mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Majumder, Pradip K, Febbo, Phillip G, Bikoff, Rachel, Berger, Raanan, Xue, Qi, McMahon, Louis M, Manola, Judith, Brugarolas, James, McDonnell, Timothy J, Golub, Todd R, Loda, Massimo, Lane, Heidi A, Sellers, William R·2004·Nature Medicine

DOI 10.1038/nm1052

Cited by (962)

Items 501–600 of 962

GSK-3β regulates tumor growth and angiogenesis in human glioma cells
Peng Zhao, Qi Li, Zhumei Shi, Charlie Li, Lin Wang, Xue Liu, Chengfei Jiang, Xu Qian, Yongping You, Ning Liu et al. · 2015 · Oncotarget
Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas
Nirvana Sadaghianloo, Julie Contenti, Alan Dardik, Nathalie M. Mazure · 2019 · International Journal of Molecular Sciences
PI3K/Akt/FoxO pathway mediates glycolytic metabolism in HepG2 cells exposed to triclosan (TCS)
Jing An, Huixin He, Weiwei Yao, Yu Shang, Yun Jiang, Zhiqiang Yu · 2020 · Environment International
Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury
Wenjia Xie, Qingyun He, Yan Zhang, Xinxin Xu, Ping Wen, Hongdi Cao, Yang Zhou, Jing Luo, Junwei Yang, Lei Jiang · 2023 · Cell Death and Disease
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
Ying Cai, Qidi Wang, Zhidong Ling, DANIEL G. PIPELEERS, Paul J. McDermott, Mario Pende, Harry Heimberg, Mark Van de Casteele · 2008 · Biochemical Pharmacology
PTEN Deficiency Is Fully Penetrant for Prostate Adenocarcinoma in C57BL/6 Mice via mTOR-Dependent Growth
Jorge M. Blando, Melisa J. Portis, Fernando J. Benavides, Angela Alexander, Gordon Brent Mills, Bhuvanesh Dave, Claudio J. Conti, Jeri Kim, Cheryl Lyn Walker · 2009 · American Journal Of Pathology
Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
Debabrata Chowdhury, Hani Alrefai, Julio Alberto Landero Figueroa, Kathleen Candor, Aleksey Porollo, Roger A. Fecher, Senad Divanovic, George S. Deepe, Kavitha Subramanian Vignesh · 2019 · Cell Reports
The role of proliferation signal inhibitors in post-transplant malignancies
Álex Gutiérrez-Dalmau, Josep Maria Campistol · 2007 · Nephrology Dialysis Transplantation
A Phase I Study of Everolimus and Docetaxel in Patients With Castration-Resistant Prostate Cancer
Kevin Dale Courtney, Judith B. Manola, Aymen A. Elfiky, Robert W. Ross, William K. Oh, Jeffrey T. Yap, Annick D. Van den Abbeele, Christopher W. Ryan, Tomasz M. Beer, Massimo F. Loda et al. · 2014 · Clinical Genitourinary Cancer
Levels of p27 Sensitize to Dual PI3K/mTOR Inhibition
Misu Lee, Marily Theodoropoulou, Jochen Graw, Federico Roncaroli, Maria Chiara Zatelli, Natalia Simona Pellegata · 2011 · Molecular Cancer Therapeutics
Role of Glucose Metabolism Reprogramming in the Pathogenesis of Cholangiocarcinoma
Kishor Pant, Seth Richard, Estanislao Peixoto, Sergio A. Gradilone · 2020 · Frontiers in Medicine
Hypersensitivity of Ph-positive lymphoid cell lines to rapamycin: Possible clinical application of mTOR inhibitor
Chikara Hirase, Yasuhiro Maeda, Shunsuke Takai, Akihisa Kanamaru · 2008 · Leukemia Research
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells
Gabriella Marfè, Carla Di Stefano, Alessandra Gambacurta, Tiziana Ottone, Valentina Martini, Elisabetta Abruzzese, Luca Mologni, Paola Sinibaldi Vallebona, Paolo de Fabritiis, Carlo B Gambacorti-Passerini et al. · 2011 · Experimental Hematology
