Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Uyttenhove, Catherine, Pilotte, Luc, Théate, Ivan, Stroobant, Vincent, Colau, Didier, Parmentier, Nicolas, Boon, Thierry, Van den Eynde, Benoît J·2003·Nature Medicine
DOI 10.1038/nm934
Cited by (1,003)
Items 601–700 of 1,003
- Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogationVladimir Wischnewski, Roeltje R. Maas, Paola Guerrero Aruffo, Klara Soukup, Giovanni Galletti, Mara Kornete, Sabine Galland, Nadine Fournier, Johanna Lilja, Pratyaksha Wirapati et al. · 2023 · Nature Cancer
- Towards a Genetic Definition of Cancer-Associated InflammationGeorge C. Prendergast, Richard A. Metz, Alexander J. Muller · 2010 · American Journal Of Pathology
- Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain TumorsCarlos Eduardo Alves Batista, Csaba Juhász, Otto Muzik, William J. Kupsky, Geoffrey R. Barger, Harry T. Chugani, Sandeep Mittal, Sandeep Sood, Pulak K. Chakraborty, Diane C. Chugani · 2009 · Molecular Imaging and Biology
- Rational combinations of immunotherapeutics that target discrete pathwaysStefani Spranger, Thomas Frank Gajewski · 2013 · Journal for ImmunoTherapy of Cancer
- Prognostic value of tumor infiltrating lymphocyte subsets in breast cancer depends on hormone receptor statusYul Ri Chung, Hyun Jeong Kim, Min Hye Jang, So Yeon Park · 2016 · Breast Cancer Research and Treatment
- Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the FuelMelita B. Irving, Romain Vuillefroy de Silly, Kirsten B. J. Scholten, Nahzli Dilek, George Coukos · 2017 · Frontiers in Immunology
- Cancer vaccines 2004 opening address: the molecular and cellular basis of cancer immunosurveillance and immunoediting.Krassimira O. Todorova, Irena Ignatova, Stoyan Tchakarov, Iskra Altankova, Serguei Zoubak, Stanimir Kyurkchiev, Milcho S. Mincheff · 2005 · PubMed
- Research Progress of Indoleamine 2,3-Dioxygenase InhibitorsTianze Jiang, Yingying Sun, Zhichao Yin, Sen Feng, Li‐Ping Sun, Zhiyu Li · 2015 · Future Medicinal Chemistry
- The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative EmmonsiaJosé Fernando Muñoz, Gregory M. Gauthier, Christopher A. Desjardins, Juan Esteban Gallo, Jason W. Holder, Thomas D. Sullivan, Amber J. Marty, John Cherrington Carmen, Zehua Chen, Li Ding et al. · 2015 · PLoS Genetics
- TCR-engineered T cells to treat tumors: Seeing but not touching?Reno Debets, Emmanuel Donnadieu, Salem Chouaı̈b, George Coukos · 2016 · Seminars in Immunology
- Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted HostsCarter M. Suryadevara, Rupen R. Desai, Samuel Harrison Farber, Bryan D. Choi, Adam M. Swartz, Steven H. Shen, Patrick C. Gedeon, David J. Snyder, James E. Herndon, Patrick N Healy et al. · 2018 · Clinical Cancer Research
- Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targetsAna Dolšak, Stanislav Gobec, Matej Sova · 2020 · Pharmacology & Therapeutics
- The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironmentLunxu Li, Yu Tian · 2023 · Biomedicine & Pharmacotherapy
- Nanotechnology Reprogramming Metabolism for Enhanced Tumor ImmunotherapyYangkai Zhou, Jing Tang Yuan, Ke Xu, Shilin Li, Ying Liu · 2024 · ACS Nano
- In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donorsM. Jenny, Martin Klieber, Daniela Zaknun, Sebastian Schroecksnadel, Katharina Kurz, Maximilian Ledochowski, Harald Schennach, Dietmar Fuchs · 2010 · Inflammation Research
- Suppressive Influences in the Immune Response to CancerVincenzo Bronte, Simone Mocellin M. D · 2008 · Journal of Immunotherapy
- Molecular mechanisms involved in the adaptation to amino acid limitation in mammalsCédric Chaveroux, Sarah Lambert-Langlais, Yoan Chérasse, Julien Avérous, Laurent Parry, Valérie Carraro, Céline Jousse, Anne‐Catherine Maurin, Alain Bruhat, Pierre Fafournoux · 2010 · Biochimie
