mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Majumder, Pradip K, Febbo, Phillip G, Bikoff, Rachel, Berger, Raanan, Xue, Qi, McMahon, Louis M, Manola, Judith, Brugarolas, James +5 more·2004·Nature Medicine
DOI 10.1038/nm1052
Cited by (962)
Items 401–500 of 962
- Hypoxia induces a phase transition within a kinase signaling network in cancer cellsWei Wei, Qihui Shi, F. Remacle, Lidong Qin, David B. Shackelford, Young Shik Shin, Paul S. Mischel, Raphael David Levine, James R. Heath · 2013 · Proceedings of the National Academy of Sciences
- Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cellsJun Ping Hu, Yangfan Nie, Shifeng Chen, Chunlin Xie, Qiwen Fan, Zhichang Wang, Baisheng Long, Guokai Yan, Qing Zhong, Xianghua Yan · 2017 · The International Journal of Biochemistry & Cell Biology
- Ti 3 C 2 T x MXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea OrganoidsZhong Zhang, Shan Gao, Yangnan Hu, Xin Chen, Cheng Cheng, Xiaolong Fu, Sha‐Sha Zhang, Xin‐Lin Wang, Yu‐Wei Che, Chen Zhang et al. · 2022 · Advanced Science
- A review of therapies for diabetic macular oedema and rationale for combination therapyWinfried M. K. Amoaku, Shay Saker, Elizabeth Anne Stewart · 2015 · Eye
- Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathwayBeat C. Bornhauser, Laura Bonapace, Dan Lindholm, Rodrigo M. Maza, Gunnar Cario, Martin Schrappe, Felix K Niggli, Beat W. Schäfer, Jean‐Pierre Bourquin · 2007 · Blood
- Rapamycin Inhibits Proliferation of Estrogen-Receptor-Positive Breast Cancer CellsSharon B. Chang, Penelope L. Miron, Alexander Miron, James Dirk Iglehart · 2006 · Journal of Surgical Research
- A Randomized, Dose-Escalation Study of Subconjunctival and Intravitreal Injections of Sirolimus in Patients with Diabetic Macular EdemaPravin U. Dugel, Mark Scott Blumenkranz, Julia A. Haller, George A. Williams, WAYNE A. SOLLEY, David M Kleinman, Joel Naor · 2011 · Ophthalmology
- AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway–Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase BJia Xu, Xufen Yu, Tiphaine C. Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin, Elias Stratikopoulos, Kaitlyn M. Cahuzac, Li Wang, Ling Xie et al. · 2021 · Cancer Discovery
- Everolimus (Certican) in renal transplantation: a review of clinical trial data, current usage, and future directionsJulio Pascual, Ioannis N Boletis, Josep Maria Campistol · 2006 · Transplantation Reviews
- Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formationSamira Alliouachene, Robyn L. Tuttle, Stéphanie Boumard, Thomas Lapointe, Sophie Bérissi, Stéphane Germain, Francis Jaubert, David Tosh, Morris J. Birnbaum, Mario Pende · 2008 · Journal of Clinical Investigation
- The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancerBodo Clemens Melnik, Swen Malte John, Pedro Carrera‐Bastos, Loren Cordain · 2012 · Nutrition & Metabolism
- Genetically engineered mouse models of prostate cancerMaxime Parisotto, Daniel METZGER · 2013 · Molecular Oncology
- A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in miceSang‐Hyun Lee, George Poulogiannis, Saumyadipta Pyne, Shidong Jia, Lihua Zou, Sabina Signoretti, Massimo F. Loda, Lewis C. Cantley, Thomas M. Roberts · 2010 · Proceedings of the National Academy of Sciences
- mTOR Mediates Survival Signals in Malignant Mesothelioma Grown as Tumor Fragment SpheroidsShannon M. Wilson, Dario Barbone, Tsung‐Ming Yang, David M. Jablons, Raphael Bueno, David J. Sugarbaker, Stephen L. Nishimura, Gavin J. Gordon, V. Courtney Broaddus · 2008 · American Journal of Respiratory Cell and Molecular Biology
