Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516 · see citing works

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474 · see citing works

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669 · see citing works

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works

FOXP3+ regulatory T cells in the human immune system

Sakaguchi, S., Miyara, M., Costantino, C. M., & Hafler, D. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2785 · Cited by 2,443 · see citing works

Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Sato, E., Olson, S. H., Ahn, J., Bundy, B. N., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509182102 · Cited by 2,375 · see citing works

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.019 · Cited by 2,291 · see citing works

Regulatory T cells, tumour immunity and immunotherapy

Zou, W. (2006) · Nature reviews. Immunology · doi:10.1038/nri1806 · Cited by 2,075 · see citing works

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490 · see citing works

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327 · see citing works

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer

Tosolini, M., Kirilovsky, A., Mlecnik, B., Fredriksen, T., Mauger, S., Bindea, G., Berger, A., Bruneval, P., Fridman, W.-H., Pagès, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2907 · Cited by 1,146 · see citing works

<i>Fusobacterium nucleatum</i> in colorectal carcinoma tissue and patient prognosis

Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310101 · Cited by 1,080 · see citing works

Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

Salama, P. R., Phillips, M. R., Grieu, F., Morris, M. J., Zeps, N., Joseph, D. J., Platell, C. F. E., & Iacopetta, B. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7229 · Cited by 992 · see citing works

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

Pagès, F., Kirilovsky, A., Mlecnik, B., Asslaber, M., Tosolini, M., Bindea, G., Lagorce, C., Wind, P., Marliot, F., Bruneval, P., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.6147 · Cited by 953 · see citing works

Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses

Joller, N., Lozano, E., Burkett, P. R., Patel, B., Xiao, S., Zhu, C., Xia, J., Tan, T.-G., Sefik, E., Yajnik, V., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.012 · Cited by 904 · see citing works

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756 · see citing works

Regulatory T cells in cancer immunotherapy

Nishikawa, H., & Sakaguchi, S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.12.005 · Cited by 702 · see citing works

Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700 · see citing works

<i>Fusobacterium nucleatum</i> and T Cells in Colorectal Carcinoma

Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works

Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells, evoking antitumor immune responses in humans

Sugiyama, D., Nishikawa, H., Maeda, Y., Nishioka, M., Tanemura, A., Katayama, I., Ezoe, S., Kanakura, Y., Sato, E., Fukumori, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316796110 · Cited by 629 · see citing works

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

Wu, P., Wu, D., Ni, C., Ye, J., Chen, W., Hu, G., Wang, Z., Wang, C., Zhang, Z., Xia, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.013 · Cited by 608 · see citing works

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

deLeeuw, R., Kost, S., Kakal, J., & Nelson, B. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3216 · Cited by 444 · see citing works

Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers

Said, H. S., Suda, W., Nakagome, S., Chinen, H., Oshima, K., Kim, S., Kimura, R., Iraha, A., Ishida, H., Fujita, J., et al. (2013) · DNA Research · doi:10.1093/dnares/dst037 · Cited by 394 · see citing works

Robustness of Gut Microbiota of Healthy Adults in Response to Probiotic Intervention Revealed by High-Throughput Pyrosequencing

Kim, S.-W., Suda, W., Kim, S., Oshima, K., Fukuda, S., Ohno, H., Morita, H., & Hattori, M. (2013) · DNA Research · doi:10.1093/dnares/dst006 · Cited by 338 · see citing works

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Rech, A. J., Mick, R., Martin, S., Recio, A., Aqui, N. A., Powell, D. J., Colligon, T. A., Trosko, J. A., Leinbach, L. I., Pletcher, C. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003330 · Cited by 335 · see citing works

High frequency of tumor‐infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair‐proficient colorectal cancer patients

Frey, D. M., Droeser, R. A., Viehl, C. T., Zlobec, I., Lugli, A., Zingg, U., Oertli, D., Kettelhack, C., Terracciano, L., & Tornillo, L. (2009) · International Journal of Cancer · doi:10.1002/ijc.24989 · Cited by 335 · see citing works

