Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

Trautmann, Lydie, Janbazian, Loury, Chomont, Nicolas, Said, Elias A, Gimmig, Sylvain, Bessette, Benoit, Boulassel, Mohamed-Rachid, Delwart, Eric, Sepulveda, Homero, Balderas, Robert S, Routy, Jean-Pierre, Haddad, Elias K, Sekaly, Rafick-Pierre·2006·Nature Medicine

DOI 10.1038/nm1482

Cited by (1,001)

Items 801–900 of 1,001

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Yohann White, R B Pierre, J Steel-Duncan, P Palmer, Tracy Evans-Gilbert, J Moore, B Rodriguez, C D C Christie · 2008 · PubMed
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Mahsa Mohammadi, Maryam Akhoundi, Sara Malih, Ali Mohammadi, Mohsen Sheykhhasan · 2022 · Reviews in Medical Virology
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Adel Benlahrech, A Yasmin, Samantha J. Westrop, A Coleman, Anna Herasimtschuk, Emma E. Page, Peter Kelleher, F Gotch, Nesrina Imami, Steven Patterson · 2012 · Clinical & Experimental Immunology
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Simone Gonçalves Fonseca, Francesco A. Procopio, Jean-Philippe Goulet, Bader Yassine‐Diab, Petronela Ancuța, Rafick‐Pierre Sékaly · 2011 · Current Opinion in HIV and AIDS
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Björn Corleis, Josalyn L. Cho, Samantha J. Gates, Alice H. Linder, Amy K. Dickey, Antonella C. Lisanti-Park, Abigail E. Schiff, Musie S Ghebremichael, Puja Kohli, Tilo Winkler et al. · 2021 · American Journal of Respiratory Cell and Molecular Biology
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Wen Xiao, Long Feng Jiang, Xiao Zhao Deng, Dan Yan Zhu, Jia Ping Pei, Mao Lei Xu, Bing Jun Li, Chang Jun Wang, Jing Hai Zhang, Qi Zhang et al. · 2015 · Immunologic Research
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Wei Li, Fahim Syed, Richard Yu, Jing Yang, Ying Xia, Ryan F. Relich, Patrick M. Russell, Shanxiang Zhang, Mandana Khalili, Laurence Huang et al. · 2022 · Frontiers in Immunology
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Bernard J. C. Macatangay, Charles R. Rinaldo · 2009 · PubMed
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Cortez McBerry, Alexandra Dias, Nathaniel Shryock, Kristin Lampe, Fredy R. S. Gutierrez, Louis Boon, De’Broski R. Herbert, Júlio Aliberti · 2013 · European Journal of Immunology
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Lijun Xiao, Dimin Wang, Caijun Sun, Pingchao Li, Yi Jin, Liqiang Feng, Ling Chen · 2013 · Human Vaccines & Immunotherapeutics
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Jacob D. Estes, Roger Le Grand, Constantinos Petrovas · 2018 · Frontiers in Immunology
Checkpoint inhibitors for the treatment of JC virus-related progressive multifocal leukoencephalopathy
Erin Beck, Irene C. M. Cortese · 2020 · Current Opinion in Virology
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Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani · 2022 · Cancer Immunology Immunotherapy
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Michael A. Eller, Marc Sam Opollo, Michelle Liu, Andrew D. Redd, Leigh Anne Eller, Cissy M Kityo, John Timothy Kayiwa, Oliver B Laeyendecker, Maria Joan Wawer, M. Milazzo et al. · 2014 · The Journal of Infectious Diseases
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Chun‐Pu Lin, Pierre L. Levy, Astrid Alflen, Georgi Apriamashvili, Maarten Alexander Ligtenberg, David W. Vredevoogd, Onno B. Bleijerveld, Ferhat Alkan, Yuval Malka, Liesbeth Hoekman et al. · 2024 · Cancer Cell
