The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Yun-Hee, Nguyen, Kim Y, Grant, Ryan W, Goldberg, Emily L, Bodogai, Monica, Kim, Dongin, D'Agostino, Dominic, Planavsky, Noah +9 more·2015·Nature Medicine

DOI 10.1038/nm.3804

Cited by (1,001)

Items 801–900 of 1,001

Fabry Disease: Cardiac Implications and Molecular Mechanisms
David Weissman, Jan Dudek, Vasco Sequeira, Christoph Maack · 2024 · Current Heart Failure Reports
NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development
Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou, Mukut Sharma, Ram Sharma, Vikas Singh · 2024 · International Journal of Molecular Sciences
Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages
Jiayi Mao, Wenzheng Xia, Yanglin Wu, Minxiong Li, Yun Zhao, Peisong Zhai, Yuguang Zhang, Tao Zan, Wenguo Cui, Xiaoming Sun · 2024 · Research
Cardioprotective Roles of β-Hydroxybutyrate Against Doxorubicin Induced Cardiotoxicity
Yihai Liu, Xuan Wei, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang · 2021 · Frontiers in Pharmacology
Emerging Roles of Sodium Glucose Cotransporter 2 (SGLT-2) Inhibitors in Diabetic Cardiovascular Diseases: Focusing on Immunity, Inflammation and Metabolism
Lingxiang Xie, Yang Xiao, Shi Tai, Huijie Yang, Shenghua Zhou, Zhiguang Zhou · 2022 · Frontiers in Pharmacology
Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies
Weili Fu, Minghao Ge, Jian Li · 2023 · Journal of Translational Medicine
Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction
Salva R. Yurista, Robert A. Eder, Aidan Welsh, WILLIAM Y. JIANG, Shi Chen, Anna N. Foster, Adam Mauskapf, W.H. Wilson Tang, William J. Hucker, Jaume Coll‐Font et al. · 2023 · Metabolism
Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC
Jia Zhao, Hongbin Liu, Zhixian Hong, Wenqing Mu, Wenqing Mu, Xiaorong Hou, Guang Xu, 方志娥, Lutong Ren, Tingting Liu et al. · 2023 · Molecular Medicine
Orthosteric and allosteric modulation of human HCAR2 signaling complex
Chunyou Mao, Mengru Gao, Shao‐Kun Zang, Yanqing Zhu, Dandan Shen, Li-Nan Chen, Yang Liu, Zhiwei Wang, Huibing Zhang, Weiwei Wang et al. · 2023 · Nature Communications
A Standard Lipid Panel Is Insufficient for the Care of a Patient on a High-Fat, Low-Carbohydrate Ketogenic Diet
Nicholas G. Norwitz, Vyvyane Loh · 2020 · Frontiers in Medicine
Ketone bodies in cell physiology and cancer
Giacomo Giuliani, Valter Daniel Longo · 2024 · American Journal of Physiology-Cell Physiology
Drug resistant epilepsy and ketogenic diet: A narrative review of mechanisms of action
Priyadarshini Mishra, Sajal Clarence Singh, Balamurugan Ramadass · 2024 · World Neurosurgery X
Therapeutic potential of the ketogenic diet: A metabolic switch with implications for neurological disorders, the gut-brain axis, and cardiovascular diseases
Sheyda Shahpasand, Seyyed Hossein Khatami, Sajad Ehtiati, Parsa Alehossein, Farzaneh Salmani, Alireza Haghbin Toutounchi, Tayebe Zarei, Mohammad Reza Shahmohammadi, Reza Khodarahmi‬, Vajiheh Aghamollaii et al. · 2024 · The Journal of Nutritional Biochemistry
Health Benefits of Intermittent Fasting
B Lakshmi Reddy, Vamsee S. Reddy, Milton H. Saier · 2024 · Microbial Physiology
Intermittent fasting, fatty acid metabolism reprogramming, and neuroimmuno microenvironment: mechanisms and application prospects
Anren Zhang, Junyu Wang, Yinuo Zhao, Yu He, Nianyi Sun · 2024 · Frontiers in Nutrition
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Sidharth S. Madhavan, Stephanie Roa Diaz, Sawyer Peralta, Mitsunori Nomura, Christina D. King, Kaya E. Ceyhan, Anwen Lin, Dipa Bhaumik, Anna Foulger, Samah Shah et al. · 2024 · Cell chemical biology
Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions
Andrea L Cote, Chad J. Munger, Alison Epstein Ringel · 2025 · Cell Reports
Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins
Gala Araujo, Leidy Marian Valencia, Agata Martin-Ozimek, Yosdel Soto, Spencer D. Proctor · 2025 · Frontiers in Immunology
Valeric Acid: A Gut-Derived Metabolite as a Potential Epigenetic Modulator of Neuroinflammation in the Gut–Brain Axis
Chiara Paciolla, Michele Manganelli, Mariagiovanna Di Chiano, Francesca Montenegro, Anna Gallone, Fabio Sallustio, Gabriella Guida · 2025 · Cells
The ageing immune system as a driver of systemic ageing
In Hwa Jang, Laura J. Niedernhofer, Paul D. Robbins, Christina D. Camell · 2026 · Nature reviews. Immunology
Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy
Parker N. Hyde, Maryam B. Lustberg, Vincent J. Miller, Richard A. LaFountain, Jeff S. Volek · 2017 · Cancer Treatment and Research Communications
NLRs as Helpline in the Brain: Mechanisms and Therapeutic Implications
Shalini Singh, Sushmita Jha · 2018 · Molecular Neurobiology
Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice
Jonghae Lee, Yang Lee, Emily C. P. LaVoy, Michihisa Umetani, Junyoung Hong, Yoonjung Park · 2018 · Physiological Reports
Ketogenic and anaplerotic dietary modifications ameliorate seizure activity in Drosophila models of mitochondrial encephalomyopathy and glycolytic enzymopathy
Keri J. Fogle, Amber R. Smith, Sidney L. Satterfield, Alejandra Gutierrez, J. Ian Hertzler, Caleb S. McCardell, Joy H. Shon, Zackery J. Barile, Molly O. Novak, Michael J. Palladino · 2019 · Molecular Genetics and Metabolism
Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice
Charles P. Hinzman, Janet E. Baulch, Khyati Y. Mehta, Michael J. Girgis, Shivani Bansal, Kirandeep Gill, Yaoxiang Li, Charles L. Limoli, Amrita K. Cheema · 2019 · Scientific Reports
New perspective toward nutritional support for malnourished cancer patients: Role of lipids
Yandan Wang, Tao Zhang, Ruijie Liu, Ming Chang, Wei Wei, Qingzhe Jin, Xingguo Wang · 2021 · Comprehensive Reviews in Food Science and Food Safety
Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes
Maria Sebastian-Valverde, Henry D. Wu, Md Al Rahim, Roberto Sánchez, Kunal Kumar, Robert J. De Vita, Giulio Maria Pasinetti · 2021 · Journal of Biological Chemistry
The Therapeutic Potential and Limitations of Ketones in Traumatic Brain Injury
Savannah Anne Daines · 2021 · Frontiers in Neurology
The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis
Yue Hu, Min Zhao, Tong Tao Zhao, Mingming Qi, Guangda Yao, Yu Juan Dong · 2022 · Frontiers in Pharmacology
Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver
Pimsiri Sripongpun, Chaitong Churuangsuk, Chalermrat Bunchorntavakul · 2022 · Journal of Clinical and Translational Hepatology
The role of cuproptosis-related gene in the classification and prognosis of melanoma
Jin-Ya Liu, Le-Ping Liu, Ze Li, Yanwei Luo, Fang Liang · 2022 · Frontiers in Immunology
Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC
Wen Liu, Jia‐Shu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Ren Xiang Tan, Qiang Xu, Wenjie Guo · 2022 · Journal of Biological Chemistry
Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation
Emily L. Goldberg, Anudari Letian, Tamara Dlugos, Claire Leveau, Vishwa Deep Dixit · 2023 · Journal of Biological Chemistry
The Ketogenic Diet in Colorectal Cancer: A Means to an End
Magie Tamraz, Najib Al Ghossaini, Sally Naji Temraz · 2023 · International Journal of Molecular Sciences
Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social defeat
González Ibáñez, Fernando, Halvorson, Torin, Sharma, Kaushik, McKee, Chloe Grace, Carrier, Micaël, Picard, Katherine, Vernoux, Nathalie, Bisht, Kanchan, Deslauriers, Jessica, Lalowski, Maciej et al. · 2023 · Brain, Behavior, and Immunity
Liver X receptors agonists suppress NLRP3 inflammasome activation
Shui-Xing Yu, Wei Chen, Xiao-Zhu Hu, Shiyuan Feng, Kun-Yu Li, Shuai Qi, Qian-Qian Lei, Guiqiu Hu, Ning Li, Fenghua Zhou et al. · 2016 · Cytokine
Emerging role of metabolomics in rheumatology
Latika Gupta, Sakir Ahmed, Avinash Jain, Ramnath Misra · 2018 · International Journal of Rheumatic Diseases
Neuroprotective effects of a ketogenic diet in combination with exogenous ketone salts following acute spinal cord injury
Botao Tan, Hui Jiang, Aaron J. Moulson, Xiaoliang Wu, Wenchun Wang, Jie Liu, Ward T. Plunet, Wolfram Tetzlaff · 2020 · Neural Regeneration Research
Non-Canonical Inflammasome Pathway: The Role of Cell Death and Inflammation in Ehrlichiosis
Aditya Kumar Sharma, Nahed Ismail · 2023 · Cells
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease
Daniel C. Shippy, Abigail H. Evered, Tyler Kent Ulland · 2024 · Immunological Reviews
Ketone body metabolism and cardiometabolic implications for cognitive health
Kyle Fulghum, Sebastian F. Salathe, Xin C. Davis, John P. Thyfault, Patrycja Puchalska, Peter A. Crawford · 2024 · npj Metabolic Health and Disease
Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation
Queathem, Eric D., Moazzami, Zahra, Stagg, David B., Nelson, Alisa B., Fulghum, Kyle, Hayir, Abdirahman, Seay, Alisha, Gillingham, Jacob R., d’Avignon, D. André, Han, Xianlin et al. · 2025 · Science Advances
Reversible histone deacetylase activity catalyzes lysine acylation
Takeshi Tsusaka, Mohd Altaf Najar, Benjamin H. Schwarz, Eric Bohrnsen, Juan A. Osés-Prieto, Helena Neudorf, Christina Lee, Jonathan P. Little, Alma L. Burlingame, Catharine M. Bosio et al. · 2025 · Nature Chemical Biology
Bushen‐Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson’s Disease
Yousheng Mo, Erjin Xu, Renrong Wei, Baoluu Le, Lei Song, Dongli Li, Yonggen Chen, Xiaotian Ji, Shuhuan Fang, Jiangang Shen et al. · 2018 · Evidence-based Complementary and Alternative Medicine
Systems Thinking About SARS-CoV-2
Rainer J. Klement · 2020 · Frontiers in Public Health
Anticonvulsant mechanisms of the ketogenic diet and caloric restriction
Rudy Luna, Carmen Rubio, Daniel Rojas, Rosiles Artemio, Moisés Rubio‐Osornio · 2020 · Epilepsy Research
Transcriptional response of murine microglia in Alzheimer’s disease and inflammation
Daniel C. Shippy, Jyoti J. Watters, Tyler Kent Ulland · 2022 · BMC Genomics
Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels
Zhou Xu, Mingyue Zhang, Xinran Li, Yong Wang, Ronghui Du · 2022 · International Journal of Molecular Sciences
Alternate‐Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver
Yanjie Guo, Xiaoxie Liu, Tao Li, Juanhua Zhao, Yanni Yang, Yanni Yao, Lan Wang, Beibei Yang, Gui Ren, Yanzhen Tan et al. · 2022 · Oxidative Medicine and Cellular Longevity
Role of Ketogenic Diets in Multiple Sclerosis and Related Animal Models: An Updated Review
Wei‐Sheng Lin, Shan-Ju Lin, Pei-Yin Liao, Divya Suresh, Ting‐Rong Hsu, Pei‐Yu Wang · 2022 · Advances in Nutrition
A natural extracellular matrix hydrogel through selective nutrient restriction for hyperinflammatory starvation therapy
Pengfei Chen, Kaifeng Pan, Nan Song, Yang Yang, Chenhui Gu, Peiyu Zhong, Lin Li, Mobai Li, Ying Zhang, Zhanqiu Dai et al. · 2022 · Matter
The therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle
Shubham Soni, Seyed Amirhossein Tabatabaei Dakhili, John R. Ussher, Jason R.B. Dyck · 2024 · American Journal of Physiology-Cell Physiology
Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill patients with diabetes: an observational study
Nora Luethi, Luca Cioccari, Marco Crisman, Rinaldo Bellomo, Glenn M. Eastwood, Johan Mårtensson · 2016 · Critical Care
The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model
Anne L. Slaughter, Geoffrey R. Nunns, Angelo D’Alessandro, Anirban M. Banerjee, Kirk Charles Hansen, Ernest Eugene Moore, Christopher C. Silliman, Travis G. Nemkov, Hunter B. Moore, Miguel Fragoso et al. · 2017 · Shock
Salmeterol, agonist of β2-aderenergic receptor, prevents systemic inflammation via inhibiting NLRP3 inflammasome
Nanshan Song, Yinquan Fang, Xiyang Sun, Qingling Jiang, Chenghuan Song, Miaomiao Chen, Jianhua Ding, Ming Lu, Gang Hu · 2018 · Biochemical Pharmacology
Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics
Chase M. Walton, Samuel M. Jacobsen, Blake W. Dallon, Erin R. Saito, Shantelle L. H. Bennett, Lance E. Davidson, David M. Thomson, Robert D. Hyldahl, Benjamin T. Bikman · 2020 · International Journal of Molecular Sciences
Does Glycemic Control Modulate the Impairment of NLRP3 Inflammasome Activation in Type 2 Diabetes?
Francesca Iannantuoni, Noelia Díaz‐Morales, Irene Escribano‐López, Eva Solá, Ildefonso Roldán Torres, Nadezda Apostolova, Celia Bañuls, Susana Rovira‐Llopis, Milagros Rocha, Víctor M. Víctor · 2018 · Antioxidants and Redox Signaling
Effect of Ketogenic Diet on Obesity and Other Metabolic Disorders: Narrative Review
Baylie, Temesgen, Ayelgn, Tiget, Tiruneh, Markeshaw, Tesfa, Kibur · 2024 · Diabetes, Metabolic Syndrome and Obesity
Rethinking weight loss treatments as cardiovascular medicine in obesity, a comprehensive review
Dario Tuccinardi, Mikiko Watanabe, Davide Masi, Lavinia Monte, Luigi Bonifazi Meffe, Ilaria Cavallari, Annunziata Nusca, Ernesto Maddaloni, Lucio Gnessi, Nicola Napoli et al. · 2024 · European Journal of Preventive Cardiology
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells
Philipp Schaible, Julia Henschel, Daniel Erny · 2025 · Journal of Neuroinflammation
The Role of NLRP3 Inflammasome in Type 2 Diabetes Mellitus and Its Macrovascular Complications
Konstantinos Karamitsos, Evangelos Oikonomou, P. Theofilis, I. Ikonomidis, Eva Kassi, Vaia Lambadiari, E. Gialafos, A. Tsatsaragkou, V. Mystakidi, K. Zisimos et al. · 2025 · Journal of Clinical Medicine
NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes
Bhavana Chhunchha, Eri Kubo, Deepali Lehri, Dhirendra P. Singh · 2025 · Cells
Different milk diets have substantial effects on the jejunal mucosal immune system of pre-weaning calves, as demonstrated by whole transcriptome sequencing
Harald Michael Hammon, D. Frieten, C. Gerbert, Christian Koch, G. Dusel, Rosemarie Weikard, C. Kühn · 2018 · Scientific Reports
Progress in Treatment of Gout Using Chinese and Western Medicine
Xiang Wang, Yangang Wang · 2019 · Chinese Journal of Integrative Medicine
Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential
Ma Su, Weiwei Wang, Feng Liu, Huanqiu Li · 2020 · Current Medicinal Chemistry
β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells
Adrián Benito, Nabil Hajji, Kevin O’Neill, Hector C. Keun, Nelofer Syed · 2020 · Metabolites
A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice
Mary P. Moore, Rory P. Cunningham, Rachel A. H. Davis, Sarah E. Deemer, Brandon M. Roberts, Eric P. Plaisance, R. Scott Rector · 2021 · American Journal of Physiology-Gastrointestinal and Liver Physiology