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

Sinicrope, F. A., Rego, R. L., Ansell, S. M., Knutson, K. L., Foster, N. R., & Sargent, D. J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.053 · Cited by 329 · see citing works

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

Berg, J. V., Vrohlings, M., Haller, S., Haimovici, A., Kulig, P., Śledzińska, A., Weller, M., & Becher, B. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130678 · Cited by 214 · see citing works

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D. M., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004566 · Cited by 214 · see citing works

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

Yamaguchi, T., Kishi, A., Osaki, M., Morikawa, H., Martín, P. P., Wing, K., Saito, T., & Sakaguchi, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307185110 · Cited by 109 · see citing works

Regulatory T cells in cancer immunotherapy

Tanaka, A., & Sakaguchi, S. (2017) · Cell Research · doi:10.1038/cr.2016.151 · Cited by 1,860 · see citing works

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Bruni, D., Angell, H. K., & Galon, J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0285-7 · Cited by 1,586 · see citing works

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

Togashi, Y., Shitara, K., & Nishikawa, H. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0175-7 · Cited by 1,553 · see citing works

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Initiative, A. P. C. G., Balachandran, V. P., Łuksza, M., Zhao, J. N., Makarov, V., Moral, J. A., Remark, R., Herbst, B., Askan, G., Bhanot, U., et al. (2017) · Nature · doi:10.1038/nature24462 · Cited by 1,191 · see citing works

Regulatory T Cells and Human Disease

Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,133 · see citing works

Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?

Ohue, Y., & Nishikawa, H. (2019) · Cancer Science · doi:10.1111/cas.14069 · Cited by 1,046 · see citing works

T cells in health and disease

Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,057 · see citing works

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

Dienstmann, R., Vermeulen, L., Guinney, J., Kopetz, S., Tejpar, S., & Tabernero, J. M. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2016.126 · Cited by 1,038 · see citing works

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Kamada, T., Togashi, Y., Tay, C., Ha, D., Sasaki, A., Nakamura, Y., Sato, E., Fukuoka, S., Tada, Y., Tanaka, A., et al. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1822001116 · Cited by 905 · see citing works

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Kumagai, S., Koyama, S., Itahashi, K., Tanegashima, T., Lin, Y.-T., Togashi, Y., Kamada, T., Irie, T., Okumura, G., Kono, H., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.01.001 · Cited by 892 · see citing works

Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Cai, J., Sun, L., & Gonzalez, F. J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.02.004 · Cited by 855 · see citing works

Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms

Tay, R. E., Richardson, E. K., & Toh, H. C. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0183-x · Cited by 801 · see citing works

Regulatory mechanisms of PD-1/PD-L1 in cancers

Lin, X., Kang, K., Chen, P., Zeng, Z., Li, G., Xiong, W., Yi, M., & Xiang, B. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02023-w · Cited by 850 · see citing works

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Kumagai, S., Togashi, Y., Kamada, T., Sugiyama, E., Nishinakamura, H., Takeuchi, Y., Kochin, V., Itahashi, K., Maeda, Y., Matsui, S., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0769-3 · Cited by 794 · see citing works

Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

Maj, T., Wang, W., Crespo, J., Zhang, H., Wang, W., Wei, S., Zhao, L., Vatan, L., Shao, I., Szeliga, W., et al. (2017) · Nature Immunology · doi:10.1038/ni.3868 · Cited by 733 · see citing works

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726 · see citing works

Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy

Tan, W. C. C., Nerurkar, S. N., Cai, H. Y., Ng, H. H. M., Wu, D., Wee, F. Y. T., Lim, J. C. T., Yeong, J. P.-S., & Lim, T. K. H. (2020) · 癌症：英文版 · doi:10.1002/cac2.12023 · Cited by 690 · see citing works

