The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Validating Stat3 in cancer therapy
Overview
Integrity signals
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Claims the paper makes
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is especially the case in over 95% of patients with head and neck squamous cell carcinoma (HNSCC) and 57.4% of patients with colorectal cancer (CRC) (3–5).”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [5]
Citations
Cites
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma
Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K., Shapiro, D. N., Saltman, D. L., & Look, A. T. (1994) · Science · doi:10.1126/science.8122112 · Cited by 2,428
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194
Yoshikawa, H., Matsubara, K., Qian, G.-S., Jackson, P. E., Groopman, J. D., Manning, J. E., Harris, C. C., & Herman, J. G. (2001) · Nature Genetics · doi:10.1038/ng0501-29 · Cited by 724
Song, H., Wang, R., Wang, S., & Lin, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409894102 · Cited by 504
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
Chiarle, R., Simmons, W. J., Cai, H., Dhall, G., Zamò, A., Raz, R., Karras, J. G., Levy, D. E., & Inghirami, G. (2005) · Nature Medicine · doi:10.1038/nm1249 · Cited by 441
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A. Y., Costello, J. F., McCormick, F., & Jablons, D. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232790100 · Cited by 380
Chan, K. S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J., & DiGiovanni, J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21032 · Cited by 355
Research works printed but not linked: 3
- Chan, K.S. J. Clin. Invest. 114, 720–728 (2004). · DOI
- Yoshikawa, H. et al. Nat. Genet. 28, 29–35 (2001).
- Sun, J. et al. Oncogene 24, 1–10 (2005).
Cited by
Sorted by citations
Items 301–316 of 316
Yadav, R., Garg, K., Garg, S., & Kumar, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-13212-4.00007-6
Wolfraim, L. A., & Letterio, J. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_13
Macrophage-Related Interaction Pathways in Tumor Stroma
Gusenbauer, S. (2012) · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
Hong, C., Deng, G., Jiang, Z., Lu, Y., Wu, Q., Huang, C., Tang, J., Zhou, H., Liu, Q. R., Luo, X. Y., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08675-4
BindingDB (2022) · UC San Diego · doi:10.7270/q2z89h31
BindingDB Entry 50006060: Development of new
BindingDB (2020) · UC San Diego · doi:10.7270/q2q52skr
BindingDB Entry 50033058: Identification of a New Series of STAT3 Inhibitors by Virtual Screening.
BindingDB (2011) · UC San Diego · doi:10.7270/q2fj2h21
Metadata
- Authors
- Darnell, J. E.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Darnell, James E
- Venue
- Nature Medicine
- Published
- 2005-06
- Volume
- 11
- Issue
- 6
- Pages
- 595-596
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1977532256
- Cited by
- 307
- References
- 15
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 21 · 2017: 14 · 2016: 15 · 2015: 9 · 2014: 27 · 2013: 30 · 2012: 17
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Mechanisms and Therapy
- Keywords
- STAT3, transcription factors, cancer therapy, STAT3 inhibitor, therapeutic target, in vivo validation, anticancer agents
- MeSH terms
- Animals, Antineoplastic Agents, DNA-Binding Proteins, Humans, Neoplasm Proteins, Neoplasms, Trans-Activators, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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