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Chin-King Looi, Lian Chee Foong, Felicia Fei‐Lei Chung, Alan Soo Beng Khoo, Ee-Mun Loo, Chee‐Onn Leong, Chun‐Wai Mai · 2023 · Cell Biology and Toxicology
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M Papadakis, Ioannis Karniadakis, Nikolaos Mazonakis, Karolina Akinosoglou, Constantinos Tsioutis, Nikolaos A. Spernovasilis · 2023 · In Vivo
HCV-core and NS3 antigens play disparate role in inducing regulatory or effector T cells in vivo: Implications for viral persistence or clearance
Deepa Kolaseri Krishnadas, Wen Li, Rakesh K. Kumar, D. Lorne Tyrrell, Babita Agrawal · 2009 · Vaccine
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Chi Ngai Chan, Isabelle Dietrich, Margaret J. Hosie, Brian J. Willett · 2013 · Journal of General Virology
Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
Victor Appay, María Candela Iglesias · 2011 · Current Opinion in HIV and AIDS
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Egle Ramelyte, Sabrina A. Hogan, Reinhard Dummer · 2016 · Expert Opinion on Drug Safety
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Antonio Marra, Giosuè Scognamiglio, Ilaria Peluso, Gerardo Botti, Celeste Fusciello, Amelia Filippelli, Paolo A. Ascierto, Stefano Pepe, Francesco Sabbatino · 2017 · The Open AIDS Journal
Therapeutic HIV-1 vaccine
Nabila Seddiki, Yves Lévy · 2018 · Current Opinion in HIV and AIDS
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Richard Brad Jones, FengYun Yue, Xiao Xiao Jenny Gu, Diana V. Hunter, Shariq Mujib, Gabor T. Gyenes, Rosemarie D. Mason, Ruqaya Mohamed, Kelly S. MacDonald, Colin M Kovacs et al. · 2009 · Journal of Virology
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Henry Radziewicz, Holly L. Hanson, Rafi Ahmed, Arash Grakoui · 2008 · Gastroenterology
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Tioka, Louis, Diez, Rafael Ceña, Sönnerborg, Anders, van de Klundert, Maarten · 2025 · Pathogens
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Andrea Gramatica, Itzayana G. Miller, Adam R. Ward, Khan Farzana, Tyler J. Kemmer, Jared Weiler, Tan Thinh Huynh, Paul Zumbo, Andrew P. Kurland, Louise Leyre et al. · 2025 · Cell Reports
Implications of Senescent T Cells for Cancer Immunotherapy
Tetsuhiro Kasamatsu · 2023 · Cancers
Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody
Mengmeng Ji, J L Hu, Doudou Zhang, Bilian Huang, Shijie Xu, Na Jiang, Yuxin Chen, Yujiong Wang, Xilin Wu, Zhiwei Wu · 2024 · EMBO Molecular Medicine
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Rajeev Kumar Shrimali, John Edward Janik, Rasha Abu Eid, Mikayel Mkrtichyan, Samir N. Khleif · 2015 · Immunotherapy
Rapid downregulation of programmed death‐1 and interferon‐γ‐inducible protein‐10 expression is associated with favourable outcome during antiviral treatment of chronic hepatitis B
Feng-Qin Hou, Xuejie Wu, Y. Wang, J. Chen, Y.‐Z. Liu, Yuanyuan Ren, Ge Song, Yuping Ding, Ming‐Whei Yu, G.‐Q. Wang · 2013 · Journal of Viral Hepatitis
PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia
Rita Tendeiro Rego, Russell B. Foxall, António P. Baptista, Francisco Rodrigues Pinto, Rui Silva Soares, Rita Cavaleiro, Emília Valadas, Perpétua Gómes, Rui M. M. Victorino, Ana E. Sousa · 2012 · AIDS
Immunotherapy of Murine Retrovirus-Induced Acquired Immunodeficiency by CD4 T Regulatory Cell Depletion and PD-1 Blockade
Wen Li, William R. Green · 2011 · Journal of Virology