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Wang, H., Franco, F., Tsui, Y.-C., Xie, X., Trefny, M. P., Zappasodi, R., Mohmood, S. R., Fernández-García, J., Tsai, C.-H., Schulze, I., et al. (2020) · Nature Immunology · doi:10.1038/s41590-019-0589-5 · Cited by 680 · see citing works

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

Overacre-Delgoffe, A. E., Chikina, M., Dadey, R. E., Yano, H., Brunazzi, E. A., Shayan, G., Horne, W., Moskovitz, J. M., Kolls, J. K., Sander, C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.005 · Cited by 627 · see citing works

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study

Ali, H. R., Chlon, L., Pharoah, P. D. P., Markowetz, F. M., & Caldas, C. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002194 · Cited by 611 · see citing works

Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy

Tay, C., Tanaka, A., & Sakaguchi, S. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.014 · Cited by 590 · see citing works

Two-step enhanced cancer immunotherapy with engineered <i>Salmonella typhimurium</i> secreting heterologous flagellin

Zheng, J. H., Nguyen, V. H., Jiang, S.-N., Park, S.-H., Tan, W., Hong, S. H., Shin, M. G., Chung, I.-J., Hong, Y., Bom, H.-S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aak9537 · Cited by 588 · see citing works

Roles of regulatory T cells in cancer immunity

Takeuchi, Y., & Nishikawa, H. (2016) · International Immunology · doi:10.1093/intimm/dxw025 · Cited by 517 · see citing works

Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer

Picard, E., Verschoor, C. P., Grace, W. K., & Pawelec, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00369 · Cited by 520 · see citing works

Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting

Chaudhary, B., & Elkord, E. (2016) · Vaccines · doi:10.3390/vaccines4030028 · Cited by 516 · see citing works

CD4+ T cells in cancer

Speiser, D. E., Chijioke, O., Schaeuble, K., & Münz, C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00521-2 · Cited by 486 · see citing works

Targeting Treg cells in cancer immunotherapy

Tanaka, A., & Sakaguchi, S. (2019) · European Journal of Immunology · doi:10.1002/eji.201847659 · Cited by 479 · see citing works

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Ye, Y., Dai, Q., & Qi, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00451-x · Cited by 451 · see citing works

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy

Li, X., Shao, C., Shi, Y., & Han, W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0578-4 · Cited by 385 · see citing works

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

Gu-Trantien, C., Migliori, E., Buisseret, L., de Wind, A., Brohée, S., Garaud, S., Noël, G., Dang Chi, V. L., Lodewyckx, J.-N., Naveaux, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91487 · Cited by 368 · see citing works

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

Goswami, S., Walle, T., Cornish, A. E., Basu, S., Anandhan, S., Fernandez, I., Vence, L., Blando, J., Zhao, H., Yadav, S. S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-019-0694-x · Cited by 356 · see citing works

Principles and therapeutic applications of adaptive immunity

Chi, H., Pepper, M., & Thomas, P. G. (2024) · Cell · doi:10.1016/j.cell.2024.03.037 · Cited by 359 · see citing works

The gut microbial metabolite formate exacerbates colorectal cancer progression

Ternes, D., Tsenkova, M., Pozdeev, V. I., Meyers, M., Koncina, E., Atatri, S., Schmitz, M., Karta, J., Schmoetten, M., Heinken, A., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00558-0 · Cited by 335 · see citing works

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

Drewes, J. L., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., et al. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-017-0040-3 · Cited by 335 · see citing works

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

Wang, D., Quiros, J., Mahuron, K., Pai, C.-C., Ranzani, V., Young, A., Silveria, S., Harwin, T., Abnousian, A., Pagani, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.050 · Cited by 318 · see citing works

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

Koyama, S., & Nishikawa, H. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002591 · Cited by 307 · see citing works