- Effector-phase tolerance: another mechanism of how cancer escapes antitumor immune responseAlan B. Frey, Ngozi R. Monu · 2006 · Journal of Leukocyte Biology
- Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapyDONGDONG WANG, Yasushi Saga, Hiroaki Mizukami, Naoto Sato, HIROAKI NONAKA, Hiroyuki Fujiwara, Yuji Takei, 静生 町田, Osamu Takikawa, Keiya Ozawa et al. · 2011 · International Journal of Oncology
- Hypoxia-inducible factor-2 is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancerXiang Xue, Yatrik Madhukar Shah · 2012 · Carcinogenesis
- Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyondShao Thing Teoh, Sophia Y. Lunt · 2017 · WIREs Systems Biology and Medicine
- The Human T Cell Response to Melanoma AntigensPedro J. Romero, Jean‐Charles Cerottini, Daniel E. Speiser · 2006 · Advances in immunology
- Next generation immune-checkpoints for cancer therapyChiara Donini, Lorenzo D’Ambrosio, Giovanni Grignani, Massimo Aglietta, Dario Sangiolo · 2018 · Journal of Thoracic Disease
- Metabolic regulation of the cancer-immunity cycleLuis F. Somarribas Patterson, Santosha Adipudi Vardhana · 2021 · Trends in Immunology
- Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenasesHajime Julie Yuasa, Helen J. Ball, Yuen Fern Ho, Christopher Austin, Camilla M. Whittington, Katherine Belov, Ghassan J. Maghzal, Lars Sommer Jermiin, Nicholas Henry Hunt · 2009 · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology
- High expression of indoleamine 2,3-dioxygenase gene in prostate cancerChantal Feder‐Mengus, Stephen Frederic Wyler, Tvrtko Hudolin, Robin Ruszat, Lukas Bubendorf, Alberto Chiarugi, Maria Gloria Pittelli, William P. Weber, Alexander Bachmann, Thomas C. Gasser et al. · 2008 · European Journal of Cancer
- A Spliced Antigenic Peptide Comprising a Single Spliced Amino Acid Is Produced in the Proteasome by Reverse Splicing of a Longer Peptide Fragment followed by TrimmingAlexandre Michaux, Pierre Larrieu, Vincent Stroobant, Jean‐François Fonteneau, Francine Jotereau, Benoit J. Van den Eynde, Agnès Moreau‐Aubry, Nathalie Vigneron · 2014 · The Journal of Immunology
- T Lymphocytes Restrain Spontaneous Metastases in Permanent DormancyIrene Romero, Cristina Garrido, Ignacio Algarra, Antonia Collado, Federico Garrido, Angel Miguel Garcia-Lora · 2014 · Cancer Research
- Serum Tryptophan and Kynurenine Concentrations as Parameters for Indoleamine 2,3-Dioxygenase Activity in Patients With Endometrial,Ovarian, and Vulvar CancerRenske A. de Jong, Hans W. Nijman, H. Marike Boezen, Marcel Volmer, Klaske A. ten Hoor, Jasper Krijnen, Ate G.J. van der Zee, Harry Hollema, Ido P. Kema · 2011 · International Journal of Gynecological Cancer
- The pancreatic cancer microenvironment: A true double agentLaleh Golkar Melstrom, Marcela d'Alincourt Salazar, Don J. Diamond · 2017 · Journal of Surgical Oncology
- Dual-Blockade Immune Checkpoint for Breast Cancer Treatment Based on a Tumor-Penetrating Peptide Assembling NanoparticleGuorui Li, Yuan Gao, Chunai Gong, Zhimin Han, Lei Qiang, Zongguang Tai, Jing Tian, Shen Gao · 2019 · ACS Applied Materials & Interfaces
- Activatable Semiconducting Polymer Pro‐nanomodulators for Deep‐Tissue Sono‐immunotherapy of Orthotopic Pancreatic CancerJingchao Li, Ningyue Yu, Dong Mei Cui, Jiaguo Huang, Yu Luo, Kanyi Pu · 2023 · Angewandte Chemie International Edition
- T cell dysfunction in cancer: Role of myeloid cells and tumor cells regulating amino acid availability and oxidative stressPaulo C. Rodrı́guez, Augusto C. Ochoa · 2005 · Seminars in Cancer Biology