The Ability to Normalise Energy Metabolism in Advanced COVID-19 Disease Seems to Be One of the Key Factors Determining the Disease Progression—A Metabolomic NMR Study on Blood Plasma
Eva Baranovičová, Anna Bobčáková, Róbert Vyšehradský, Zuzana Daňková, Erika Halášová, Vladimír Nosáľ, Ján Lehotský · 2021 · Applied Sciences
β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption
Yoshiki Hirata, Sayaka Shimazaki, Sae Suzuki, Yuka Henmi, Hiromu Komiyama, Takehito Kuwayama, Hisataka Iwata, Tadayoshi Karasawa, Masafumi Takahashi, Hironori Takahashi et al. · 2021 · Journal of Reproductive Immunology
Treatments for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies
Shingo Takada, Hisataka Sabe, Shintaro Kinugawa · 2021 · American Journal of Physiology-Heart and Circulatory Physiology
A Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease
Chongbin Liu, Ming Yang, Li Li, Shilu Luo, Jinfei Yang, Chenrui Li, Jialu Liu, Lin Sun · 2022 · Frontiers in Physiology
Diet-microbiome-gut-brain nexus in acute and chronic brain injury
Maria Krakovski, Niraj Arora, Shalini Jain, Jennifer Glover, Keith E. Dombrowski, Beverly Hernandez, Hariom Yadav, Anand Karthik Sarma · 2022 · Frontiers in Neuroscience
Sodium–glucose cotransporter inhibitors and kidney fibrosis: review of the current evidence and related mechanisms
Barış Afşar, Rengin Elsürer Afşar · 2022 · Pharmacological Reports
Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions
Shivani Srivastava, Vishakha Anand Pawar, Anuradha Tyagi, Kanti Sharma, Vinay Kumar, Surendra Kumar Shukla · 2022 · Immuno
3‐hydroxybutyrate in the brain: Biosynthesis, function, and disease therapy
Bing‐Long Wang, Jian‐Fei Wu, Da Xiao, Bo Wu, Dai‐Xu Wei · 2023 · Brain‐X
Ketogenic metabolic therapy for chronic kidney disease – the pro part
Thomas Weimbs, Jessianna Saville, Kamyar Kalantar‐Zadeh · 2023 · Clinical Kidney Journal
Partial Amelioration of Peripheral and Central Symptoms of Huntington’s Disease via Modulation of Lipid Metabolism
Jane Chen, Conny H. Tran, Lin H. Hwang, Gang Deng, Michael E. Jung, Kym Francis Faull, Michael S. Levine, Carlos Cepeda · 2016 · Journal of Huntington s Disease
Role of HDACs in cardiac electropathology: Therapeutic implications for atrial fibrillation
Bianca J.J.M. Brundel, Jin Li, Deli Zhang · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
NLRP3 Inflammasome: A Novel Player in Metabolically Induced Inflammation—Potential Influence on the Myocardium
Marina Sokolova, Trine Ranheim, Mieke C. Louwe, Bente Lise Halvorsen, Arne Yndestad, Pål Aukrust · 2019 · Journal of Cardiovascular Pharmacology
Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats
Junyu Lin, Zucheng Huang, Junhao Liu, Zhiping Huang, Yapu Liu, Qi Liu, Yang Zhou, Ruoyao Li, Xiuhua Wu, Zhe Shi et al. · 2020 · Frontiers in Neuroscience
β-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1α-mediated angiogenesis
Chongyang Huang, Huishi Tan, Jun Wang, Linwen Huang, Hongbin Liu, Yanqiang Shi, Cailing Zhong, Senhui Weng, Chunhui Chen, Wenyingzi Zhao et al. · 2024 · Cancer Letters
Long-Term Fasting-Induced Ketosis in 1610 Subjects: Metabolic Regulation and Safety
Franziska Grundler, Robin Mesnage, Philip M. M. Ruppert, Demetrios Kouretas, Françoise Wilhelmi de Toledo · 2024 · Nutrients
Metabolism: a potential regulator of neutrophil fate
Zhou Yipeng, Cao Chao, Ranran Li, Pan Tingting, Hongping Qu · 2024 · Frontiers in Immunology
Update on the Efficacy and Safety of Sodium–Glucose Co-Transporter 2 Inhibitors in Patients with Chronic Diseases: A Systematic Review and Meta-Analysis
