Validating Stat3 in cancer therapy

Darnell, James E·2005·Nature Medicine
DOI 10.1038/nm0605-595

Cited by (316)

Items 101–200 of 316

  1. Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes
    Arnab Basu, Keith Meyer, Keith Lai, Kousuke Saito, Adrian M. Di Bisceglie, Leonard E. Grosso, Ratna B. Ray, Ranjit Ray · 2006 · Virology
  2. Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancer
    Teng Ji, Danni Gong, Zhiqiang Han, Wei Xiao, Yuting Yan, Fei Ye, Wencheng Ding, Junnai Wang, Xi Xia, Fei Li et al. · 2013 · Cancer Letters
  3. A Cell-permeable Stat3 SH2 Domain Mimetic Inhibits Stat3 Activation and Induces Antitumor Cell Effects in Vitro
    Wei Ming Zhao, Soumya Jaganathan, James Turkson · 2010 · Journal of Biological Chemistry
  4. Hydroxamic Acid and Benzoic Acid–Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo
    Peibin Yue, Francisco Lopez‐Tapia, David Paladino, Yifei Li, Chih‐Hong Chen, Andrew T. Namanja, Tyvette S. Hilliard, Yuan Chen, Marcus A. Tius, James Turkson · 2015 · Cancer Research
  5. Critical role of STAT3 in melanoma metastasis through anoikis resistance
    Neel Manoj Fofaria, Sanjay Srivastava · 2014 · Oncotarget
  6. Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila
    Laura A. Ekas, Timothy J. Cardozo, Maria Sol Flaherty, Elizabeth A. McMillan, Foster C. Gonsalves, Erika A Bach · 2010 · Developmental Biology
  7. STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts
    David W. Waters, Kaj E. C. Blokland, Prabuddha S. Pathinayake, Lan Wei, Michael J. Schuliga, Jade Jaffar, Glen Philip Westall, Philip M. Hansbro, Cecilia M. Prêle, Steven Eugene Mutsaers et al. · 2019 · American Journal of Respiratory Cell and Molecular Biology
  8. Modulation of antigen‐presenting cells by HDAC inhibitors: implications in autoimmunity and cancer
    Karrune V. Woan, Eva Sahakian, Eduardo M. Sotomayor, Edward Seto, Alejandro Villagra · 2011 · Immunology and Cell Biology
  9. Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
    María A. Rodríguez-Hernández, Patricia de la Cruz‐Ojeda, María José López-Grueso, Elena Navarro‐Villarán, Raquel Requejo-Aguilar, Beatriz Castejón‐Vega, María Negrete, Paloma Gallego, Álvaro Vega-Ochoa, Víctor M. Víctor et al. · 2020 · Redox Biology
  10. TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
    Andreas Herrmann, Gregory Allan Cherryholmes, Anne Schroeder, Jillian A. Phallen, Darya Alizadeh, Hong Xin, Tianyi Wang, Heehyoung Lee, Christoph Lahtz, Piotr M. Swiderski et al. · 2014 · Cancer Research
  11. Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions
    Wei Yan, Bing Tu, Yunyun Liu, Tingyu Wang, Han Qiao, Zanjing Zhai, Haowei Li, Tingting Tang · 2013 · Bone Research
  12. Genome‐wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway
    Maria Sol Flaherty, Jiří Zavadil, Laura A. Ekas, Erika A Bach · 2009 · Developmental Dynamics
  13. (−)-Epigallocatechin Gallate Induces Fas/CD95-Mediated Apoptosis through Inhibiting Constitutive and IL-6-Induced JAK/STAT3 Signaling in Head and Neck Squamous Cell Carcinoma Cells
    Hui-Yi Lin, Shin-Chen Hou, Shi-Chen Chen, Ming‐Ching Kao, Chien-Chih Yu, Shinji Funayama, Chi‐Tang Ho, Tzong‐Der Way · 2012 · Journal of Agricultural and Food Chemistry
  14. IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling
    Cheng-Fen Chen, Xue-Jun Zhang · 2017 · Journal of Translational Medicine
  15. Stat3 isoforms, α and β, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3β mapping to its unique C-terminal end
    Huang, Ying, Qiu, Jihui, Dong, Shuo, Redell, Michele S., Poli, Valeria, Mancini, Michael A., Tweardy, David J. · 2007 · Journal of Biological Chemistry
  16. Regulation of STATs by polycystin-1 and their role in polycystic kidney disease
    Thomas Weimbs, Erin E. Olsan, Jeffrey J. Talbot · 2013 · JAK-STAT
  17. HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop
    Zanobia Syed, Weihong Yin, Kendall Hughes, Jennifer N. Gill, Runhua Shi, John L. Clifford · 2011 · BMC Cancer