The HIV-1 Tat protein affects human CD4+ T-cell programing and activation, and favors the differentiation of naïve CD4+ T cells
Francesco Nicoli, Eleonora Gallerani, Fabio Sforza, Valentina Finessi, Mkunde Chachage, Christof Geldmacher, Aurelio Cafaro, Barbara Ensoli, Antonella Caputo, Riccardo Gavioli · 2017 · AIDS
Alveolar Macrophage Dysfunction and Increased PD-1 Expression During Chronic SIV Infection of Rhesus Macaques
Ruth Hunegnaw, Zuena Mushtaq, Gospel M Enyindah-Asonye, Tanya N. Hoang, Marjorie Robert-Guroff · 2019 · Frontiers in Immunology
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure
Selena Viganó, Sara Bobisse, George Coukos, Matthieu Perreau, Alexandre Harari · 2020 · Frontiers in Immunology
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Afam A. Okoye, Rémi Fromentin, Hiroshi Takata, Jessica H. Brehm, Yoshinori Fukazawa, Bryan E. Randall, Marion Pardons, Vincent W.‐F. Tai, Jun Tang, Jeremy V Smedley et al. · 2022 · PLoS Pathogens
Finding Balance: T cell Regulatory Receptor Expression during Aging.
Mary Cavanagh, Qian Qi, Cornelia M. Weyand, Jörg J. Goronzy · 2011 · Europe PMC (PubMed Central)
Impact of γ‐chain cytokines on T cell homeostasis in HIV‐1 infection: therapeutic implications
Marie‐Lise Gougeon, Francesca Chiodi · 2010 · Journal of Internal Medicine
Analysis of peripheral blood dendritic cells as a non-invasive tool in the follow-up of patients with chronic hepatitis C
Andrea Crosignani · 2016 · World Journal of Gastroenterology
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Christian Deo T. Deguit, Michelle Hough, Rebecca Hoh, Melissa Krone, Christopher D. Pilcher, Jeffrey N. Martin, Steven G. Deeks, J M McCune, Peter W. Hunt, Rachel Lena Rutishauser · 2019 · JAIDS Journal of Acquired Immune Deficiency Syndromes
Preclinical Evaluation of HIV Eradication Strategies in the Simian Immunodeficiency Virus-Infected Rhesus Macaque: A Pilot Study Testing Inhibition of Indoleamine 2,3-Dioxygenase
Richard M. Dunham, Shari N. Gordon, Monica Vaccari, Michael Piatak, Yong Huang, Steven G. Deeks, Jeffrey D. Lifson, Genoveffa Franchini, J M McCune · 2012 · AIDS Research and Human Retroviruses
Dysfunctional State of T Cells or Exhaustion During Chronic Viral Infections and COVID-19: A Review
K.P. Mishra, Mrinalini Singh, Deepika Saraswat, Lilly Ganju, Rajeev Kumar Varshney · 2022 · Viral Immunology
Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo
Hanyu Pan, Xinyi Yang, Jing Wang, Huitong Liang, Zhengtao Jiang, Lin Zhao, Yanan Wang, Zhiming Liang, Xiaoting Shen, Qinru Lin et al. · 2023 · Virologica Sinica
Interleukin‐10‐secreting T cells define a suppressive subset within the HIV‐1‐specific T‐cell population
Eirik A. Torheim, Lishomwa C. Ndhlovu, Frank Olav Pettersen, Trine‐Lise Larsen, Aashish R. Jha, Knut Martin Torgersen, Dag Kvale, Douglas F. Nixon, Kjetil Taskén, Einar Martin Aandahl · 2009 · European Journal of Immunology
CD4 + T cell–dependent and CD4 + T cell–independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals
Kelly B. Arnold, Gregory Lee Szeto, Galit Alter, Darrell J. Irvine, Douglas A. Lauffenburger · 2015 · Science Signaling
Clinical Interventions in HIV Cure Research
Thomas A. Rasmussen, Ole Schmeltz Søgaard · 2018 · Advances in experimental medicine and biology
Assessment of TCR signal strength of antigen-specific memory CD8+ T cells in human blood
Hanchih Wu, Ashley Witzl, Hideki Ueno · 2019 · Blood Advances