Angiogenin-Stimulated rRNA Transcription Is Essential for Initiation and Survival of AKT-Induced Prostate Intraepithelial Neoplasia
Soichiro Ibaragi, Norie Yoshioka, Hiroko Kishikawa, Jamie Katy Hu, Peter M. Sadow, Ming Li, Guo-fu Hu · 2009 · Molecular Cancer Research
The mTOR Pathway in Breast Cancer
Nancy E. Hynes, Anne Boulay · 2006 · Journal of Mammary Gland Biology and Neoplasia
Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft
Priya T. Bhola, Sutapa Banerjee, Joydeep Mukherjee, Anand Balasubramanium, Vedant Arun, Zia Karim, Kelly E. Burrell, Sidney E. Croul, David H. Gutmann, Abhijit Guha · 2009 · International Journal of Cancer
Aspirin-triggered resolvin D1 inhibits TGF-β1-induced EMT through the inhibition of the mTOR pathway by reducing the expression of PKM2 and is closely linked to oxidative stress
Yu Liu, Xiaolong Yuan, Wenhui Li, Qianqian Cao, Yusheng Shu · 2016 · International Journal of Molecular Medicine
Effect of Aromatase Inhibition on Functional Gene Modules in Estrogen Receptor–Positive Breast Cancer and Their Relationship with Antiproliferative Response
Qiong Gao, Neill Patani, Anita K. Dunbier, Zara F. Ghazoui, Marketa Zvelebil, Lesley‐Ann Martin, Mitch Dowsett · 2014 · Clinical Cancer Research
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer
Armina A. Kazi, Rabia Afzal Gilani, Amanda J. Schech, Saranya Chumsri, Gauri J. Sabnis, Preeti Shah, Olga G. Goloubeva, Shari S. Kronsberg, Angela Brodie · 2014 · Breast Cancer Research
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism
Dina Johar, Ahmed Osama Elmehrath, Rania M. Khalil, Mostafa Hamed Elberry, Samy Zaky, Samy A. Shalabi, Larry H. Bernstein · 2021 · BioFactors
Clinical activity of mammalian target of rapamycin inhibitors in solid tumors
Yesid Alvarado, Monica M Mita, Sushma Vemulapalli, Devalingam Mahalingam, Alain C. Mita · 2011 · Targeted Oncology
Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model
Michael R. Milam, Joseph Celestino, Weiguo Wu, Russell R. Broaddus, Kathleen M. Schmeler, Brian M. Slomovitz, Pamela T. Soliman, David Marc Gershenson, Hong Wang, Lora H. Ellenson et al. · 2007 · American Journal of Obstetrics and Gynecology
The Connectivity Map Links Iron Regulatory Protein-1–Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy-Δ12,14-Prostaglandin J2
Michael Zimmer, Justin Lamb, Benjamin L. Ebert, Mary C. Lynch, Christopher R. Neil, Emmett V. Schmidt, Todd R. Golub, Othon Iliopoulos · 2010 · Cancer Research
Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration
Carmen Rodrı́guez, Noelia Puente‐Moncada, Russel Joseph Reiter, Ana M. Sánchez‐Sánchez, Federico Herrera, Jezabel Rodríguez‐Blanco, Cristina Duarte‐Olivenza, María Turos‐Cabal, Isaac Antolı́n, Vanesa Martı́n · 2020 · Journal of Cellular Physiology
Can Systems Biology Understand Pathway Activation? Gene Expression Signatures as Surrogate Markers for Understanding the Complexity of Pathway Activation
Hiraku Itadani, Shinji Mizuarai, Hidehito Kotani · 2008 · Current Genomics
Methionine Sulfoximine Treatment and Carbon Starvation Elicit Snf1-independent Phosphorylation of the Transcription Activator Gln3 in Saccharomyces cerevisiae
Jennifer J. Tate, Rajendra Rai, Terrance Cooper · 2005 · Journal of Biological Chemistry
TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?