  18. Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC
    Michael D. Hadjidaniel, Sakunthala Muthugounder, Long T. Hung, Michael Allen Sheard, Soheila Shirinbak, Randall Y. Chan, Rie Nakata, Lucia Borriello, Jemily Malvar, Rebekah J. Kennedy et al. · 2017 · Oncotarget
  19. Dimeric Approaches to Anti-Cancer Chemotherapeutics
    Matthew Kyle Hadden, Brian S. J. Blagg · 2008 · Anti-Cancer Agents in Medicinal Chemistry
  20. Follicular helper T‐cells: expanding roles in T‐cell lymphoma and targets for treatment
    Matthew J. Ahearne, Rebecca L. Allchin, Christopher Paul Fox, Simon D. Wagner · 2014 · British Journal of Haematology
  21. An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma
    Sorah Yoon, Xiwei Wu, Brian Armstrong, Nagy Adley Habib, John J. Rossi · 2018 · Molecular Therapy — Nucleic Acids
  22. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
    Jin, Jinmei, Wu, Yaping, Zhao, Zeng, Wu, Ye, Zhou, Yu-dong, Liu, Sanhong, Sun, Qingyan, Yang, Guizhu, Lin, Jiayi, Nagle, Dale G. et al. · 2022 · JCI Insight
  23. Thioredoxin Signaling Pathways in Cancer
    Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang · 2022 · Antioxidants and Redox Signaling
  24. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)
    Haijun Chen, Zhengduo Yang, Chunyong Ding, Ailian Xiong, Christopher Wild, Lili Wang, Na Ye, Guoshuai Cai, Rudolfo M. Flores, Ye Ding et al. · 2014 · European Journal of Medicinal Chemistry
  25. Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
    Maureen M. Sherry-Lynes, Sejuti Sengupta, Shreya Kulkarni, Brent Cochran · 2017 · PLoS ONE
  26. Targeting signal transducers and activators of transcription (STAT) in human cancer by dietary polyphenolic antioxidants
    Hamed Amani, Marjan Ajami, Solmaz Nasseri Maleki, Hamidreza Pazoki–Toroudi, Maria Daglia, Arold Jorel Tsetegho Sokeng, Arianna Di Lorenzo, Seyed Fazel Nabavi, Kasi Pandima Devi, Seyed Mohammad Nabavi · 2017 · Biochimie
  27. Pancreatic cancer chemoprevention by phytochemicals
    Srinivas Reddy Boreddy, Sanjay Srivastava · 2012 · Cancer Letters
  28. Cell Density–Dependent Increase of Constitutive Signal Transducers and Activators of Transcription 3 Activity in Melanoma Cells Is Mediated by Janus Kinases
    Stephanie Kreis, Georg A. Munz, Serge Haan, Peter Claus Heinrich, Iris Behrmann · 2007 · Molecular Cancer Research
  29. Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture
    Tianfu Dong, Youde Yan, Hao Chai, Shenglin Chen, Xinkui Xiong, Daoyi Sun, Yue Yu, Lei Deng, Feng Cheng · 2014 · Biomedicine & Pharmacotherapy
  30. Upregulation of STAT3 Marks Burkitt Lymphoma Cells Refractory to Epstein-Barr Virus Lytic Cycle Induction by HDAC Inhibitors
    Derek Daigle, Cynthia M. Megyola, Ayman S. El-Guindy, Lyn Gradoville, David P. Tuck, George Miller, Sumita Bhaduri‐McIntosh · 2009 · Journal of Virology
  31. Lack of toxicity of a STAT3 decoy oligonucleotide
    Sen, Malabika, Tosca, Patricia J., Zwayer, Christa, Ryan, Michael J., Johnson, Jerry D., Knostman, Katherine A. B., Giclas, Patricia C., Peggins, James O., Tomaszewski, Joseph E., McMurray, Timothy P. et al. · 2009 · Cancer Chemotherapy and Pharmacology
  32. Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules
    Thorsten Berg · 2008 · ChemBioChem
  33. WT1 Promotes Cell Proliferation in Non-Small Cell Lung Cancer Cell Lines through Up-Regulating Cyclin D1 and p-pRb In Vitro and In Vivo
    Caihua Xu, Chen Hsuan Wu, Yang Xia, Zhaopeng Zhong, Xiang Liu, Jing Xu, Fei Cui, Bin Chen, Oluf Dimitri Røe, Aihong Li et al. · 2013 · PLoS ONE
  34. Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules
    Steven Fletcher, Brent D. G. Page, Xiaolei Zhang, Peibin Yue, Zhi Hua Li, Sumaiya Sharmeen, Jagdeep Singh, Wei Ming Zhao, Aaron David Schimmer, Suzanne Trudel et al. · 2011 · ChemMedChem
  35. Targeting Protein–Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small‐Molecule, Nonpeptidic SH2 Domain Binders