- TORgeting oncogene addiction for cancer therapyAndrew Y. Choo, John Blenis · 2006 · Cancer Cell
- CCR Drug Updates: Sorafenib and Sunitinib in Renal Cell CarcinomaMark N. Stein, Keith T. Flaherty · 2007 · Clinical Cancer Research
- Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma – systematic review and meta‐analysisKenya Yamanaka, Marius Petrulionis, Shibo Lin, Chao Gao, Uwe Galli, Susanne Richter, Susanne Winkler, Philipp Houben, Daniel P. Schultze, Etsuro Hatano et al. · 2013 · Cancer Medicine
- EverolimusJens Hasskarl · 2014 · Recent results in cancer research/Recent Results in Cancer Research
- S6K1 Plays a Key Role in Glial TransformationJean L. Nakamura, Edna Garcia, Russell O. Pieper · 2008 · Cancer Research
- Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technologyDebora Fumagalli, Alexis Blanchet-Cohen, David N. Brown, Christine Desmedt, David Gacquer, Stefan Michiels, Françoise Rothé, Samira Majjaj, Roberto Salgado, Denis Larsimont et al. · 2014 · BMC Genomics
- Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancersDebora Fumagalli, Timothy Richard Wilson, Roberto Salgado, Xuyang Lu, Jianjun Yu, Carol Lynn O'Brien, K. Walter, L Huw, Carmen Criscitiello, I. Laïos et al. · 2016 · Annals of Oncology
- RAD001 (Everolimus) inhibits growth of prostate cancer in the bone and the inhibitory effects are increased by combination with docetaxel and zoledronic acidTodd Matthew Morgan, Tiffany E.M. Pitts, Ted S. Gross, Sandra L. Poliachik, Robert L. Vessella, Eva Corey · 2008 · The Prostate
- Emerging strategies to overcome the resistance to current mTOR inhibitors in renal cell carcinomaMatteo Santoni, Francesco Pantano, Consuelo Amantini, Massimo Nabissi, Alessandro Conti, Luciano Burattini, Alice Zoccoli, Rossana Berardi, Giorgio Santoni, Giuseppe Tonini et al. · 2014 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistanceWei‐Yu Chen, Yu‐Ching Wen, Shian‐Ren Lin, Hsiu-Lien Yeh, Kuo-Ching Jiang, Weihao Chen, Yow-Sien Lin, Qingfu Zhang, Phui‐Ly Liew, Michael Hsiao et al. · 2021 · Communications Biology
- Targeting mTOR for Anti-Aging and Anti-Cancer TherapyWencheng Fu, Geng Wu · 2023 · Molecules
- Frequent Gene Products and Molecular Pathways Altered in Prostate Cancer- and Metastasis-Initiating Cells and Their Progenies and Novel Promising Multitargeted TherapiesMurielle Mimeault, Surinder K. Batra · 2011 · Molecular Medicine
- Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.Mark R. Morris, David J. Hughes, Ya-Min Tian, Christopher J. Ricketts, Kah Weng Lau, Dean Gentle, Salwati Shuib, Pablo Serrano‐Fernández, Jan Lubiński, Michael Sean Wiesener et al. · 2009 · PubMed
- Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesisYing‐Ying Lee, Myth T.S. Mok, Wei Kang, Weiqin Yang, Wenshu Tang, Feng Wu, Liangliang Xu, Mingfei Yan, Zhuo Yu, Sau-Dan Lee et al. · 2018 · Nucleic Acids Research
- miR-142 controls metabolic reprogramming that regulates dendritic cell activationYaping Sun, Katherine I. Oravecz-Wilson, Sydney Bridges, Richard C. McEachin, Julia J. Wu, Stephanie H. Kim, Austin Taylor, Cynthia K. Zajac, Hideaki Fujiwara, Daniel Peltier et al. · 2019 · Journal of Clinical Investigation
- Metabolomic profiling for the identification of novel diagnostic markers and therapeutic targets in prostate cancer: an updateGiuseppe Tiziano Lucarelli, Davide Loizzo, Matteo Ferro, Monica Rutigliano, Mihai Dorin Vartolomei, Francesco Cantiello, Carlo Buonerba, Giuseppe Di Lorenzo, Daniela Terracciano, Ottavio DE COBELLI et al. · 2019 · Expert Review of Molecular Diagnostics