Greg M. Findlay, Laura S. Harrington, Richard F. Lamb · 2004 · Current Opinion in Genetics & Development
Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2
Kenichi Harada, Hideaki Miyake, Masafumi Kumano, M. Fujisawa · 2013 · British Journal of Cancer
Targeting Autophagy as a Strategy for Drug Discovery and Therapeutic Modulation
Lixia Gao, Catherine E. Jauregui, Yong Teng · 2017 · Future Medicinal Chemistry
Signalling pathways in prostate carcinogenesis: potentials for molecular-targeted therapy
Alison Ramsay, Hing Y. Leung · 2009 · Clinical Science
PTEN‐mediated pathways and their association with treatment‐resistant prostate cancer
Christopher C. Uzoh, Claire M. Perks, Amit K. Bahl, Jeff M.P. Holly, Marto Sugiono, Raj A. Persad · 2009 · British Journal of Urology
Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics
Minh Phuong Nguyen, Sangkyu Lee, You Mie Lee · 2013 · Archives of Pharmacal Research
Blood and Tissue Biomarkers in Prostate Cancer: State of the Art
Michelangelo Fiorentino, Elisa Capizzi, Massimo F. Loda · 2010 · Urologic Clinics of North America
Glycogen Synthase Kinase 3β Regulates Cell Death Induced by Synthetic Triterpenoids
Roberta Venè, Patrizia Larghero, Giuseppe Arena, Michael B. Sporn, Adriana Albini, Francesca Tosetti · 2008 · Cancer Research
Resistance to targeted treatment of gastroenteropancreatic neuroendocrine tumors
Matthias Beyens, Timon Vandamme, Marc Peeters, Guy Van Camp, Ken Op de Beeck · 2018 · Endocrine Related Cancer
mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells
Micol Silic‐Benussi, Evgenyia Sharova, Francesco Ciccarese, Ilaria Cavallari, Vittoria Raimondi, Loredana Urso, Alberto Corradin, Harel Kotler, Gloria Scattolin, Barbara Buldini et al. · 2022 · Redox Biology
Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer
Da-zhi Xu, Qi-rong Geng, Ying Tian, Mu-Yan Cai, Xin-juan Fang, You Qing Zhan, Zhi-Wei Zhou, Wei Li, Ying-bo Chen, Xiao Sun et al. · 2010 · BMC Cancer
Predictive biomarkers for the activity of mammalian target of rapamycin (mTOR) inhibitors
Catherine Delbaldo, Sébastien Albert, Chantal Dreyer, Marie‐Paule Sablin, Maria Serova, Éric Raymond, Sandrine J. Faivre · 2011 · Targeted Oncology
Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development
Sofia Lisanti, David S. Garlick, Kelly G. Bryant, Michele Tavecchio, Gordon Brent Mills, Yiling Lu, Andrew V. Kossenkov, Louise C. Showe, Lucia R. Languino, Dario C. Altieri · 2016 · Journal of Biological Chemistry
Calcineurin Inhibitor-Free Immunosuppression in Pediatric Renal Transplantation
Britta Höcker, Burkhard Tönshoff · 2010 · Pediatric Drugs
A MULTIVARIATE EXTENSION OF THE GENE SET ENRICHMENT ANALYSIS
Lev B. Klebanov, Galina V. Glazko, Peter Salzman, ANDREI YAKOVLEV, Yuanhui Xiao · 2007 · Journal of Bioinformatics and Computational Biology
Suppression of Viral Replication by Stress-Inducible GADD34 Protein via the Mammalian Serine/Threonine Protein Kinase mTOR Pathway
Kahori Minami, Yukihiro Tambe, Ryosuke Watanabe, Takahiro Isono, Masataka Haneda, Ken‐ichi Isobe, Toshiyuki Kobayashi, Okio Hino, Hidetoshi Okabe, Tokuhiro Chano et al. · 2007 · Journal of Virology
A Novel Substrate Mimetic Inhibitor of PKB/Akt Inhibits Prostate Cancer Tumor Growth in Mice by Blocking the PKB Pathway
Pninit Litman, Osnat Ohne, Shirly Ben-Yaakov, Liron Shemesh-Darvish, Tamar Yechezkel, Yosef Salitra, Shai Rubnov, Ilana Cohen, Hanoch Senderowitz, Dvora Kidron et al. · 2007 · Biochemistry
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
Joaquín Araos Henríquez, Jonathan Paul Sleeman, Boyan K. Garvalov · 2018 · Clinical & Experimental Metastasis
Targeting phosphoinositide 3-kinase signalling in lung cancer.
