Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
Saito, Takuro, Nishikawa, Hiroyoshi, Wada, Hisashi, Nagano, Yuji, Sugiyama, Daisuke, Atarashi, Koji, Maeda, Yuka, Hamaguchi, Masahide +14 more·2016·Nature Medicine
DOI 10.1038/nm.4086
Cited by (874)
Items 801–874 of 874
- Spatial Technologies: A Game Changer for Studying the Tumor MicroenvironmentRen Yuan Lee, Mai Chan Lau, Denise L M Goh, Felicia Yu Ting Wee, Jeffrey Chun Tatt Lim, Joe Poh Sheng YEONG · 2025 · Springer eBooks
- Expression Characteristics, Prognostic Value, and Immune-Related Analysis of PPP2R1A in Lung AdenocarcinomaMingyou Dong, HU Yuhong, Shanshan Xiao, Pei Ouyang, Yuejiao Huang, Yawen Li, Xin Zhang, Mei Fei, Lusheng Liao, Qinqin Long · 2025 · Research Square
- Additional file 7 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 1 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implicationsHayashi, Yoshinori, Azumi Ueyama, Funaki, Soichiro, Koichi Jinushi, Higuchi, Naoko, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Saito, Takuro, Kawashima, Atsunari et al. · 2024 · Figshare
- Additional file 9 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 1 of Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characterization in ovarian cancerZhang, Jingjing, Lu, Miao, Xu, Haoya, Ren, Fang, Zhu, Liancheng · 2022 · Figshare
- Additional file 2 of CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulationLiu, Shuna, Tao, Ziqi, 娄鉴芳, Rong Li, Fu, Xin, Xu, Juan, Wang, Ting, Zhang, Lei, Shang, Wenwen, Yepeng Mao et al. · 2024 · Figshare
- Additional file 4 of CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulationLiu, Shuna, Tao, Ziqi, 娄鉴芳, Li, Rong, Fu, Xin, Xu, Juan, Wang, Ting, Zhang, Lei, Shang, Wenwen, Yepeng Mao et al. · 2024 · Figshare
- Additional file 5 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 3 of Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancerSato, Sho, Matsushita, Hirokazu, Daisuke Shintani, Kobayashi, Yukari, Fujieda, Nao, Yabuno, Akira, Tadaaki Nishikawa, Fujiwara, Keiichi, Kakimi, Kazuhiro, Hasegawa, Kosei · 2022 · Figshare
- Additional file 2 of Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancerSato, Sho, Matsushita, Hirokazu, Daisuke Shintani, Kobayashi, Yukari, Fujieda, Nao, Yabuno, Akira, Tadaaki Nishikawa, Fujiwara, Keiichi, Kakimi, Kazuhiro, Hasegawa, Kosei · 2022 · Figshare
- Additional file 2 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implicationsHayashi, Yoshinori, Azumi Ueyama, Funaki, Soichiro, Koichi Jinushi, Higuchi, Naoko, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Saito, Takuro, Kawashima, Atsunari et al. · 2024 · Figshare
- Additional file 2 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 1 of The tumor-stroma ratio in giant cell tumor of bone: associations with the immune microenvironment and responsiveness to denosumab treatmentWu, Hai-Lin, Wang, Xiao-Bin, Li, Jing, Zheng, Bo-Wen · 2024 · Figshare
- Additional file 5 of CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulationLiu, Shuna, Tao, Ziqi, 娄鉴芳, Li, Rong, Fu, Xin, Xu, Juan, Wang, Ting, Zhang, Lei, Shang, Wenwen, Yepeng Mao et al. · 2024 · Figshare
- Additional file 6 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 1 of Predicting response to immunotherapy in gastric cancer via assessing perineural invasion-mediated inflammation in tumor microenvironmentLi, Xunjun, Wang, Yiyun, ZhongYa Zhai, Qingyi Mao, Dianjie Chen, Luxi Xiao, Xu, Shuai, Wu, Qilin, Chen, Keming, Qiantong Hou et al. · 2023 · Figshare
- Additional file 8 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 3 of CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulationLiu, Shuna, Tao, Ziqi, 娄鉴芳, Rong Li, Fu, Xin, Xu, Juan, Wang, Ting, Zhang, Lei, Shang, Wenwen, Yepeng Mao et al. · 2024 · Figshare