- Akt pathway as a target for therapeutic intervention in HNSCC.M Moral, Jesús María Paramio · 2008 · PubMed
- Proliferation Signal Inhibitors in Transplantation: Questions at the Cutting Edge of Everolimus TherapyJeremy Robert Chapman, Hannah A. Valantine, Joan Albanell, Wolfgang Arns, Josep Maria Campistol, Howard J. Eisen, Maria Frigerio, Hans Brendan Lehmkuhl, R. Marcén, Randall Ellis Morris et al. · 2007 · Transplantation Proceedings
- MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cellsMeysam Moghbeli · 2021 · Journal of Ovarian Research
- Evaluation of the Role of Hexokinase Type II in Cellular Proliferation and Apoptosis Using Human Hepatocellular Carcinoma Cell LinesKeun Jae Ahn, Hee Sung Hwang, Jeon Han Park, Seong-Hye Bang, Won Jun Kang, Mijin Yun, Jong Doo Lee · 2009 · Journal of Nuclear Medicine
- mTOR signaling in human cancerJoan Albanell, Alba Dalmases, Ana Rovira, Federico Rojo · 2007 · Clinical & Translational Oncology
- Isoflurane Preconditioning Decreases Myocardial Infarction in Rabbits via Up-regulation of Hypoxia Inducible Factor 1 That Is Mediated by Mammalian Target of RapamycinJacob Raphael, Zhiyi Zuo, Suzan Abedat, Rоnen Beeri, Yaacov Gozal · 2008 · Anesthesiology
- Pilot Study of Rapamycin in Patients with Hormone-Refractory Prostate CancerRobert John Amato, Jaroslaw Jac, Taqi Mohammad, Somyata Saxena · 2008 · Clinical Genitourinary Cancer
- Emerging Hallmarks of Metabolic Reprogramming in Prostate CancerFrancesco M. Lasorsa, Nicola Antonio di Meo, Monica Rutigliano, Matteo Ferro, Daniela Terracciano, Octavian Sabin Tătaru, Michele Battaglia, Pasquale Ditonno, Giuseppe Tiziano Lucarelli · 2023 · International Journal of Molecular Sciences
- Prostatic preneoplasia and beyondAnthony Michael Joshua, A. Evans, Theodorus van der Kwast, Maria Zieleńska, Alan Keith Meeker, Arul M. Chinnaiyan, Jeremy Andrew Squire · 2007 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen AvailabilityKarl Xaver Knaup, Katrin Jozefowski, Regina Schmidt, Wanja M. Bernhardt, Alexander Weidemann, Jan Steffen Jürgensen, Christina Warnecke, Kai‐Uwe Eckardt, Michael Sean Wiesener · 2009 · Molecular Cancer Research
- Postprandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signaling in rainbow trout (Oncorhynchus mykiss)Weiwei Dai, Stéphane Panserat, Jan Alexander Mennigen, Frédéric Terrier, Karine Dias, Iban Seiliez, Sandrine Cassy · 2013 · Journal of Experimental Biology
- The mammalian target of rapamycin signaling network and gene regulationGhada A. Soliman · 2005 · Current Opinion in Lipidology
- Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancerYulun Wu, Chaoran Jia, Wei Liu, Wei Zhan, Yao Chen, Junlin Lu, Yongli Bao, Shuyue Wang, Chunlei Yu, Lihua Zheng et al. · 2024 · Journal of Advanced Research
- KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1αXiaochen Li, Xiansheng Liu, Yongjian Xu, Jin Liu, Min Xie, Ni Wang, Shixin Chen · 2014 · International Journal of Oncology
- Dual Targeting of mTOR and Aurora-A Kinase for the Treatment of Uterine LeiomyosarcomaKari J. Brewer Savannah, Elizabeth G. Demicco, Kristelle Lusby, Markus PH. Ghadimi, Roman Belousov, Eric D. Young, Yiqun Zhang, Kai-Lieh Huang, Alexander J. Lazar, Kelly K. Hunt et al. · 2012 · Clinical Cancer Research
- Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BADYuria Saito, Yuko Tanaka, Yuichi Aita, Kiyo‐aki Ishii, Tatsuhiko Ikeda, Kazumasa Isobe, Yasushi Kawakami, Hitoshi Shimano, Hisato Hara, Kazuhiro Takekoshi · 2011 · American Journal of Physiology-Endocrinology and Metabolism
- Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1αXiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao et al. · 2019 · Frontiers in Pharmacology
- siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptakeThierry Galvez, Mary N. Teruel, Won Do Heo, Joshua Timothy Jones, Man Lyang Kim, Jen Liou, Jason W. Myers, Tobias Meyer · 2007 · Genome biology
- The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate CancerGoutam Chakraborty, Subhiksha Nandakumar, Rahim Hirani, Bastien Nguyen, Konrad Hermann Stopsack, Christoph K. Kreitzer, Sai Harisha Rajanala, Romina Ghale, Ying Zhang Mazzu, Nagavarakishore Pillarsetty et al. · 2022 · Clinical Cancer Research
- Targeting Aerobic Glycolysis and HIF-1α Expression Enhance Imiquimod-induced Apoptosis in Cancer CellsShi‐Wei Huang, Jun‐Kai Kao, Chun‐Ying Wu, Sin-Ting Wang, Hsin‐Chen Lee, Shu‐Mei Liang, Yi–Ju Chen, Jeng‐Jer Shieh · 2014 · Oncotarget
- Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesisZhimin Lu · 2011 · 癌症:英文版
- Targeting persistent androgen receptor signaling in castration-resistant prostate cancerLaura S Graham, Michael Thomas Schweizer · 2016 · Medical Oncology
- The Mammalian Target of Rapamycin Pathway as a Potential Target for Cancer ChemopreventionLevy Kopelovich, Judith R. Fay, Caroline C. Sigman, James A. Crowell · 2007 · Cancer Epidemiology Biomarkers & Prevention
- Somatic stem cells and the origin of cancerJose Angel Martinez-Climent, Enrique José Andreu, Felipe Prósper · 2006 · Clinical & Translational Oncology
- Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapyHiroaki Ikeda, Hideaki Kakeya · 2021 · The Journal of Antibiotics
- Rapamycin Partially Mimics the Anticancer Effects of Calorie Restriction in a Murine Model of Pancreatic CancerLaura M. Lashinger, Lauren M. Malone, Graham William Brown, Elizabeth A. Daniels, Jason A. Goldberg, Glen M. Otto, Susan M. Fischer, Stephen David Hursting · 2011 · Cancer Prevention Research
- PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibitionSamuel W. Brady, Jian Zhang, Ming-Horng Tsai, Dihua Yu · 2015 · Cancer Biology & Therapy
- RETRACTED: Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERαVincenzo Nicola Talesa, Ivana Ferri, Guido Bellezza, Harold D. Love, Angelo Sidoni, Cinzia Antognelli · 2016 · The Prostate · Retracted
- Noscapine inhibits hypoxia-mediated HIF-1α expression andangiogenesis in vitro: a novel function for an old drugElizabeth W. Newcomb, Yevgeniy Lukyanov, Tona Schnee, M. Ali, Lan Li, David Zagzag · 2006 · International Journal of Oncology
- Nutrient Sensing in CancerMargaret E. Torrence, Brendan D. Manning · 2017 · Annual Review of Cancer Biology
- Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutationsDavid James Pinato, Radha Ramachandran, S T K Toussi, Marco Vergine, N Ngo, Rohini Sharma, Tyler Lloyd, Karim M. Meeran, Fausto F Palazzo, N Martin et al. · 2012 · British Journal of Cancer
- A framework to identify physiological responses in microarray-based gene expression studies: selection and interpretation of biologically relevant genesWendy Rodenburg, A. Geert Heidema, Jolanda M.A. Boer, Ingeborg M. J. Bovee-Oudenhoven, Edith J. M. Feskens, Edwin C.M. Mariman, Jaap Keijer · 2007 · Physiological Genomics
- uPA/uPAR system activation drives a glycolytic phenotype in melanoma cellsAnna Laurenzana, Anastasia Chillà, Cristina Luciani, Silvia Peppicelli, Alessio Biagioni, Francesca Bianchini, Elena Tenedini, Eugenio Torre, Alessandra Mocali, Lido Calorini et al. · 2017 · International Journal of Cancer
