo · 2022 · Nutrients
- What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome researchAbhinit Nagar, Ravi Bharadwaj, Mohammad Omar Faruk Shaikh, Abhishek Ghosh Roy · 2023 · Frontiers in Immunology
- Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitorsYe Tao, Weiyan Tao, Xiao-yi Chen, Cheng Jiang, Bin Di, Lili Xu · 2023 · Cytokine & Growth Factor Reviews
- Diabetes Mellitus, Energy Metabolism, and COVID-19Caterina Conte, Elisa Cipponeri, Michael Roden · 2023 · Endocrine Reviews
- The Interplay Between Immunity, Inflammation and Endothelial DysfunctionYing Jie Chee, Rinkoo Dalan, Christine Cheung · 2025 · International Journal of Molecular Sciences
- Gain of function mutation and inflammasome driven diseases in human and mouse modelsMario David Cordero, Elísabet Alcocer‐Gómez, Bernhard Ryffel · 2018 · Journal of Autoimmunity
- Keto-Adaptation and Endurance Exercise Capacity, Fatigue Recovery, and Exercise-Induced Muscle and Organ Damage Prevention: A Narrative ReviewSihui Ma, Katsuhiko Suzuki · 2019 · Sports
- Reinterpreting Cardiorenal Protection of Renal Sodium–Glucose Cotransporter 2 Inhibitors via Cellular Life History ProgrammingAngelo Avogaro, Gian Paolo Fadini, Stefano Del Prato · 2019 · Diabetes Care
- Pharmacotherapy for Pediatric Convulsive Status EpilepticusAvantika Singh, Coral M. Stredny, Tobias Loddenkemper · 2019 · CNS Drugs
- The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogenic diet?Antonio Paoli, Stefania Gorini, Massimiliano Caprio · 2020 · Journal of Translational Medicine
- Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder modelTakehiko Yamanashi, Masaaki Iwata, Midori Shibushita, Kyohei Tsunetomi, Mayu Nagata, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Takahiro A. Kato et al. · 2020 · Scientific Reports
- Sinapic Acid Controls Inflammation by Suppressing NLRP3 Inflammasome ActivationEun Hye Lee, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo · 2021 · Cells
- Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced MiceQing Liu, Manman Zhang, Min-Xia Guo, Qiuping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang‐Hui Xu, Cheng‐Fu Li, Ji‐Xiao Zhu et al. · 2022 · Journal of Neuroimmune Pharmacology
- Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunitiesMiguel Angel Ortega, Diego De León-Oliva, Cielo García Montero, Oscar Fraile‐Μartinez, Diego Liviu Boaru, Amador Velazquez de Castro, Miguel A. Sáez, Laura López-González, Julia Buján, Miguel Ángel Álvarez-Mon et al. · 2023 · Frontiers in Immunology
- Lipid and glucose metabolism in senescenceBin Liu, Qingfei Meng, Xin Gao, Huihui Sun, Zhi–Xiang Xu, Yishu Wang, Honglan Zhou · 2023 · Frontiers in Nutrition
- Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitorsMona Mashayekhi, Bilgunay Ilkin Safa, Matthew S.C. Gonzalez, Sangwon F. Kim, Justin Basile Echouffo-Tcheugui · 2024 · Trends in Endocrinology and Metabolism
- Metabotyping reveals distinct metabolic alterations in ketotic cows and identifies early predictive serum biomarkers for the risk of diseaseGuanshi Zhang, Elda Dervishi, Suzanna M. Dunn, Rupasri Mandal, Philip Liu, Beomsoo Han, David Scott Wishart, Burim Namik Ametaj · 2017 · Metabolomics
- Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetesSe Hee Min, Tae Jung Oh, Seunghwan Baek, D.-H. Lee, K.M. Kim, Joon Ho Moon, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Kyung Lim · 2017 · Diabetes & Metabolism
- Neopterin preconditioning prevents inflammasome activation in mammalian astrocytesRoberta de Paula Martins, Karina Ghisoni, Chai K. Lim, Aderbal S. Aguiar, Gilles J. Guillemin, Alexandra Latini · 2017 · Free Radical Biology and Medicine
- Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecanYi-qiao Gao, Wei Li, Jiaqing Chen, Xu Wang, Yingtong Lv, Yin Huang, Zun-Jian Zhang, Feng-Guo Xu · 2018 · Acta Pharmaceutica Sinica B
- Therapeutic alternative of the ketogenic Mediterranean diet to improve mitochondrial activity in Amyotrophic Lateral Sclerosis (ALS): A Comprehensive ReviewJordi Caplliure‐Llopis, Thalía Peralta Chamba, Sandra Carrera‐Juliá, María Cuerda‐Ballester, Eraci Drehmer, María Mar López‐Rodriguez, José Enrique de la Rubia Ortí · 2019 · Food Science & Nutrition
- Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefitAstrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo Garcia Guerra, Sascha C. A. T. Verbruggen, Koen Joosten, Lies Langouche, Greet Van den Berghe · 2020 · Critical Care