CTLA-4 in Regulatory T Cells for Cancer Immunotherapy

Sobhani, N., Tardiel-Cyril, D. R., Davtyan, A., Generali, D., Roudi, R., & Li, Y. (2021) · Cancers · doi:10.3390/cancers13061440 · Cited by 307 · see citing works

Immune checkpoint inhibitors in cancer therapy: a focus on T‐regulatory cells

Nair, V. S., & Elkord, E. (2017) · Immunology and Cell Biology · doi:10.1111/imcb.1003 · Cited by 301 · see citing works

Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

Cervantes‐Villagrana, R. D., Albores‐García, D., Cervantes-Villagrana, A. R., & García-Acevez, S. J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0205-z · Cited by 299 · see citing works

Regulatory T cells in the treatment of disease

Sharabi, A., Tsokos, M., Ding, Y., Malek, T. R., Klatzmann, D., & Tsokos, G. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.148 · Cited by 297 · see citing works

Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR -mutated non–small cell lung cancer

Sugiyama, E., Togashi, Y., Takeuchi, Y., Shinya, S., Tada, Y., Kataoka, K., Tane, K., Sato, E., Ishii, G., Goto, K., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aav3937 · Cited by 292 · see citing works

The Prognostic Implications of Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Systematic Review and Meta-Analysis

Idos, G., Kwok, J., Bonthala, N. N., Kysh, L., Gruber, S. B., & Qu, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-60255-4 · Cited by 290 · see citing works

Gut microbiota modulate T cell trafficking into human colorectal cancer

Cremonesi, E., Governa, V., Garzon, J. F. G., Mele, V., Amicarella, F., Muraro, M. G., Trella, E., Galati-Fournier, V., Oertli, D., Däster, S. R., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313498 · Cited by 275 · see citing works

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 263 · see citing works

Dual Effect of Immune Cells within Tumour Microenvironment: Pro- and Anti-Tumour Effects and Their Triggers

Peña-Romero, A. C., & Orenes‐Piñero, E. (2022) · Cancers · doi:10.3390/cancers14071681 · Cited by 261 · see citing works

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

Kumagai, S., Togashi, Y., Sakai, C., Kawazoe, A., Kawazu, M., Ueno, T., Sato, E., Kuwata, T., Kinoshita, T., Yamamoto, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.016 · Cited by 256 · see citing works

<i>Fusobacterium nucleatum</i>and colorectal cancer: A review

Shang, F.-M., & Liu, H.-L. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i3.71 · Cited by 258 · see citing works

IFN-γ: A cytokine at the right time, is in the right place

Burke, J. D., & Young, H. A. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.05.002 · Cited by 263 · see citing works

Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

Ternes, D., Karta, J., Tsenkova, M., Wilmes, P., Haan, S., & Letellier, E. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.01.001 · Cited by 256 · see citing works

Therapeutic targeting of regulatory T cells in cancer

Shan, F., Somasundaram, A., Bruno, T. C., Workman, C. J., & Vignali, D. A. A. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.06.008 · Cited by 246 · see citing works

Tumour-infiltrating lymphocytes: from prognosis to treatment selection

Brummel, K., Eerkens, A. L., de Bruyn, M., & Nijman, H. W. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02119-4 · Cited by 243 · see citing works

Synthetic cytokine circuits that drive T cells into immune-excluded tumors

Allen, G. M., Frankel, N. W., Reddy, N. R., Bhargava, H. K., Yoshida, M. A., Stark, S. R., Purl, M. C., Lee, J., Yee, J. L., Yu, W., et al. (2022) · Science · doi:10.1126/science.aba1624 · Cited by 244 · see citing works

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K., & Datta, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01228 · Cited by 237 · see citing works

Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

Collier, J. L., Weiss, S. A., Pauken, K. E., Sen, D. R., & Sharpe, A. H. (2021) · Nature Immunology · doi:10.1038/s41590-021-00949-7 · Cited by 237 · see citing works

Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation

Shalapour, S., & Karin, M. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.021 · Cited by 229 · see citing works