- Precancer in Mice: Animal Models Used to Understand, Prevent, and Treat Human PrecancersRobert D. Cardiff, Miriam R. Anver, Gregory P. Boivin, Marcus Bosenberg, Robert R. Maronpot, Alfredo Molinolo, Alexander Yu. Nikitin, Jerold E. Rehg, GEORGE V. THOMAS, Robert G. Russell et al. · 2006 · Toxicologic Pathology
- RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolismWenke Wang, Bei Shi, Ruiting Cong, Mingjun Hao, Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Naijin Zhang, Da Li · 2022 · Cell Death Discovery
- The Role of External Beam Radiation and Targeted Therapy in Thyroid CancerJames D. Brierley, Eric Jeffrey Sherman · 2012 · Seminars in Radiation Oncology
- Targeted therapies in renal cell cancer: recent developments in imagingAstrid A.M. van der Veldt, Martijn Ruben Meijerink, Alfons J.M. van den Eertwegh, Epie Boven · 2010 · Targeted Oncology
- Metabolic changes in bladder cancerBenjamin Leeland Woolbright, Matthew Ayres, John Arthur Taylor · 2018 · Urologic Oncology Seminars and Original Investigations
- Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular DiseasesArun Samidurai, Rakesh C. Kukreja, Anindita Das · 2018 · Oxidative Medicine and Cellular Longevity
- A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translationSharmila Prabhu, D Saadat, Maggie Zhang, L Halbur, John P. Fruehauf, S. Tiong Ong · 2006 · Oncogene
- Novel dual-color immunohistochemical methods for detecting ERG–PTEN and ERG–SPINK1 status in prostate carcinomaRitu Bhalla, Lakshmi Priya Kunju, Scott A. Tomlins, Kelly Christopherson, Connie C. Cortez, Shannon L. Carskadon, Javed Siddiqui, Kyung Park, Juan Miguel Mosquera, Gary Anthony Pestano et al. · 2013 · Modern Pathology
- EGF receptor mutations in lung cancer: From humans to mice and maybe back to humansCarlos L. Arteaga · 2006 · Cancer Cell
- Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastomaMatthew Robert Womeldorff, David L. Gillespie, Randy L. Jensen · 2014 · Neurosurgical FOCUS
- Advances in mouse models of prostate cancerImran Ahmad, Owen James Sansom, Hing Y. Leung · 2008 · Expert Reviews in Molecular Medicine
- The pros and the cons of mTOR inhibitors in kidney transplantationClaudio E. Ponticelli · 2013 · Expert Review of Clinical Immunology
- Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cellsEsraah Sattar Alharris, Narendra Prasad Singh, Prakash S. Nagarkatti, Mitzi Nagarkatti · 2019 · Oncotarget
- Targeting hypoxia and angiogenesis through HIF-1alpha inhibitionJuan Antonio Díaz-González, James Russell, Ana Rouzaut, Ignacio Gil Bazo, Luis M. Montuenga · 2005 · Cancer Biology & Therapy
- The Tuberous Sclerosis Complex Regulates Trafficking of Glucose Transporters and Glucose UptakeXiuyun Jiang, Heidi L. Kenerson, Lauri D. Aicher, Robert S. Miyaoka, Janet F. Eary, John J. Bissler, Raymond S. W. Yeung · 2008 · American Journal Of Pathology
- Will PI3K pathway inhibitors be effective as single agents in patients with cancer?Joan T. Garrett, Anindita Chakrabarty, Carlos L. Arteaga · 2011 · Oncotarget
- Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein SynthesisXiaoxi Han, Shengkun Sun, Ming Zhao, Xiang Cheng, Guozhu Chen, Song Lin, Yifu Guan, Xiaodan Yu · 2014 · PLoS ONE
- NCCN Task Force Report: mTOR Inhibition in Solid TumorsRobert A. Figlin, Elizabeth Brown, Andrew J. Armstrong, Wallace Akerley, Al B. Benson, Harold J. Burstein, David S. Ettinger, Phillip G. Febbo, Matthew G. Fury, Gary R. Hudes et al. · 2008 · Journal of the National Comprehensive Cancer Network