Anna Wojtalla, A. Arcaro · 2011 · Critical reviews in oncology/hematology
La voie de signalisation PI3K-AKT-mTOR : description, développement thérapeutique, résistances, marqueurs prédictifs/pronostiques et applications thérapeutiques en cancérologie
Thibault Brotelle, Jacques‐Olivier Bay · 2015 · Bulletin du Cancer
Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1
Heba A Alshaker, Qi Wang, Yoshiaki Kawano, Tawfiq Arafat, Torsten Böhler, Mathias H. Winkler, Colin Cooper, Dmitri Pchejetski · 2016 · Oncotarget
Chaperone-mediated autophagy substrate proteins in cancer
Ying Chun Tang, Xiongwen Wang, Zhan-Hua Liu, Yun-Ming Sun, Yuxin Tang, Dai-Han Zhou · 2017 · Oncotarget
Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer
Raj Shah, Suzie Chen · 2020 · Cancers
Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of β-parvin
Mariko Kimura, Takashi Murakami, Shinae Kizaka‐Kondoh, Masayuki Itoh, Keiji Yamamoto, Yukihiro Hojo, Makoto Takano, Kazuomi Kario, Kazuyuki Shimada, Eiji Kobayashi · 2010 · Journal of Cell Science
TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy
Samuel Peña‐Llopis, James Brugarolas · 2011 · Cell Cycle
Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies
Hannah F. Kyle, Kate F. Wickson, Jonathan Stott, George M. Burslem, Alexander L. Breeze, Christian Tiede, Darren Charles Tomlinson, Stuart L. Warriner, Adam S. Nelson, Andrew John Wilson et al. · 2015 · Molecular BioSystems
Targeting IκB Kinase β/NF-κB Signaling in Human Prostate Cancer by a Novel IκB Kinase β Inhibitor CmpdA
Yan-ting Yann Zhang, Rena G. Lapidus, Peiyan Liu, Eun Yong Choi, Samusi Adediran, Arif Hussain, Xinghuan Wang, Xuefeng Liu, Han C. Dan · 2016 · Molecular Cancer Therapeutics
Inhibition of Proliferation, Migration, and Invasion by Knockdown of Pyruvate Kinase-M2 (PKM2) in Ovarian Cancer SKOV3 and OVCAR3 Cells
Yi Miao, Meng Lü, Qin Yan, Shuangdi Li, You-Ji Feng · 2016 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · Retracted
Somatic alterations as the basis for resistance to targeted therapies
Brian G Blair, Alberto Bardelli, Ben Ho Park · 2013 · The Journal of Pathology
An overview of the mTOR pathway as a target in cancer therapy
Ryan D. Gentzler, Jessica Kaplan Altman, Leonidas C. Platanias · 2012 · Expert Opinion on Therapeutic Targets
A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease
Sara J. Holditch, Carolyn Nicole Brown, Daniel J. Atwood, Andrew M. Lombardi, Khoa N. Nguyen, Harrison W. Toll, Katharina Hopp, Charles L. Edelstein · 2019 · American Journal of Physiology-Renal Physiology
Rapamycin and tumor growth: mechanisms behind its anticancer activity
Gudrun E. Koehl, Hans Jürgen Schlitt, Edward Kenneth Geissler · 2005 · Transplantation Reviews
GCP‐mediated growth inhibition and apoptosis of prostate cancer cells via androgen receptor‐dependent and ‐independent mechanisms
Clifford G. Tepper, Ruth L. Vinall, Christopher B. Wee, Lingru Xue, Xu-Bao Shi, Rebekah A. Burich, Philip C. Mack, Ralph Devere White · 2007 · The Prostate
The Mammalian Target of Rapamycin Kinase and Tumor Growth Inhibition
Anne Boulay, Heidi A. Lane · 2007 · Springer eBooks
Cancer Prevention: Strong Science and Real Medicine
Scott Michael Lippman, Bernard Levin · 2005 · Journal of Clinical Oncology