- Additional file 1 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 10 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 4 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 5 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implicationsHayashi, Yoshinori, Azumi Ueyama, Funaki, Soichiro, Koichi Jinushi, Higuchi, Naoko, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Saito, Takuro, Kawashima, Atsunari et al. · 2024 · Figshare
- Additional file 4 of Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancerSato, Sho, Matsushita, Hirokazu, Daisuke Shintani, Kobayashi, Yukari, Fujieda, Nao, Yabuno, Akira, Tadaaki Nishikawa, Fujiwara, Keiichi, Kakimi, Kazuhiro, Hasegawa, Kosei · 2022 · Figshare
- Additional file 12 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Hao Liu, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 3 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 13 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 14 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 1 of Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancerSato, Sho, Matsushita, Hirokazu, Daisuke Shintani, Kobayashi, Yukari, Fujieda, Nao, Yabuno, Akira, Tadaaki Nishikawa, Fujiwara, Keiichi, Kakimi, Kazuhiro, Hasegawa, Kosei · 2022 · Figshare
- Additional file 1 of Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populationsLouis Szeponik, Filip Ahlmanner, Patrik Sundström, William Carl Ivar Rodin, Gustavsson, Bengt, Bexe Lindskog, Elinor, Yvonne Wettergren, Marianne Quiding‐Järbrink · 2021 · Figshare
- Additional file 11 of Identification and validation of methylated differentially expressed miRNAs and immune infiltrate profile in EBV-associated gastric cancerZhu, Mansheng, Liang, Qixiang, Chen, Tao, Kong, Qian, Ye, Gengtai, Yu, Shitong, Li, Xunjun, He, Qinglie, Liu, Hao, Hu, Yanfeng et al. · 2021 · Figshare
- Additional file 1 of CD4+CCR8+ Tregs in ovarian cancer: a potential effector Tregs for immune regulationLiu, Shuna, Tao, Ziqi, 娄鉴芳, Rong Li, Fu, Xin, Xu, Juan, Wang, Ting, Zhang, Lei, Shang, Wenwen, Yepeng Mao et al. · 2023 · Figshare
- Additional file 3 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implicationsHayashi, Yoshinori, Azumi Ueyama, Funaki, Soichiro, Koichi Jinushi, Higuchi, Naoko, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Saito, Takuro, Kawashima, Atsunari et al. · 2024 · Figshare
- Additional file 4 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implicationsHayashi, Yoshinori, Azumi Ueyama, Funaki, Soichiro, Koichi Jinushi, Higuchi, Naoko, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Saito, Takuro, Kawashima, Atsunari et al. · 2024 · Figshare
- Not aIL Treg-mediated suppress10n is equalDavid E. J. Klawon, Tyler Jacks · 2026 · Immunity
- Making sense of TILs : recommendations for morphological assessment of tumour‐infiltrating lymphocytes in gastro‐oesophageal carcinomaYlva Weeda, Roberto Salgado, Filip Van Herpe, Daniel Genel Sur, Michael Vieth, Sherene Loi, Ahmad Pahlavan Tafti, Alexandros Hardas, Akira I. Hida, Amarpreet Bhalla et al. · 2026 · Histopathology
- Thrombosis-related gene signature predicts prostate cancer recurrence and immune therapy: insights from retrospective cohorts, bioinformatics, and experimental validationYong Luo, Peixian Chen, Minyi Situ, Wei Zhuang, Jinxing Huang, B. WANG, Qiong Wang, Shengmeng Peng, Hai Huang · 2026 · Inflammation Research
- Biomaterial-mediated reactive oxygen species regulation for Cancer immunotherapy: Mechanisms and applicationsShuning Liu, Run Zhang, Yiqi Jin, Zunzhen Ming, Xingguang Li, Huijing Xiang · 2026 · Coordination Chemistry Reviews
- Regulatory T cells in ovarian cancer: Insights into cancer immunotherapyYueer Chang, Jianyu Yu, Zhixin Qiu, Juan Zhang, Zheng Yang, Jinan He, Na Li, Han Bing Wang · 2026 · Critical Reviews in Oncology/Hematology