- Structure–activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitorsQiang Huang, Maofa Zheng, Shuangshuang Yang, Chunxiang Kuang, Cun-Jing Yu, Qing Yang · 2011 · European Journal of Medicinal Chemistry
- Tryptophan degradation in women with breast cancer: a pilot studyDebra Lyon, Jeanne M. Walter, Angela Renee Starkweather, Christine M. Schubert, Nancy L. McCain · 2011 · BMC Research Notes
- Uveal melanoma expression of indoleamine 2,3-deoxygenase: Establishment of an immune privileged environment by tryptophan depletionPeter W. Chen, Jessamee Mellon, Elizabeth S. Mayhew, Shixuan Wang, Yu Guang He, Nick Hogan, Jérry Y. Niederkorn · 2007 · Experimental Eye Research
- Mechanisms of Local Immunoresistance in GliomaEmilia Albesiano, James E. Han, Michael K. Lim · 2009 · Neurosurgery Clinics of North America
- Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for ImmunoparalysisElisa Wirthgen, Andreas Hoeflich · 2015 · Journal of Amino Acids
- Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune EscapeSanmay Bandyopadhyay, Thomas J. Quinn, Lisa Scandiuzzi, Indranil Basu, Ari Partanen, Wolfgang A. Tomé, Fernando Macián, Chandan Guha · 2016 · The Journal of Immunology
- The mechanisms tumor cells utilize to evade the host's immune systemNyanbol Kuol, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos · 2017 · Maturitas
- Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint InhibitorsFlorence Schramme, Stefano Crosignani, Kim Frederix, Delia Hoffmann, Luc Pilotte, Vincent Stroobant, Julie Preillon, Grégory Driessens, Benoit J. Van den Eynde · 2019 · Cancer Immunology Research
- Role of tryptophan metabolism in cancers and therapeutic implicationsXiaohan Liu, Xiao‐Yue Zhai · 2021 · Biochimie
- Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host diseaseHolly A. Bolton, Erhua Zhu, Alexandra M. Terry, Thomas V. Guy, Woon‐Puay Koh, Sioh‐Yang Tan, Carl Andrew Power, Patrick Bertolino, Katharina Lahl, Tim D. Sparwasser et al. · 2015 · Journal of Clinical Investigation
- Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitorsUte F. Röhrig, Somi Reddy Majjigapu, Marc Chambon, Sylvian Bron, Luc Pilotte, Didier Colau, Benoit J. Van den Eynde, Gerardo Turcatti, Pierre Vogel, Vincent Zoete et al. · 2014 · European Journal of Medicinal Chemistry
- CD40 ligation reverses T cell tolerance in acute myeloid leukemiaLong Zhang, Xiufen Chen, Xiao Liu, Douglas E. Kline, Ryan M. Teague, Thomas F. Gajewski, Justin Paul Kline · 2013 · Journal of Clinical Investigation
- Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomyTomoko Inaba, Kazuhiko Ino, Hiroaki Kajiyama, Kiyosumi Shibata, Eiko Yamamoto, Shinji Kondo, Tomokazu Umezu, Akihiro Nawa, Osamu Takikawa, Fumitaka Kikkawa · 2010 · Gynecologic Oncology
- IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinomaAlex B. Blair, Jennifer Kleponis, Dwayne L. Thomas, Stephen T. Muth, Adrian Gerard Murphy, Victoria Kim, Lei Zheng · 2019 · Journal of Clinical Investigation
- The effects of age and systemic metabolism on anti-tumor T cell responsesDrijvers, Jefte M, Sharpe, Arlene H, Haigis, Marcia C · 2020 · eLife
- The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesionsMario Preti, Elmar Armin Joura, Pedro Vieira‐Baptista, Marc van Beurden, Federica Bevilacqua, Maaike C.G. Bleeker, Jacob Bornstein, Xavier Carcopino, Cyrus Chargari, Margaret Eleanor Cruickshank et al. · 2022 · International Journal of Gynecological Cancer
- Cancer immunotherapy takes a multi-faceted approach to kick the immune system into gear.Peniel Dimberu, Ralf M. Leonhardt · 2011 · Europe PMC (PubMed Central)
- Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymisAurore Britan, Violette Maffre, Shigenobu Toné, Joël R. Drevet · 2006 · Cell and Tissue Research