I-Chia Liang, Hsun-Hao Chang, Yu-Jou Lai, Chi-Ming Chan, Chao-Hsien Sung, Chi‐Ming Pu, Der‐Chen Chang, Ching-Chih Ho, Chi‐Feng Hung · 2025 · Medicina
Fecal Microbiota Transplantation in Alzheimer’s Disease: Mechanistic Insights Through the Microbiota–Gut–Brain Axis and Therapeutic Prospects
Jiayu Ren, Qinwen Wang, Hang Hong, Chunlan Tang · 2025 · Microorganisms
HFpEF and MASLD: converging mechanisms and clinical implications
Federico Capone, Steffen P. Häseli, Luo Liu, Stefano Strocchi, Claudia Langenberg, Aldons Jake Lusis, Maik Pietzner, Deborah M. Muoio, Oliver J. Rider, Betty Raman et al. · 2026 · Nature Reviews Cardiology
The ketogenic diet is not feasible as a therapy in a CD-1 nu/nu mouse model of renal cell carcinoma with features of Stauffer's syndrome
Silvia Vidali, Sepideh Aminzadeh-Gohari, René G. Feichtinger, Renaud Vatrinet, Andreas Koller, Felix Sternberg, Tricia Rutherford, Maura O’Donnel, Andrea Stöger-Kleiber, Bridget Lambert et al. · 2017 · Oncotarget
An updated view on the functions of caspases in inflammation and immunity
Mário Songane, Mostafa Khair, Maya Saleh · 2018 · Seminars in Cell and Developmental Biology
Nutritional Modulation of Innate Immunity: The Fat–Bile–Gut Connection
Raphaël Chèvre, Carlos Silvestre-Roig, Oliver Soehnlein · 2018 · Trends in Endocrinology and Metabolism
Potential Therapeutic Effects of Exogenous Ketone Supplementation for Type 2 Diabetes: A Review
Jeremy James Walsh, Étienne Myette‐Côté, Helena Neudorf, Jonathan P. Little · 2020 · Current Pharmaceutical Design
Mens sana in corpore sano: Does the Glycemic Index Have a Role to Play?
Lionel Carneiro, Corinne Leloup · 2020 · Nutrients
Beneficial effects on kidney during treatment with sodium-glucose cotransporter 2 inhibitors: proposed role of ketone utilization
Yoshiyuki Hattori · 2021 · Heart Failure Reviews
The Effects of Exercise on β-Hydroxybutyrate Concentrations over a 36-h Fast: A Randomized Crossover Study
Landon S. Deru, Benjamin T. Bikman, Lance E. Davidson, Larry A. Tucker, Gilbert W. Fellingham, Ciera L. Bartholomew, HOLLY L. YUAN, Bruce Wayne Bailey · 2021 · Medicine & Science in Sports & Exercise
Function and treatment strategies of β-hydroxybutyrate in aging
Yang Xiang, Qiquan Wang, Xinqiang Lan, Huijie Zhang, Dai‐Xu Wei · 2022 · Smart Materials in Medicine
Seizures, Epilepsy, and NORSE Secondary to Autoimmune Encephalitis: A Practical Guide for Clinicians
Alberto Vogrig, Gian Luigi Gigli, Annacarmen Nilo, Giada Pauletto, Mariarosaria Valente · 2022 · Biomedicines
Immune Dysfunction from Radiation Exposure
David R. Cassatt, Thomas A. Winters, Mercy PrabhuDas · 2023 · Radiation Research
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
Valentina Arrè, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo, Roberto Negro · 2023 · Journal of Biomedical Science
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice
Diego Acuña-Catalán, Samah Shah, Cameron Wehrfritz, Mitsunori Nomura, Alejandro Acevedo, Cristina Olmos, Gabriel Quiroz, Hernán Huerta, Joanna Bons, Estíbaliz Ampuero et al. · 2024 · Cell Reports Medicine
Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice
Xueqin Wang, Yaying Song, Jie Chen, Shuibing Zhang, Yuan Le, Zhongcong Xie, Wen Ouyang, Jianbin Tong · 2019 · Neurotherapeutics
Food and Food Products on the Italian Market for Ketogenic Dietary Treatment of Neurological Diseases
Alessandro Leone, Ramona Silvana De Amicis, Chiara Lessa, Anna Tagliabue, Claudia Trentani, Cinzia Ferraris, Alberto Battezzati, Pierangelo Veggiotti, Andrea Foppiani, Simone Ravella et al. · 2019 · Nutrients