- Novel fatty acid metabolism risk score model for guiding treatment in endometrial endometrioid cancerXiaoxiao Xu, Qingmei Wu, Li Liu, Zhengwei Liang, Lieyang Li, Deqin Lu, Sha Lv · 2026 · Scientific Reports
- Impact direct du VEGF-A sur le microenvironnement immunitaire en situation tumorale : modulation par les anti-angiogéniquesThibault Voron · 2019
- Caractérisation de l’infiltrat lymphocytaire cd4 et étude des réponses immunitaires dans le cancer colorectalMarie Kroemer · 2018
- A Study on the Role of the Intestinal MAdCAM-1/alpha4beta7 Axis in Tumor Immunosurveillance During PD-1 BlockadeConrad Rauber · 2019 · theses.fr (ABES)
- The Immune Modulation Role of Low Dosage of Cyclosporin-A (LdCsA) in the Antitumor Response of the Adaptive Immune SystemCamila Flores Torres · 2019 · theses.fr (ABES)
- Contribution à l'identification de marqueurs de la réponse des carcinomes bronchiques non à petites cellules aux immunothérapiesFlorian Guisier · 2019
- Activation des lymphocytes T gamma delta dans les cancersChloé Laplagne · 2020 · theses.fr (ABES)
- Effet anti-tumoral du GTN +/- doxorubicine dans le cancer du sein triple négatif : implication du système immunitaireNesrine Mabrouk · 2021 · theses.fr (ABES)
- Effets toxiques et immunogènes des histones extracellulaires sur les cellules endothéliales au cours du syndrome de lyse tumoraleMarine Arnaud · 2022 · theses.fr (ABES)
- The Evolving Landscape of the Colorectal Cancer Vaccines: From Biological Mechanisms to Translational TherapeuticsSabrina Brigitta Valerie Setiono, Grace L. A. Turalaki, Trina Ekawati Tallei · 2026 · Heca Journal of Applied Sciences
- HVEM : une nouvelle cible prometteuse d'immunothérapie anti-cancéreuseClémence Demerle · 2023
- Influence des neurones sensoriels sur la croissance tumorale et sur la réponse immunitaire anti-tumorale associéeUgo Mardelle · 2024
- Aspirin Enhances Chemosensitivity of Colorectal Cancer Cells by Downregulating FOXP3 to Inhibit ABCB1 ExpressionYi-Xiao Lu, J M Chen, Xiao-Dan Wang, T Wang, Bing-Sheng Liu, Yi-xian CHENG, Guodong Cao, Ting Li · 2026 · Research Square
- Targeting regulatory T cells in gastrointestinal cancers: current status and future perspectivesKoichi Jinushi, Takuro Saito, Yuichiro Doki · 2026 · International Journal of Clinical Oncology
- Systemic application of IL-33 for cancer immunoprevention and immunotherapyJie Liu, Hongyan Wei, Zhenchu Feng, H S Sun, Y Zhang, Wenlong Chen, Xiaoshi Li, Chang Li, Y Zhang, Yixi Ke et al. · 2026 · Molecular Therapy
- SRSF3 determines T reg cell fate in antitumor immunity and autoimmunityRong Jia, Guo J, Linyan Yan, Can Lin, Jun Jia, Jun Shao, Dunfang Zhang, Na Liu, WanJun Chen · 2026 · Science Advances
- Foxp3+/ CD4 + Cell Ratio in Primary Colorectal Cancer Predicts Opposite Prognoses Following Resection of Synchronous or Metachronous Liver MetastasesAndriy V. Trailin, Esraa Ali, Sergii Pavlov, Wenjing Ye, Lenka Červenková, Ondřej Vyčítal, Filip Ambrożkiewicz, Miroslav Jiřík, Ondřej Daum, Václav Liška et al. · 2026 · Cancer Medicine
- Tumor-adapted regulatory T cells: Molecular reprogramming, immune suppression, and therapeutic targeting in cancerMohammad Fayyad‐Kazan · 2026 · Molecular Biology Reports
- Selected Chemokines as Prognostic Biomarkers and Therapeutic Targets in Ovarian CancerAnna Długaszek, Jacek Kabut, Małgorzata Domagała-Haduch, Anita Gorzelak-Magiera, Joanna Sadurska, Maria Laura-Morawiec, Aleksandra Mielczarek‐Palacz, Iwona Gisterek · 2026 · Current Issues in Molecular Biology
- From microbial detection to immune profiling: Analytical strategies for Fusobacterium nucleatum in colorectal cancer and liver metastasisDan Zu, Yuping Zhu, Zhichao Ma, Junkai Xie, Weiping Chen, Yuehua Chen, Guiping Chen, Qinghua Yao, Wei Chen, Chao Xu · 2026 · TrAC Trends in Analytical Chemistry
