mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Majumder, Pradip K, Febbo, Phillip G, Bikoff, Rachel, Berger, Raanan, Xue, Qi, McMahon, Louis M, Manola, Judith, Brugarolas, James +5 more·2004·Nature Medicine

Cited by (962)

Items 901–962 of 962

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  13. PTEN
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  22. Supplementary Figure 3 from MYC Activity Mitigates Response to Rapamycin in Prostate Cancer through Eukaryotic Initiation Factor 4E–Binding Protein 1–Mediated Inhibition of Autophagy
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  23. Supplementary Figure Legends 1-4, Methods from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers
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    Elena J. Edelman · 2008 · DukeSpace (Duke University)
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    Yakun Luo, Virginie Vlaeminck‐Guillem, Silvère Baron, Sarah Dallel, Chang Xian Zhang, Muriel Le Romancer · 2021 · Figshare
  38. Additional file 2 of MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin
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  44. Outils biologiques pour l'exploration des réponses cellulaires à l'hypoxie dans les tumeurs mammaires invasives.
    Abderrahim El Guerrab · 2011 · theses.fr (ABES)
  45. Amino acids regulate hepatic intermediary metabolism-related gene expression via mTORC1-dependent manner in rainbow trout (Oncorhynchus mykiss)
    Dai Weiwei · 2015
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  48. PGC-1α régule un programme onco-métabolique capable de réprimer l’agressivité du cancer de la prostate
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  49. Role of VDAC1 hypoxic form, VDAC1-∆C, in the expression of primary cilia and tumor progression
    Lucilla Fabbri · 2019 · theses.fr (ABES)
  50. Implication de la GTPase RagA dans l’activation et la polarisation de la réponse lymphocytaire T
    Mehdi Attia · 2017
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  56. Effect of PI3K-p110α Inhibitor Alpelisib in the Differentiation and Effector Functions of M-CSF and GM-CSF Macrophages
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  58. BindingDB Entry 50021279: Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors.
    BindingDB · 2009 · UC San Diego
  59. BindingDB Entry 50040848: Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors.
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  60. BindingDB Entry 50003811: (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
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  61. Mechanisms of NOTCH1 Mediated Leukemogenesis: A Dissertation
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