Can blocking inflammation enhance immunity during aging?

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

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Cellular senescence: when bad things happen to good cells

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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Gut microbiota composition correlates with diet and health in the elderly

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Cellular Senescence: Defining a Path Forward

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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DAMPs, PAMPs and alarmins: all we need to know about danger

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

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Obesity and inflammation: the linking mechanism and the complications

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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Composition, variability, and temporal stability of the intestinal microbiota of the elderly

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Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

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Ink4a/Arf expression is a biomarker of aging

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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

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Inflammatory networks during cellular senescence: causes and consequences.

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

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Cellular Senescence in Aging Primates

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p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

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Inflammaging and ‘Garb-aging’

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Ageing and infection

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High mobility group box 1 protein interacts with multiple Toll-like receptors

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Regulation of innate immune cell function by mTOR

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Serum IL‐6 Level and the Development of Disability in Older Persons

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Deubiquitination and Stabilization of PD-L1 by CSN5

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mTOR inhibition improves immune function in the elderly

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Non-Cell-Autonomous Tumor Suppression by p53

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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

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Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

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Identification of HSP90 inhibitors as a novel class of senolytics

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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

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Aging of the innate immune system

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Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1

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p16 ^INK4A is a robust <i>in vivo</i> biomarker of cellular aging in human skin

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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

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Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells

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Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging

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Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

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Expression of <i>p16</i> ^<i>INK4a</i> in peripheral blood T‐cells is a biomarker of human aging

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Tumor Cyclooxygenase-2/Prostaglandin E2–Dependent Promotion of FOXP3 Expression and CD4+CD25+ T Regulatory Cell Activities in Lung Cancer

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TORC1 inhibition enhances immune function and reduces infections in the elderly

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The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

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Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly

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p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

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Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

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Vaccination in the elderly: The challenge of immune changes with aging

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Senescence-associated inflammatory responses: aging and cancer perspectives

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Quantitative identification of senescent cells in aging and disease

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Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States

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Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

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Aging, obesity, and inflammatory age-related diseases

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Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney

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Functional metagenomic profiling of intestinal microbiome in extreme ageing

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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

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Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

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Systemic markers of inflammation and cognitive decline in old age

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Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people

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Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling

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Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

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DAMPs as mediators of sterile inflammation in aging-related pathologies

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The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

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Human CD 8 + EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK

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KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

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Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

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Interleukin‐6, C‐Reactive Protein, and Tumor Necrosis Factor‐Alpha as Predictors of Mortality in Frail, Community‐Living Elderly Individuals

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Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells

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The Associations between Albumin, Globulin, Albumin-to-globulin Ratio, and Frailty in Middle-aged and Older Adults: Evidence from NHANES 2013-2014

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Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes

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PD‐1‐Enhanced Treg Cell Senescence in Advanced Maternal Age

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Influence of individuals’ determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination

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Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals

Scordo, J. M., Piergallini, T. J., Reuter, N., Headley, C. A., Hodara, V. L., González, O., Giavedoni, L. D., Papin, J. F., & Turner, J. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00229-w · Cited by 6 · see citing works

A Novel Systemic Inflammation Prognostic Score to Stratify Survival in Elderly Patients With Cancer

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Age-Dependent Alterations in Intestinal Barrier Function: Involvement of Microbiota and TLR4 Signaling

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Antiinflammatory therapy as a game-changer toward antiaging

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Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures

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Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches

Aiello, A., Calabrò, A., Ligotti, M. E., Accardi, G., Azgomi, M. S., Caccamo, N., Caruso, C., Dieli, F., Manna, M. P. L., Procopio, A., et al. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00506-y · Cited by 4 · see citing works

Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES

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Sarcopenia and rheumatic diseases: is there any connection?

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Pediococcus pentosaceus MIANGUAN Enhances the Immune Response to Vaccination in Mice

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[Palbociclib induces cell cycle arrest and senescence of human renal tubular epithelial cells in vitro].

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Development of therapeutic cancer vaccines based on cancer immunity cycle

Zhang, J., Zheng, Y., Xu, L., Gao, J., Ou, Z., Zhu, M., & Wang, W. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1134-6 · Cited by 2 · see citing works

Immune Aging as a Failure of Programmed Cell Death Coordination

Lee, H.-M., Kim, E.-J., Hasan, A., & Kang, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031554 · Cited by 3 · see citing works

Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis

Chu, R., Xie, Y., Li, W., Du, Y., Ni, T., Tu, X., Xu, B., & Zhao, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1734359 · Cited by 2 · see citing works

"Addressing Aging and Its Associated Diseases: Conceptual Challenges"

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Immunosenescence in elderly patients with advanced non-small cell lung cancer: Mechanisms and therapeutic implications

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Age-Structured Clinical Background Is More Strongly Associated with C-Reactive Protein Levels than Individual Respiratory Viruses During Respiratory Virus Testing

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Nonpharmacologic therapeutic possibilities for immunosenescence

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Systemic cytokines and GlycA discriminate inflammaging, disease progression and corticosteroid response in HTLV-1-associated neuroinflammationPreprint

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AGING WITH T CELLS

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Association of Mortality and Aspirin use for COVID-19 Residents at VA Community Living Center Nursing Homes

Abul, Y., DeVone, F., Bayer, T. A., Halladay, C. W., McConeghy, K. W., Mujahid, N., Singh, M., Leeder, C., Gravenstein, S., & Rudolph, J. L. (2023) · Archives of Internal Medicine Research · doi:10.26502/aimr.0148

Tailoring Vaccines for Older Individuals: Aging of the Immune System and the Impact on Vaccine Efficacy

Bashir, S., Wilson, M., Ashiru-Oredope, D. A. I., & Murdan, S. (2023) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-031-35811-1_9

Immune Response to COVID-19 Vaccination in Frail PatientsPreprint

Liao, S., Wu, L., Li, S., zheng, X., Xu, J., Zhang, X., Yin, M., Ni, J., Zhang, Q., & Yu, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-3896432/v1

Aging: Generation of oxidative stress

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Unprecedented prospects as forthcoming drug targets: New boulevard in the cure and treatment of neurodegenerative disorders

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Can senolysis be used to overcome tumor immune evasion?

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Prostaglandin D2 delays CD8+ T-cell responses and respiratory syncytial virus clearance in geriatric cotton rats

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Biological Age and Aging Clock: Inflammation and Biological Age

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T Cell Aging: An Important Target for Perioperative Immunomodulation

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Additional file 1 of Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals

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Immunological Aging

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Additional file 1 of Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders

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Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virus

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Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer

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Both ageing and frailty status impact vaccine-induced transcriptomic profiles and subsequent humoral immunity: results from the VITAL cohortPreprint

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Targeting senescence-associated biomarkers: Emerging strategies for anti-ageing therapy

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Inflammaging decreases adaptive and innate immune responses in mice and humans

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Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

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Clinical perspectives on the age-related increase of immunosuppressive activity

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Immune system modulation in aging: Molecular mechanisms and therapeutic targets

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Immune Modulation and Its Role in Antiaging

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