The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
Open accessAbstract
More than 10% of the world's population is chronically infected with HIV, hepatitis C virus (HCV) or hepatitis B virus (HBV), all of which can cause severe disease and death. These viruses persist in part because continuous antigenic stimulation causes the deterioration of virus-specific cytotoxic T lymphocyte (CTL) function and survival. Additionally, antiviral CTLs autonomously suppress their responses to limit immunopathology by upregulating inhibitory receptors such as programmed cell death 1 (PD-1). Identification and blockade of the pathways that induce CTL dysfunction may facilitate the clearance of chronic viral infections. We found that the prostaglandin E2 (PGE2) receptors EP2 and EP4 were upregulated on virus-specific CTLs during chronic lymphocytic choriomeningitis virus (LCMV) infection and suppressed CTL survival and function. We show that the combined blockade of PGE2 and PD-1 signaling was therapeutic in terms of improving viral control and augmenting the numbers of functional virus-specific CTLs. Thus, PGE2 inhibition is both an independent candidate therapeutic target and a promising adjunct therapy to PD-1 blockade for the treatment of HIV and other chronic viral infections.
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Cites
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COX-2 expression positively correlates with PD-L1 expression in human melanoma cells
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Can blocking inflammation enhance immunity during aging?
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Metadata
- Authors
- Chen, J. H., Perry, C. J., Tsui, Y.-C., Staron, M. M., Parish, I. A., Dominguez, C. X., Rosenberg, D. W., & Kaech, S. M.
- Venue
- Nature Medicine
- Published
- 2015-03-23
- Volume
- 21
- Issue
- 4
- Pages
- 327-334
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2019799131
- Cited by
- 172
- References
- 8
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
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