Rational design of anti-GITR-based combination immunotherapy

Zappasodi, R., Sirard, C. A., Li, Y., Budhu, S., Abu-Akeel, M., Liu, C., Yang, X., Zhong, H., Newman, W., Qi, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0420-8 · Cited by 227 · see citing works

The Complex Role of Regulatory T Cells in Immunity and Aging

Rocamora‐Reverte, L., Melzer, F. L., Würzner, R., & Weinberger, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616949 · Cited by 230 · see citing works

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity

Kumar, P., Bhattacharya, P., & Prabhakar, B. S. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.08.007 · Cited by 217 · see citing works

Regulatory T cells: a potential target in cancer immunotherapy

Shitara, K., & Nishikawa, H. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13625 · Cited by 215 · see citing works

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment

Tada, Y., Togashi, Y., Kotani, D., Kuwata, T., Sato, E., Kawazoe, A., Doi, T., Wada, H., Nishikawa, H., & Shitara, K. (2018) · Journal of Immunotherapy for Cancer · doi:10.1186/s40425-018-0403-1 · Cited by 181 · see citing works

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Kidani, Y., Nogami, W., Yasumizu, Y., Kawashima, A., Tanaka, A., Sonoda, Y., Tona, Y., Nashiki, K., Matsumoto, R., Hagiwara, M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114282119 · Cited by 212 · see citing works

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody

Ha, D., Tanaka, A., Kibayashi, T., Tanemura, A., Sugiyama, D., Wing, J. B., Lim, E. L., Teng, K. W. W., Adeegbe, D., Newell, E. W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812186116 · Cited by 205 · see citing works

Tumor-infiltrating human CD4 + regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

Ahmadzadeh, M., Pasetto, A., Jia, L., Deniger, D. C., Stevanović, S., Robbins, P. F., & Rosenberg, S. A. (2019) · Science Immunology · doi:10.1126/sciimmunol.aao4310 · Cited by 202 · see citing works

Role of PD-1 in Immunity and Diseases

Chamoto, K., Al-Habsi, M., & Honjo, T. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_67 · Cited by 198 · see citing works

Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

Hanus, M., Parada‐Venegas, D., Landskron, G., Wielandt, A. M., Hurtado, C., Álvarez, K., Hermoso, M. A., López-Köstner, F., & la Fuente, M. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612826 · Cited by 201 · see citing works

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity

Whiteside, T. L. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1451514 · Cited by 196 · see citing works

Profiles of immune infiltration in colorectal cancer and their clinical significant: A gene expression‐based study

Xiong, Y., Wang, K., Zhou, H., Peng, L., You, W., & Fu, Z. (2018) · Cancer Medicine · doi:10.1002/cam4.1745 · Cited by 196 · see citing works

Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment

Scott, E., Gocher, A., Workman, C., & Vignali, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702726 · Cited by 174 · see citing works

Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation

Ferris, R. L., Lenz, H., Trotta, A. M., García‐Foncillas, J., Schulten, J., Audhuy, F., Merlano, M. C., & Milano, G. A. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.11.008 · Cited by 190 · see citing works

Modulating Treg stability to improve cancer immunotherapy

Kang, J. H., & Zappasodi, R. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.07.015 · Cited by 187 · see citing works

Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion

Wang, D., Yang, L., Yue, D., Cao, L., Li, L., Wang, D., Ping, Y., Shen, Z., Zheng, Y., Wang, L., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.03.040 · Cited by 183 · see citing works

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma

Wang, Z., He, L., Li, W., Xu, C., Zhang, J., Wang, D., Dou, K., Zhuang, R., Jin, B., Zhang, W., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002787 · Cited by 180 · see citing works

Preoperative Chemoradiotherapy plus Nivolumab before Surgery in Patients with Microsatellite Stable and Microsatellite Instability–High Locally Advanced Rectal Cancer