- Indoleamine 2,3‐dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment優子 谷崎, Aya Kobayashi, Saori Toujima, Michihisa Shiro, Mika Mizoguchi, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Osamu Takikawa, Kazuhiko Ino · 2014 · Cancer Science
- Interleukins 1α and 1β secreted by some melanoma cell lines strongly reduce expression of MITF‐M and melanocyte differentiation antigensOlga Kholmanskikh, Nicolas van Baren, Francis Brasseur, Sabrina Ottaviani, Julie Vanacker, Nathalie Arts, Pierre van der Bruggen, Pierre G. Coulie, Etienne De Plaen · 2010 · International Journal of Cancer
- Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium -Induced ColitisLynne Harrington, Chittur V. Srikanth, Reuben Antony, Sue Rhee, Andrew L. Mellor, Hai Ning Shi, Bobby J. Cherayil · 2008 · Infection and Immunity
- Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New DrugsGianfranco Pittari, Luca Vago, Moreno Benedetto Festuccia, Chiara Bonini, Deena Mudawi, Luisa Giaccone, Benedetto Bruno · 2017 · Frontiers in Immunology
- Interferons: Reprogramming the Metabolic Network against Viral InfectionKavita Raniga, Chen Liang · 2018 · Viruses
- The paradox of T cell?mediated antitumor immunity in spite of poor clinical outcome in human melanomaAndrea Anichini, Claudia Vegetti, Roberta Mortarini · 2004 · Cancer Immunology Immunotherapy
- Immune Checkpoint Blockade in Cancer Treatment: A Double-Edged Sword Cross-Targeting the Host as an “Innocent Bystander”Lucia Gelao, Carmen Criscitiello, Angela Espósito, Aron Goldhirsch, Giuseppe Curigliano · 2014 · Toxins
- Immune Mechanisms in Myelodysplastic SyndromeAndreas Birkedal Glenthøj, Andreas Due Ørskov, Jakob Hansen, Sine Reker Hadrup, Casey Lee O'Connell, Kirsten Grønbæk · 2016 · International Journal of Molecular Sciences
- Effects of microenvironment in osteosarcoma on chemoresistance and the promise of immunotherapy as an osteosarcoma therapeutic modalityLei Yu, Jian Zhang, Yunfeng Li · 2022 · Frontiers in Immunology
- Nitration and Inactivation of IDO by PeroxynitriteHidetsugu Fujigaki, Kuniaki Saito, Felix Lin, Suwako Fujigaki, Kanako Takahashi, Brian M. Martin, Cai Y. Chen, Junichi Masuda, Jeffrey A. Kowalak, Osamu Takikawa et al. · 2006 · The Journal of Immunology
- Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcomaHiroshi Urakawa, Yoshihiro Nishida, Hiroatsu Nakashima, Yoshie Shimoyama, Shigeo Nakamura, Naoki Ishiguro · 2009 · Clinical & Experimental Metastasis
- Peritumoral indoleamine 2,3‐dioxygenase expression in melanoma: an early marker of resistance to immune control?Inès Chevolet, Reinhart Speeckaert, Marc Haspeslagh, Bart Neyns, Vibeke Krüse, Max S. Schreuer, Mireille Van Gele, Nanja van Geel, Liève Brochez · 2014 · British Journal of Dermatology
- The Immune System Strikes Back: Cellular Immune Responses against Indoleamine 2,3-dioxygenaseRikke Bæk Sørensen, Linda Berge-Hansen, Niels Junker, Christina Aaen Hansen, Sine Reker Hadrup, Ton N. Schumacher, Inge Marie Svane, Jürgen Christian Becker, Per thor Straten, Mads Hald Andersen · 2009 · PLoS ONE
- Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic markerYutaka IHATA, Etsuko Miyagi, Reiko Numazaki, Takahiko Muramatsu, Akira Imaizumi, Hiroshi Yamamoto, Minoru Yamakado, Naoyuki Okamoto, Fumiki Hirahara · 2013 · International Journal of Clinical Oncology
- BAR the door: Cancer suppression by amphiphysin-like genesPrendergast, George C., Muller, Alexander J., Ramalingam, Arivudanambi, Chang, Mee Young · 2009 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Reverting Immune Suppression to Enhance Cancer ImmunotherapyBella Samia Guerrouahen, Cristina Maccalli, Chiara Cugno, Sergio Rutella, Emmanuel T. Akporiaye · 2020 · Frontiers in Oncology