The mTOR Signaling Pathway and mTOR Inhibitors in Cancer: Next-generation Inhibitors and Approaches
Murat Ihlamur, Buşra Akgül, Yağmur Zengin, Şenay Vural Korkut, Kübra Kelleci, Emrah Şefik Abamor · 2023 · Current Molecular Medicine
From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past
Mahdi Abdoli Shadbad, Khalil Hajiasgharzadeh, Afshin Derakhshani, Nicola Silvestris, Amir Baghbanzadeh, Vito Racanelli, Behzad Baradaran · 2021 · Frontiers in Immunology
Robust metabolic adaptation underlying tumor progression
Pedro Vizán, Sybille Mazurek, Marta Cascante · 2008 · Metabolomics
Everolimus combined with gefitinib in patients with metastatic castration‐resistant prostate cancer: Phase 1/2 results and signaling pathway implications
Dana E. Rathkopf, Steven M. Larson, Aseem Anand, Michael J. Morris, Susan F. Slovin, David R. Shaffer, Glenn Heller, Brett Stewart Carver, Neal X. Rosen, Howard I. Scher · 2015 · Cancer
Literature Lab: a method of automated literature interrogation to infer biology from microarray analysis
Phillip G. Febbo, Mike G Mulligan, David A Slonina, Kimberly Stegmaier, Dolores Di Vizio, Paul R Martinez, Massimo F. Loda, Stephen C Taylor · 2007 · BMC Genomics
Hypoxia‐inducible factor‐2α: effect on radiation sensitivity and differential regulation by an mTOR inhibitor
Rupal Satish Bhatt, Daniel M. Landis, Michael Zimmer, Joelle Torregrossa, Shaoyong Chen, Vikas P. Sukhatme, Othon Iliopoulos, Steve Balk, Glenn J. Bubley · 2008 · British Journal of Urology
From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development
Saveur-Michel Maira, Peter M. Finan, Carlos Garcı́a-Echeverrı́a · 2010 · Current topics in microbiology and immunology
Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis
Glen A. Bjerke, C-S Yang, Henry F. Frierson, Bryce M. Paschal, David Wotton · 2013 · Oncogene
Novel mechanism of reducing tumourigenesis: Upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition
Samy L. Habib, Balakuntalam S. Kasinath, Ruth Rector Arya, Sandra Vexler, Chakradhar Velagapudi · 2010 · European Journal of Cancer
The role of HIF in immunity
Daniel Philip Gale, Patrick Henry Maxwell · 2009 · The International Journal of Biochemistry & Cell Biology
PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
Katharine Ellwood‐Yen, Heike Keilhack, Kaiko Kunii, Brian M. Dolinski, Yamicia Connor, Kun Hu, Kumiko Nagashima, Erin O’Hare, Yusuf Erkul, Alessandra Di Bacco et al. · 2011 · Cancer Research
Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations
Shaina N. Porter, Andrew S. Cluster, Wei Yang, Kelsey A Busken, Riddhi M. Patel, Jiyeon Ryoo, Jeffrey A. Magee · 2016 · eLife
PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose
Sui Seng Tee, Jae Mo Park, Ralph E. Hurd, Kyle R. Brimacombe, Matthew B. Boxer, Tarik F. Massoud, Brian K. Rutt, Daniel M. Spielman · 2017 · Oncotarget
Phase 2 clinical trial of TORC1 inhibition with everolimus in men with metastatic castration-resistant prostate cancer
Daniel J. George, Susan Halabi, Patrick N Healy, Darius Jonasch, Monika Anand, Julia Rasmussen, Sarah Yenser Wood, Charles E. Spritzer, John F. Madden, Andrew J. Armstrong · 2019 · Urologic Oncology Seminars and Original Investigations
The role of VEGF in triple-negative breast cancer: where do we go from here?