- IL-6/JAK2/STAT3 axis mediates non-classical monocyte-induced Th17-like conversion of activated Tregs in acute myeloid leukemia patientsXiaoran Dai, Yuanling Zheng, Xu Liu, Ruoyu Huang, Mei Fu, Meijuan Zheng, Yuanhong Xu, Jianyao Huang, Lu Zong · 2026 · BMC Cancer
- Deciphering the colorectal tumor microenvironment: Interactions and targets for effective therapyJingming Zhao, Chong Shi, Yu Du, Guofeng Li, Chengqiu Yan · 2026 · Biochemical Pharmacology
- Coordinated dynamics of circulating neutrophils, regulatory T lymphocytes, myeloid derived suppressor cells and distinct granulocytic subsets reveal a complex immune network in metastatic colorectal cancerZafeiris Zafeiriou, Anna Koutoulaki, Despoina Aggouraki, Filippos Koinis, Nikolaos Vardakis, Alexandra Voutsina, Katerina Papadogiannaki, Konstantia Kotta, Eleni‐Kyriaki Vetsika, Dimitris Mavroudis et al. · 2026 · Frontiers in Oncology
- Regulatory T cells in the bladder cancer tumor microenvironment: mechanisms of immune suppression and therapeutic opportunitiesYusuke Fukiage, Nodoka Okubo, Minekatsu Taga, Yohei Sato, Naoki Terada · 2026 · Frontiers in Molecular Biosciences
- CD47 and FOXP3+ Regulatory Immunity in Colorectal Cancer: A Conceptual Framework for Coordinated ImmunosuppressionQijie Li, Anello Marcello Poma, Donghao Tang, Paola Vignali, Rossella Bruno, Elisabetta Macerola, Beatrice Fuochi, Clara Ugolini · 2026 · Cancers
- Molecular Mechanisms and Immune Regulation in Prostate Cancer: A ReviewNigel P Murray · 2026 · International Journal of Molecular Sciences
- Gut Microbiome Modulation for Colorectal Cancer Therapy: Biomolecule‐Integrated Nanotherapeutic StrategiesPoulami Sarkar, Somasri Shannigrahi, Olivia Sen, Subrata Adak, Priyanka Jana, Sreejan Manna · 2026 · ChemistrySelect
- Targeting immunosuppressive tumor microenvironment to combat immunotherapy resistance: From mechanistic insights to therapeutic strategiesPengfei Su, Yingjing Zhang, Tian Yu, 王元宇, 牟一平, Weiwei Jin · 2026 · International Immunopharmacology
- Spatial Treg niches and the therapeutic reprogramming of tumour tolerance in cancerJhommara Bautista, Miranda Di Capua Delgado, Juliana Viteri-Recalde, Melanie Benítez-Núñez, David Ramírez-Sánchez, Andrés López-Cortés · 2026 · Frontiers in Cell and Developmental Biology
- Microbiome and Diseases: Colorectal CancerSebastian Zeißig, Florian Jokisch, Kenneth Peuker, Klaus‐Peter Janssen · 2026 · Springer eBooks
- In situ APMV-4 vaccination primes systemic response to subtherapeutic dosing of aCTLA-4 in colorectal carcinomaYonina Bykov, Natalia Alonso Moreda, Naseem Sadek, Gloria O Dawodu, Srivatsan Swaminathan, Stephen T. Yeung, Daniel Lozano‐Ojalvo, Javier De Las Rivas, Jeffrey Alan Tomalka, Adolfo García‐Sastre et al. · 2026 · Journal for ImmunoTherapy of Cancer
- Why only 3 months? Immunological constraints on CAR-T therapy in gastrointestinal cancersLiping Zeng, Sheng Wei, Nan Chen, Xiangping Xie · 2026 · Frontiers in Immunology
- Regulatory T cells in lung adenocarcinoma: Mechanisms of immune escape, prognostic significance and therapeutic opportunities (Review)Lijuan Wang, Chenjin Ruan · 2026 · International Journal of Oncology
- ShenqiYichang decoction enhances colorectal cancer immune efficacy via IDO1 mediated reduction of Treg infiltrationYunhe Yang, Lingchang Li, Yuxi Fang, Zhou Yang, Rongtao Xue, Meng Gao, Lamei Zhou, Jian Zhang, Dongjian Zhang · 2026 · Journal of Ethnopharmacology
- Metabolic Dysfunction and T-Cell Exhaustion in Colorectal Cancer: Mechanisms, Microenvironment Remodeling, and Therapeutic OpportunitiesJieun Jeon, Hye Suk Baek, Kibeom Park, Mee‐Na Park, Na Hyeon Heo, SoHyeon Cheon, Gahyeon Kim, Shin Kim · 2026 · International Journal of Molecular Sciences