- Indoleamine 2,3-dioxygenase activity and l-tryptophan transport in human breast cancer cellsM T Travers, Iain F Gow, MICHAEL C. BARBER, Jean Thomson, DAVID B. SHENNAN · 2003 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myelomaGiuseppina Bonanno, Andrea Mariotti, Annabella Procoli, Valentina Folgiero, Daniela Natale, Luca De Rosa, Ignazio Majolino, Linda Novarese, Alberto Rocci, Manuela Gambella et al. · 2012 · Journal of Translational Medicine
- Immune checkpoint blockade and its combination therapy with small-molecule inhibitors for cancer treatmentWang, Manni, Liu, Yu, Cheng, Yuan, Wei, Yuquan, Wei, Xiawei · 2019 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Noncoding RNAs: the shot callers in tumor immune escapeLei Liu, Qin Wang, Zhilin Qiu, Yujuan Kang, Jiena Liu, Shipeng Ning, Yanling Yin, Da Pang, Shouping Xu · 2020 · Signal Transduction and Targeted Therapy
- The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor MicroenvironmentXinting Huang, Feng Zhang, Xiaobo Wang, Ke Liu · 2022 · Cancers
- Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapyTakeshi Miyazaki, Kouzo Moritake, Kazuo Yamada, Nobumasa Hara, Harumi Osago, Tomoko Shibata, Yasuhiko Akiyama, Mikako Tsuchiya · 2009 · Journal of neurosurgery
- The missing link between indoleamine 2,3‐dioxygenase mediated antibacterial and immunoregulatory effectsAnika Müller, Kathrin Heseler, Silvia K. Schmidt, Katrin Spekker, Colin R. MacKenzie, Walter Däubener · 2008 · Journal of Cellular and Molecular Medicine
- The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancerYan-fang Gao, Ruiqing Peng, Jiang Li, Ya Ding, Xing Zhang, Xiaojun Wu, Zhizhong Pan, De-Sen Wan, Yi-Xin Zeng, Xiaoshi Zhang · 2009 · Journal of Translational Medicine
- A high-affinity, tryptophan-selective amino acid transport system in human macrophagesRobert L. Seymour, Vadivel Ganapathy, Andrew L. Mellor, David H. Munn · 2006 · Journal of Leukocyte Biology
- Safety and Antitumor Activity of α-PD-L1 Antibody as Monotherapy or in Combination with α-TIM-3 Antibody in Patients with Microsatellite Instability–High/Mismatch Repair–Deficient TumorsHollebecque, Antoine, Chung, Hyun C., de Miguel, Maria J., Italiano, Antoine, Machiels, Jean-Pascal, Lin, Chia-Chi, Dhani, Neesha C., Peeters, Marc, Moreno, Victor, Su, Wu-Chou et al. · 2021 · Clinical Cancer Research
- Tumour‐induced immune suppression: role of inflammatory mediators released by myelomonocytic cellsYumeng Mao, Isabel C. Poschke, Rolf W. Kiessling · 2014 · Journal of Internal Medicine
- A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor–Infiltrating LymphocytesNathalie Demotte, René Bigirimana, Grégoire Wieërs, Vincent Stroobant, Jean-Luc Squifflet, Javier Carrasco, Kris Thielemans, Jean‐François Baurain, Patrick Van Deŕ Smissen, Pierre J. Courtoy et al. · 2014 · Clinical Cancer Research
- A short history of heme dioxygenases: rise, fall and rise againEmma Lloyd Raven · 2016 · JBIC Journal of Biological Inorganic Chemistry
- Immunotherapy in colorectal cancer: for the select few or all?Sukeshi Patel Arora, Devalingam Mahalingam · 2018 · Journal of Gastrointestinal Oncology
- Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder CancerWentao Zhang, Junfeng Zhang, Ziwei Zhang, Yadong Guo, Yuan Wu, Ruiliang Wang, Longsheng Wang, Shiyu Mao, Xudong Yao · 2018 · Translational Oncology
- Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growthThuy Xuan Phan, Vu H. Nguyen, Marcela d'Alincourt Salazar, Edwin Ramos Manuel, Teodora I. Kaltcheva, Weimin Tsai, Bruce R. Blazar, Don J. Diamond, Laleh Golkar Melstrom · 2019 · Cancer Gene Therapy
- Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac diseaseMarı́a Isabel Torres, M A López-Casado, Pedro Lorite, Antonio Ríos · 2007 · Clinical & Experimental Immunology
- The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomasSonner, Jana K., Deumelandt, Katrin, Ott, Martina, Thomé, Carina M., Rauschenbach, Katharina J., Schulz, Sandra, Munteanu, Bogdan, Mohapatra, Soumya, Adam, Isabell, Hofer, Ann-Cathrin et al. · 2016 · OncoImmunology
- Targeting the Immunoregulatory Indoleamine 2,3 Dioxygenase Pathway in ImmunotherapyBurles A Johnson rd, Babak Baban, Andrew L. Mellor · 2009 · Immunotherapy
- The emerging role of viruses in the treatment of solid tumoursM.G. Bourke, S. Salwa, Kevin Joseph Harrington, Michael Jonathan Kucharczyk, Patrick F. Forde, M. de Kruijf, Declan M. Soden, Mark Tangney, John Kevin Collins, Gerald C. O’Sullivan · 2011 · Cancer Treatment Reviews
- Recent advances and future of immunotherapy for glioblastomaNeha Kamran, Anda‐Alexandra Calinescu, Marianela Candolfi, Mayuri Chandran, Yohei Mineharu, Antonela Sofía Asad, Carl Johannes Koschmann, Felipe Javier Núñez, Pedro Ricardo Lowenstein, Maria Graciela Castro · 2016 · Expert Opinion on Biological Therapy
- Sculpting tumor microenvironment with immune system: from immunometabolism to immunoeditingY-R Yu, Ping‐Chih Ho · 2019 · Clinical & Experimental Immunology
- NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in CancerValentina Audrito, Antonella Managò, Federica Gaudino, Leonardo Sorci, Vincenzo Gianluca Messana, Nadia Raffaelli, Silvia Deaglio · 2019 · Frontiers in Immunology
- Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical applicationYan Pan, Hanqiong Zhou, Zhenqiang Sun, Yichen Zhu, Zhe Zhang, Jing Han, Yang Liu, Qiming Wang · 2025 · Cell Death and Disease
- Cytokine gene therapy for malignant gliomaHideho Okada, Ian F. Pollack · 2004 · Expert Opinion on Biological Therapy
- Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancerJosephine F. Trott, Jeffrey J. Kim, Omran Abu Aboud, Hiromi Inoue Wettersten, Benjamin J. Stewart, Grace E. Berryhill, Francisco Alejandro Uzal, Russell C. Hovey, Ching‐Hsien Chen, Katie Anderson et al. · 2016 · Oncotarget
- Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual InhibitorsKun Fang, Guoqiang Dong, Yu Li, Shipeng He, Ying Wu, Shanchao Wu, Wei Wang, Chunquan Sheng · 2018 · ACS Medicinal Chemistry Letters
- Novel Approaches to Acute Myeloid Leukemia ImmunotherapyOfrat Beyar‐Katz, Saar I. Gill · 2018 · Clinical Cancer Research
- Role of IFNγ in Allograft Tolerance Mediated by CD4+CD25+ Regulatory T Cells by Induction of IDO in Endothelial CellsPaméla Thébault, Thomas Condamine, M Heslan, Marcelo Hill, I Bernard, Abdelhadi Saoudi, Régis Josien, Ignacio Anegón, María Cristina Cuturi, Elise Chiffoleau · 2007 · American Journal of Transplantation
- Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferationFeng Qian, Jianqun Liao, Jeannine Villella, Robert P. Edwards, Paweł Kaliński, Shashikant Lele, Protul A. Shrikant, Kunle O. Odunsi · 2012 · Cancer Immunology Immunotherapy
- Production of an antigenic peptide by insulin-degrading enzymeNicolas Parmentier, Vincent Stroobant, Didier Colau, Philippe de Diesbach, Sandra Morel, Jacques Chapiro, Peter Van Endert, Benoit J. Van den Eynde · 2010 · Nature Immunology
- Regional immunity in melanoma: immunosuppressive changes precede nodal metastasisAaron Scott Mansfield, Shernan G. Holtan, Travis Edward Grotz, Jake Allred, James W. Jakub, Lori A. Erickson, Svetomir N. Markovic · 2010 · Modern Pathology
- Major Developments in the Design of Inhibitors along the Kynurenine PathwayKelly R. Jacobs, Gloria Castellano‐González, Gilles J. Guillemin, David B. Lovejoy · 2017 · Current Medicinal Chemistry