Bando, H., Tsukada, Y., Inamori, K., Togashi, Y., Koyama, S., Kotani, D., Fukuoka, S., Yuki, S., Komatsu, Y., Homma, S., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3213 · Cited by 182 · see citing works

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

Downs‐Canner, S., Berkey, S. E., Delgoffe, G. M., Edwards, R. P., Curiel, T. J., Odunsi, K. O., Bartlett, D. L., & Obermajer, N. (2017) · Nature Communications · doi:10.1038/ncomms14649 · Cited by 176 · see citing works

Effects of tumor metabolic microenvironment on regulatory T cells

Wang, Y., Li, X., Mo, Y., Fan, C., Tang, L. M., Xiong, F., Guo, C. J., Xiang, B., Zhou, M., Ma, J., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0913-y · Cited by 176 · see citing works

Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus

Dall’Era, M., Pauli, M. L., Remedios, K. A., Taravati, K., Sandova, P. M., Putnam, A. L., Lares, A., Haemel, A. K., Tang, Q., Hellerstein, M. K., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40737 · Cited by 170 · see citing works

Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine

Ogino, S., Nowak, J. A., Hamada, T., Phipps, A. I., Peters, U., Milner, D. A., Giovannucci, E. L., Nishihara, R., Giannakis, M., Garrett, W. S., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315537 · Cited by 169 · see citing works

The Colorectal Cancer Tumor Microenvironment and Its Impact on Liver and Lung Metastasis

Chandra, R., Karalis, J. D., Liu, C., Murimwa, G. Z., Park, J. V., Heid, C. A., Reznik, S. I., Huang, E. H., Minna, J. D., & Brekken, R. A. (2021) · Cancers · doi:10.3390/cancers13246206 · Cited by 165 · see citing works

Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential

Wang, L., Liang, Y., Zhao, C., Ma, P., Zeng, S., Ju, D., Zhao, M., Yu, M., & Shi, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02326-4 · Cited by 177 · see citing works

Flicr , a long noncoding RNA, modulates Foxp3 expression and autoimmunity

Zemmour, D., Pratama, A., Loughhead, S. M., Mathis, D. J., & Benoist, C. O. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700946114 · Cited by 163 · see citing works

Immune suppression and reversal of the suppressive tumor microenvironment

Shimizu, K., Iyoda, T., Okada, M., Yamasaki, S., & Fujii, S. (2018) · International Immunology · doi:10.1093/intimm/dxy042 · Cited by 159 · see citing works

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients

Toor, S. M., Murshed, K., Al‐Dhaheri, M., Khawar, M., Nada, M. A., & Elkord, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02936 · Cited by 160 · see citing works

Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine

Kumagai, S., Itahashi, K., & Nishikawa, H. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00870-6 · Cited by 163 · see citing works

Bacterial Biofilms in Colorectal Cancer Initiation and Progression

Li, S., Konstantinov, S. R., Smits, R., & Peppelenbosch, M. P. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.004 · Cited by 154 · see citing works

Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery

Tian, R., Ma, H., Yang, Q., Wan, H., Zhu, S., Chandra, S., Sun, H., Kiesewetter, D. O., Niu, G., Liang, Y., et al. (2018) · Chemical Science · doi:10.1039/c8sc03751e · Cited by 151 · see citing works

Predictive biomarkers of colon cancer immunotherapy: Present and future

Hou, W., Cheng, Y., & Zhu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1032314 · Cited by 147 · see citing works

Regulatory T Cells in Cancer

Plitas, G., & Rudensky, A. Y. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033428 · Cited by 148 · see citing works

Molecular Cancer Imaging in the Second Near‐Infrared Window Using a Renal‐Excreted NIR‐II Fluorophore‐Peptide Probe

Wang, W., Ma, Z., Zhu, S., Wan, H., Yue, J., Ma, H., Ma, R., Yang, Q., Wang, Z., Li, Q., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800106 · Cited by 148 · see citing works