Susan Faye Dent · 2009 · Annals of Oncology
The rapamycin-regulated gene expression signature determines prognosis for breast cancer
Argun Akçakanat, Li Zhang, Spiridon Tsavachidis, Funda Meric‐Bernstam · 2009 · Molecular Cancer
Making Progress through Molecular Attacks on Cancer
Charles L. Sawyers · 2005 · Cold Spring Harbor Symposia on Quantitative Biology
Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo
Jason J. Zoeller, Roderick Terry Bronson, Laura M. Selfors, Gordon Brent Mills, Joan S. Brugge · 2017 · npj Breast Cancer
Research and innovation in the development of everolimus for oncology
David Lebwohl, George Thomas, Heidi A. Lane, Terence O’Reilly, Bernard J. Escudier, James C. Yao, Marianne Pavel, David Neal Franz, William J. Berg, Jean‐François Baladi et al. · 2011 · Expert Opinion on Drug Discovery
Safety and Preliminary Efficacy Analysis of the mTOR Inhibitor Ridaforolimus in Patients With Taxane-Treated, Castration-Resistant Prostate Cancer
Robert John Amato, George Wilding, Glenn J. Bubley, John W. Loewy, Frank G. Haluska, Mitchell Eric Gross · 2012 · Clinical Genitourinary Cancer
Influence of Rictor and Raptor Expression of mTOR Signaling on Long-Term Outcomes of Patients with Hepatocellular Carcinoma
Masaki Kaibori, Nobuaki Shikata, Tatsuma Sakaguchi, Morihiko Ishizaki, Kosuke Matsui, Hiroya Iida, Yoshito Tanaka, Hirokazu Miki, Richi Nakatake, Tadayoshi Okumura et al. · 2014 · Digestive Diseases and Sciences
Honokiol inhibits hypoxia-inducible factor-1 pathway
Keng-Li Lan, Keng‐Hsin Lan, Meei‐Ling Sheu, Ming‐Yuan Chen, Yi-Sheng Shih, Fu-chih Hsu, Hong-Ming Wang, Ru‐Shi Liu, Sang-Hue Yen · 2011 · International Journal of Radiation Biology
Inhibiting PI3K as a therapeutic strategy against cancer
Luis G Paz-Ares, Carmen Blanco‐Aparicio, Rocio García‐Carbonero, Amancio Carnero · 2009 · Clinical & Translational Oncology
Downregulation of Angiogenin Transcript Levels and Inhibition of Colonic Carcinoma by Gum Arabic (Acacia senegal)
Omaima Nasir, Kan Wang, Michael Föller, Madhuri Bhandaru, Diana Sandulache, Ferruh Artunç, Teresa F. Ackermann, Ammar Mubark Ebrahim, Mònica Palmada, Karin Klingel et al. · 2010 · Nutrition and Cancer
PTEN loss and activation of K‐RAS and β‐catenin cooperate to accelerate prostate tumourigenesis
Matthew T Jefferies, Adam C Cox, Boris Y. Shorning, Valérie S. Méniel, David F R Griffiths, Howard Kynaston, Matthew John Smalley, Alan Richard Clarke · 2017 · The Journal of Pathology
Review: Castration-resistant prostate cancer: new science and therapeutic prospects
Joaquim Bellmunt B, William K. Oh · 2010 · Therapeutic Advances in Medical Oncology
Warburg meets non-coding RNAs: the emerging role of ncRNA in regulating the glucose metabolism of cancer cells
Chenxiao Yu, Jiao Xue, Wei Jian Zhu, Jiao Yang, Shuyu Zhang, Jianping Cao · 2014 · Tumor Biology
Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models
Rachel M. Squillace, DAVID MILLER, Scott Wardwell, Frank Wang, Tim Clackson, Victor M. Rivera · 2012 · International Journal of Oncology
Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF
Jianing Wang, Chunshu Yang, Xiaoyu Hou, Jingyi Xu, Yun Yang, Ling Qin, Pingting Yang · 2021 · Frontiers in Immunology
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.
