Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
He, Zhuohao, Guo, Jing L, McBride, Jennifer D, Narasimhan, Sneha, Kim, Hyesung, Changolkar, Lakshmi, Zhang, Bin, Gathagan, Ronald J +9 more·2018·Nature Medicine
DOI 10.1038/nm.4443
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- Early detection and personalized medicine: Future strategies against Alzheimer's diseaseAntonio Di Meco, Robert J. Vassar · 2020 · Progress in molecular biology and translational science
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