- Rational Application of β-Hydroxybutyrate Attenuates Ischemic Stroke by Suppressing Oxidative Stress and Mitochondrial-Dependent Apoptosis via Activation of the Erk/CREB/eNOS PathwayYang Li, Xuepeng Zhang, Aijia Ma, Yan Ming Kang · 2021 · ACS Chemical Neuroscience
- Therapeutic Role of Inflammasome Inhibitors in Neurodegenerative DisordersLahooti, Behnaz, Chhibber, Tanya, Bagchi, Sounak, Varahachalam, Sree Pooja, Jayant, Rahul D. · 2021 · Brain, Behavior, and Immunity
- Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depressionKajitani, Naofumi, Iwata, Masaaki, Miura, Akihiko, Tsunetomi, Kyohei, Yamanashi, Takehiko, Matsuo, Ryoichi, Nishiguchi, Tsuyoshi, Fukuda, Saki, Nagata, Mayu, Shibushita, Midori et al. · 2020 · Neuropsychopharmacology Reports
- Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritisRekha Narasimhan, Roxana Coras, Sara Brin Rosenthal, Shannon Sweeney, Alessia Lodi, Stefano Tiziani, David Boyle, Arthur Kavanaugh, Mónica Gumá · 2018 · Arthritis Research & Therapy
- Beta-Hydroxybutyrate, Friend or Foe for Stressed HeartsYuxin Chu, Cheng Zhang, Min Xie · 2021 · Frontiers in Aging
- Applications of Ketogenic Diets in Patients with Headache: Clinical RecommendationsCherubino Di Lorenzo, Giovanna Ballerini, Piero Barbanti, Andrea Bernardini, Giacomo D’Arrigo, Gabriella Egeo, Fabio Frediani, Riccardo Garbo, Giulia Pierangeli, Maria Pia Prudenzano et al. · 2021 · Nutrients
- Updates on the ketogenic diet therapy for pediatric epilepsyAra Ko, Hye Eun Kwon, Heung Dong Kim · 2021 · Biomedical Journal
- Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injuryMeng Song, Zijun Chen, Ruian Qiu, Tingwei Zhi, Wenmin Xie, Yingya Zhou, Nachuan Luo, Fuqian Chen, Fang Liu, Chuangpeng Shen et al. · 2022 · Redox Biology
- Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase StimulationLaura R. Hoyt, Jennifer L. Ather, Matthew J. Randall, Daniel P. DePuccio, Christopher C. Landry, Mark Damian Wewers, Mikhail A. Gavrilin, Matthew E. Poynter · 2016 · The Journal of Immunology
- Bone marrow-derived naïve B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozinYue Xu, Kai Jiang, Feng Chen, Jie Qian, Dandan Wang, Yizhang Wu, Chunjiang Zhou, Yong Yu, Kun Chen, John Hwa et al. · 2022 · Basic Research in Cardiology
- NLRP3: a new therapeutic target in alcoholic liver diseaseSubhashini Brahadeeswaran, Tiasha Dasgupta, Venkatraman Manickam, Viswanathan Saraswathi, Ramasamy Tamizhselvi · 2023 · Frontiers in Immunology
- Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's diseaseAna Isabel Duarte, Maria S. Santos, Catarina Resende Oliveira, Paula Isabel Moreira · 2018 · Neuropharmacology
- 2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure ControlJong M. Rho, Li-Rong Shao, Carl E. Stafstrom · 2019 · Frontiers in Cellular Neuroscience
- NMR-based metabolomics in real-time monitoring of treatment induced toxicity and cachexia in head and neck cancer: a method for early detection of high risk patientsŁukasz Boguszewicz, Agata Bieleń, Jolanta Mrochem‐Kwarciak, Agnieszka Skorupa, Mateusz Ciszek, Alicja Heyda, A. Wygoda, Anna Kotylak, Krzysztof Składowski, Maria B. Sokol · 2019 · Metabolomics
- Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorderRahul Kewal Kumar, T Amruthanjali, Siva Singothu, Shashi Bala Singh, Vasundhra Bhandari · 2022 · Biomedicine & Pharmacotherapy
- The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liverShailee Jani, Daniel Da Eira, Mateja Stefanovic, Rolando Bacis Ceddia · 2022 · The Journal of Physiology
- Dietary Interventions in Cancer Treatment and Response: A Comprehensive ReviewBenjamin D. Mercier, Eemon Tizpa, Errol James Philip, Qianhua Feng, Ziyi Huang, Reeny M. Thomas, Sumanta Kumar Pal, Tanya Barauskas Dorff, Yun R. Li · 2022 · Cancers
- The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki diseaseFangyan Wang, Fanyu Qian, Qihao Zhang, Jian Zhao, Jianke Cen, Jiamin Zhang, Jinhui Zhou, Ming Luo, Chang Jia, Xing Rong et al. · 2023 · Frontiers in Immunology
- Impact of fasting & ketogenic interventions on the NLRP3 inflammasome: A narrative reviewHelena Neudorf, Jonathan P. Little · 2023 · Biomedical Journal
- β-Hydroxybutyrate suppresses M1 macrophage polarization through β-hydroxybutyrylation of the STAT1 proteinYa-Ping Bai, Yujie Xing, Tao Ma, Kai Li, Teng Zhang, De-Guo Wang, Shujun Wan, Cui-Wei Zhang, Yue Sun, Meng‐Yan Wang et al. · 2024 · Cell Death and Disease