The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Prospects for gene-engineered T cell immunotherapy for solid cancers
Open accessAbstract
Adoptive transfer of receptor-engineered T cells has produced impressive results in treating patients with B cell leukemias and lymphomas. This success has captured public imagination and driven academic and industrial researchers to develop similar 'off-the-shelf' receptors targeting shared antigens on epithelial cancers, the leading cause of cancer-related deaths. However, the successful treatment of large numbers of people with solid cancers using this strategy is unlikely to be straightforward. Receptor-engineered T cells have the potential to cause lethal toxicity from on-target recognition of normal tissues, and there is a paucity of truly tumor-specific antigens shared across tumor types. Here we offer our perspective on how expanding the use of genetically redirected T cells to treat the majority of patients with solid cancers will require major technical, manufacturing and regulatory innovations centered around the development of autologous gene therapies targeting private somatic mutations.
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Metadata
- Authors
- Klebanoff, C. A., Rosenberg, S. A., & Restifo, N. P.
- Venue
- Nature Medicine
- Published
- 2016-01
- Volume
- 22
- Issue
- 1
- Pages
- 26-36
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2232549736
- Cited by
- 365
- References
- 147
- FWCI
- 28.12
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