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

Laissue, P. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0938-x · Cited by 143 · see citing works

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

Magnuson, A. M., Kiner, E., Ergün, A., Park, J. S., Asinovski, N., Ortiz-Lopez, A., Kilcoyne, A., Paoluzzi-Tomada, E., Weissleder, R., Mathis, D. J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810580115 · Cited by 144 · see citing works

Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy

Kim, J.-H., Kim, B. S., & Lee, S. (2020) · Immune Network · doi:10.4110/in.2020.20.e4 · Cited by 143 · see citing works

Exploring the Role of Gut Microbiome in Colon Cancer

Chattopadhyay, I., Dhar, R., Pethusamy, K., Seethy, A. A., Srivastava, T. P., Sah, R., Sharma, J. N., & Karmakar, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03498-9 · Cited by 139 · see citing works

CD4+ T cells in antitumor immunity

Montauti, E. I., Oh, D. Y., & Fong, L. H. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.07.009 · Cited by 140 · see citing works

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

Brockmann, L., Soukou, S., Steglich, B., Czarnewski, P., Zhao, L., Wende, S., Bedke, T., Ergen, C., Manthey, C., Agalioti, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07581-4 · Cited by 131 · see citing works

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

Cuadrado, E., van den Biggelaar, M., de Kivit, S., Chen, Y.-Y., Slot, M., Doubal, I., Meijer, A., van Lier, R. A. W., Borst, J., & Amsen, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.008 · Cited by 132 · see citing works

Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape

Takeuchi, Y., Tanegashima, T., Sato, E., Irie, T., Sai, A., Itahashi, K., Kumagai, S., Tada, Y., Togashi, Y., Koyama, S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abc6424 · Cited by 132 · see citing works

Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases

Cheng, Y., Yano, H., Workman, C. J., & Vignali, D. A. A. (2021) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2021.0147 · Cited by 126 · see citing works

Development of mi RNA ‐based therapeutic approaches for cancer patients

Takahashi, R., Prieto‐Vila, M., Kohama, I., & Ochiya, T. (2019) · Cancer Science · doi:10.1111/cas.13965 · Cited by 125 · see citing works

Regulatory T‐cell heterogeneity and the cancer immune response

Ward‐Hartstonge, K. A., & Kemp, R. A. (2017) · Clinical &amp; Translational Immunology · doi:10.1038/cti.2017.43 · Cited by 122 · see citing works

IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

Whitehouse, G. P., Gray, E. H., Mastoridis, S., Merritt, E., Kodela, E., Yang, J. H. M., Danger, R., Mairal, M., Christakoudi, S., Lozano, J. J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620835114 · Cited by 122 · see citing works

Abstract B174: FOXP3+CD4+ T-cell subpopulations distinctly control the prognosis of colorectal cancers

Saito, T., Nishikawa, H., Wada, H., Mori, M., Doki, Y., & Sakaguchi, S. (2016) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr15-b174

Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer

Ladoire, S., Martin, F., & Ghiringhelli, F. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1046-y · Cited by 331 · see citing works

Distribution of CD4~+CD25~+FOXP3~+ regulatory T cells and their subsets in colorectal carcinoma and the clinical significance

Xiao, G. (2010) · Zhongguo mianyixue zazhi

In situ analysis of FOXP3+ regulatory T cells and myeloid dendritic cells in human colorectal cancer tissue and tumor-draining lymph node

Gai, X., Li, C., Song, Y., Lei, Y., & Yang, B. (2012) · Biomedical Reports · doi:10.3892/br.2012.35 · Cited by 15 · see citing works

Colorectal carcinoma is infiltrated by FOXP3-positivelymphocytes

Garajová, I., Fabián, P., Nenutil, R., Kocáková, I., Grell, P., Hanzelková, Z., Vyzula, R., & Svoboda, M. (2007)