    Patrick Thomas Gunning, Matthew P. Glenn, Khandaker Siddiquee, William P. Katt, Eric Masson, Saı̈d M. Sebti, James Turkson, Andrew D. Hamilton · 2008 · ChemBioChem
  36. Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis
    Bo Kong, Yan Zhu, Guodong Li, Jessica A. R. Williams, Kyle Buckley, Ossama William Tawfik, James P. Luyendyk, Grace Liejun Guo · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  37. Ruxolitinib synergistically enhances the anti-tumor activity of paclitaxel in human ovarian cancer
    Ernest Soyoung Han, Wei Xiong Wen, Thanh Hue Dellinger, Jun Wu, Selena A. Lu, Richard Jove, John Hosei Yim · 2018 · Oncotarget
  38. Signal Transducer and Activator of Transcription Protein 3 (STAT3): An Update on its Direct Inhibitors as Promising Anticancer Agents
    Arianna Gelain, Matteo Mori, Fiorella Meneghetti, Stefania Villa · 2018 · Current Medicinal Chemistry
  39. Regression of Established Hepatocellular Carcinoma Is Induced by Chemoimmunotherapy in An Orthotopic Murine Model
    Diego M. Avella, Guangfu Li, Todd D. Schell, Dai Liu, Samuel Shao-Min Zhang, Xi Lou, Arthur S Berg, Eric T. Kimchi, Hephzibah Rani S. Tagaram, Qing X. Yang et al. · 2011 · Hepatology
  40. The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition
    Xiaofei Wang, Yan Zhang, XIWEN ZHANG, Wenxia Tian, Wenli Feng, Tingmei Chen · 2011 · International Journal of Oncology
  41. Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein–Tyrosine Phosphatase PTPN6
    Shujie Hou, Yong Weon Yi, Hyo Jin Kang, Li Zhang, Hee Jeong Kim, Yali Kong, Yong Liu, Kan Wang, Hyesik Kong, Scott C. Grindrod et al. · 2014 · Journal of Medicinal Chemistry
  42. STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis
    Ying Dunkel, Andrew Ong, Dimple Notani, Yash Mittal, Michael T. Y. Lam, Xiaoyi Mi, Pradipta Ghosh · 2012 · Journal of Biological Chemistry
  43. Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
    Soudeh Ghafouri‐Fard, Vahid Kholghi Oskooei, Iman Azari, Mohammad Naser Taheri · 2018 · World Journal of Surgical Oncology
  44. Mechanisms of the Anticancer Effects of Isothiocyanates
    Neel Manoj Fofaria, Alok Ranjan, Sung‐Hoon Kim, Sanjay Srivastava · 2015 · The Enzymes
  45. Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules
    Wenda Zhang, Ting Ma, Shanshan Li, Yanwei Yang, Jianpeng Guo, Wenying Yu, Lingyi Kong · 2016 · European Journal of Medicinal Chemistry
  46. Dysregulated Expression of RPS4Y1 (Ribosomal Protein S4, Y-Linked 1) Impairs STAT3 (Signal Transducer and Activator of Transcription 3) Signaling to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia
    Xuehai Chen, Chao Tong, Haiying Li, Wei Peng, Rong Li, Xin Luo, Huisheng Ge, Yuxin Ran, Li Qin, Yamin Liu et al. · 2018 · Hypertension
  47. Wilms' Tumor 1 and Signal Transducers and Activators of Transcription 3 Synergistically Promote Cell Proliferation: A Possible Mechanism in Sporadic Wilms' Tumor
    Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang, Xin-Yuan Fu · 2006 · Cancer Research
  48. HDACi: molecular mechanisms and therapeutic implications in the innate immune system
    Bandar A. Suliman, Dakang Xu, Bryan R.G. Williams · 2011 · Immunology and Cell Biology
  49. Inhibition of the Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway by 4-Oxo-1-Phenyl-1,4-Dihydroquinoline-3-Carboxylic Acid Esters
    Jun Xu, Derek C. Cole, Chao-Pei Betty Chang, Ramzi Ayyad, Magda Asselin, Wenshan Hao, James J. Gibbons, Scott A. Jelinsky, Kathryn A. Saraf, Kaapjoo Park · 2008 · Journal of Medicinal Chemistry
  50. Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors
    Christine Brotherton‐Pleiss, Peibin Yue, Yinsong Zhu, Kayo Nakamura, Weiliang Chen, Wen‐Zhen Fu, Casie S. Kubota, Jasmine Chen, Felix Alonso-Valenteen, Simoun Mikhael et al. · 2020 · Journal of Medicinal Chemistry
  51. Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells
    Lin · 2010 · International Journal of Oncology
  52. Functions of the Drosophila JAK-STAT pathway
    Marc Amoyel, Erika A Bach · 2012 · JAK-STAT
  53. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
    Ju‐Hee Kang, Yeong‐Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun Oh · 2019 · Laboratory Animal Research
  54. Stat3: Linking inflammation to (gastrointestinal) tumourigenesis
    Matthias Ernst, Tracy L. Putoczki · 2011 · Clinical and Experimental Pharmacology and Physiology
  55. Therapeutic Potency of Nanoformulations of siRNAs and shRNAs in Animal Models of Cancers
    Md. Emranul Karim, Kyi Kyi Tha, Iekhsan Othman, Mohammad Borhan Uddin, Ezharul Hoque Chowdhury · 2018 · Pharmaceutics
  56. Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer
    Junhong Zhao, Yujuan Dong, Wei Kang, Minnie Y.Y. Go, JOANNA H.M. TONG, Enders K. Ng, Philip Wai Yan Chiu, Alfred S.L. Cheng, Ka Fai To, Joseph J.�Y. Sung et al. · 2014 · Oncoscience
  57. Anaplastic Lymphoma Kinase (ALK)-Induced Malignancies: Novel Mechanisms of Cell Transformation and Potential Therapeutic Approaches
    Mariusz A. Wasik, Qian Zhang, Michał Marzec, Monika Kasprzycka, Hong Yi Wang, Xiaobin Liu · 2009 · Seminars in Oncology
  58. Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects
    Malabika Sen, Kathleen C. Paul, Maria L. Freilino, Hua Li, Changyou Li, Daniel E. Johnson, Lin Wang, Julie L. Eiseman, Jennifer Rubin Grandis · 2013 · Molecular Medicine
  59. Enhanced Sensitivity of Pancreatic Cancer Cells to Concurrent Inhibition of Aberrant Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor or Src
    Soumya Jaganathan, Peibin Yue, James Turkson · 2010 · Journal of Pharmacology and Experimental Therapeutics
  60. Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions
    Rajamanikkam Kamaraj, Subhrojyoti Ghosh, Souvadra Das, Shinjini Sen, Priyanka R. Kumar, Madhurima Majumdar, Renesa Dasgupta, Sampurna Mukherjee, Shrimanti Das, Indrilla Ghose et al. · 2024 · Bioconjugate Chemistry
  61. IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells
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  62. Subcellular Mislocalization of Mutant Hepatitis B X Proteins Contributes to Modulation of STAT/SOCS Signaling in Hepatocellular Carcinoma
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  63. Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids
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  64. Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy
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  65. Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges
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  66. Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia
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  88. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells
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  89. Dichotomies in cancer research: some suggestions for a new synthesis
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  90. STAT3 expression is associated with poor survival in non-elderly adult patients with newly diagnosed multiple myeloma
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  92. Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin
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  93. Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway
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  94. Effective down‐regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexes of siRNA and lipid‐substituted polyethyleneimine for sensitization of breast tumor cells to conventional chemotherapy
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  96. Prevention of Hypovolemic Circulatory Collapse by IL-6 Activated Stat3
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  98. All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin Carcinogenesis
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