S. Maira, P. Furet, F. Stauffer · 2009 · Future Medicinal Chemistry
Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in aPTEN-deficient mouse model of prostate cancer
Marco Antonio De Velasco, Motoyoshi Tanaka, Yutaka Yamamoto, Yuji Hatanaka, Hiroyuki Koike, Kazuto Nishio, Kazuhiro Yoshikawa, Hirotsugu Uemura · 2014 · Carcinogenesis
mTOR inhibition sensitizes gastric cancer to alkylating chemotherapy in vivo.
Daniel Cejka, Matthias Preusser, Thorsten Fuereder, Wolfgang Sieghart, Johannes M. Werzowa, Sabine Strommer, Volker Wacheck · 2008 · PubMed
Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo
Na-Shun Mengke, Bei Hu, Qianpeng Han, Yiyu Deng, Ming Fang, Di Xie, Ang Li, Hongke Zeng · 2016 · Molecular Medicine Reports
Down‐regulation of PKM 2 enhances anticancer efficiency of THP on bladder cancer
Qiongli Su, Ting Tao, Lei Tang, Jun Deng, Kwame Oteng Darko, Sichun Zhou, Mei Peng, Shanping He, Qing Zeng, Alex F. Chen et al. · 2018 · Journal of Cellular and Molecular Medicine
A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis
Yao Liu, Fanzheng Meng, Jiabei Wang, Mingyang Liu, Guangchao Yang, Ruipeng Song, Tongsen Zheng, Yingjian Liang, Shugeng Zhang, Dalong Yin et al. · 2019 · Clinical Cancer Research
Interplay between hypoxia inducible Factor-1 and mitochondria in cardiac diseases
Jeanne Mialet‐Perez, Elise Belaïdi · 2024 · Free Radical Biology and Medicine
Downregulation of 18F-FDG Uptake in PET as an Early Pharmacodynamic Effect in Treatment of Non–Small Cell Lung Cancer with the mTOR Inhibitor Everolimus
Lucia Nogová, Ronald Boellaard, Carsten Kobe, Nikie J. Hoetjes, Thomas Zander, Stefan Hubert Gross, Saša Dimitrijević, Theodore C. Pellas, Wolfgang Eschner, Katja Schmidt et al. · 2009 · Journal of Nuclear Medicine
Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors
Andrei G. Vlassenko, Jonathan McConathy, Lars E. Couture, Yi Su, Parinaz Massoumzadeh, Hayden Leeds, Michael R. Chicoine, David Dinh Tran, Jiayi Huang, Sonika M Dahiya et al. · 2015 · Disease Markers
Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1α inhibitors
Shanthaveerappa K. Boovanahalli, Xuejun Jin, Yinglan Jin, Jin Hwan Kim, Nguyễn Tiến Đạt, Young‐Soo Hong, Jeong Hyun Lee, Sang‐Hun Jung, Kyeong Lee, Jung Joon Lee · 2007 · Bioorganic & Medicinal Chemistry Letters