- Transient mTOR Inhibition Facilitates Continuous Growth of Liver Tumors by Modulating the Maintenance of CD133+ Cell PopulationsZhaojuan Yang, Li Zhang, Aihui Ma, Lanlan Liu, Jinjun Li, Jianren Gu, Yongzhong Liu · 2011 · PLoS ONE
- Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer CellsYan Liu, Shi‐Yong Sun, Taofeek Kunle Owonikoko, Gabriel Sica, Walter John Curran, Fadlo Raja Khuri, Xingming Deng · 2011 · Molecular Cancer Therapeutics
- Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosisLei Zhan, Wenyan Wang, Yu Zhang, Enxue Song, Yijun Fan, Bing Wei · 2016 · Biochimie
- Oxidative stress and metabolic reprogramming in Cr(VI) carcinogenesisMarco Clementino, Xianglin Shi, Zhuo Zhang · 2017 · Current Opinion in Toxicology
- Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin‐resected hepatocellular carcinomaHideo Andreas Baba, Jeremias Wohlschlaeger, Vito Rosario Cicinnati, Philip a. Hilgard, Hauke Lang, Georgios Charalambos Sotiropoulos, Atsushi Takeda, Susanne Beckebaum, Klaus J. Schmitz · 2009 · Liver International
- Multiple Oncogenic Pathway Signatures Show Coordinate Expression Patterns in Human Prostate TumorsChad J. Creighton · 2008 · PLoS ONE
- mTOR inhibitors in pediatric kidney transplantationLars Pape, Thurid Ahlenstiel · 2013 · Pediatric Nephrology
- Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristicsBo Dai, Yun Yi Kong, Ding Wei Ye, Chun-guang Ma, Xiaoyan Zhou, Xu Yao · 2009 · British Journal of Urology
- Arsenic trioxide decreases AKT protein in a caspase-dependent mannerKoren Kathleen Mann, Myrian Colombo, Wilson H. Miller · 2008 · Molecular Cancer Therapeutics
- Nutrigenomic approaches for benefit-risk analysis of foods and food components: defining markers of healthRuan M. Elliott, Catalina Picó, Yvonne E.M. Dommels, Iwona Wybrańska, John E. Hesketh, Jaap Keijer · 2007 · British Journal Of Nutrition
- Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene statusNagata · 2010 · International Journal of Oncology
- Akt inhibitors: mechanism of action and implications for anticancer therapeuticsJaikrit Bhutani, Asfandyar Sheikh, Asfandyar Khan Niazi · 2013 · Infectious Agents and Cancer
- Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network AnalysisJingxu Yang, Hao Liu, Xiaorui Liu, Chengbo Gu, Ray Luo, Haifeng Chen · 2016 · Journal of Chemical Information and Modeling
- Th-POK regulates mammary gland lactation through mTOR-SREBP pathwayRui Zhang, Huimin Ma, Yuan Gao, Yanjun Wu, Yuemei Qiao, Ajun Geng, Cheguo Cai, Yingying Han, Yi Arial Zeng, Xiaolong Liu et al. · 2018 · PLoS Genetics
- Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addictionMarco Colombi, Klaus D. Molle, Don Benjamin, Karin F. Rattenbacher-Kiser, Christiane Schaefer, Charles Betz, Anke Thiemeyer, Urs Regenass, Michael N. Hall, Christoph Moroni · 2010 · Oncogene
- GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stressRyosuke Watanabe, Yukihiro Tambe, Hirokazu Inoue, Takahiro Isono, Masataka Haneda, Ken‐ichi Isobe, Toshiyuki Kobayashi, Okio Hino, Hidetoshi Okabe, Tokuhiro Chano · 2007 · International Journal of Molecular Medicine
- Hypoxia-inducible factors and cancerMaría José Calzada, Luis del Peso · 2007 · Clinical & Translational Oncology
- Hedgehog inhibitor decreases chemosensitivity to 5‐fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancerHideya Onishi, Yoshihiro Morifuji, Masaya Kai, Kumi Suyama, Hironori Iwasaki, Mitsuo Katano · 2012 · Cancer Science
- Modeling prostate cancer: a perspective on transgenic mouse modelsVarinder Jeet, Pamela Joan Russell, Aparajita Khatri · 2010 · Cancer and Metastasis Reviews