Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Uyttenhove, Catherine, Pilotte, Luc, Théate, Ivan, Stroobant, Vincent, Colau, Didier, Parmentier, Nicolas, Boon, Thierry, Van den Eynde, Benoît J·2003·Nature Medicine

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Items 101–200 of 1,003

  1. Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells
    Cham, Candace M, Gajewski, Thomas F · 2005 · The Journal of Immunology
  2. Immunosuppressive mechanisms in glioblastoma: Fig. 1.
    Edjah Kweku-Ebura Nduom, Michael Weller, Amy B. Heimberger · 2015 · Neuro-Oncology
  3. The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity
    Mbongue, Jacques, Nicholas, Dequina, Torrez, Timothy, Kim, Nan-Sun, Firek, Anthony, Langridge, William · 2015 · Vaccines
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    Hartung, T.J., Brähler, E., Faller, H., Härter, M., Hinz, A., Johansen, C., Keller, M., Koch, U., Schulz, H., Weis, J. et al. · 2017 · European Journal of Cancer
  5. Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression
    Wei Ge, Jifu Jiang, Jacqueline Arp, Weihua Liu, Bertha M Garcia, Hao Wang · 2010 · Transplantation
  6. Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated l-tryptophan metabolism
    Osamu Takikawa · 2005 · Biochemical and Biophysical Research Communications
  7. Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors
    Yanqi Ye, Jinqiang Wang, Quanyin Hu, Gabrielle M. Hochu, Hongliang Xin, Chao Wang, Zhen Gu · 2016 · ACS Nano
  8. Twelve immunotherapy drugs that could cure cancers
    Martin A. Cheever · 2008 · Immunological Reviews
  9. T Cell Dysfunction in Cancer Immunity and Immunotherapy
    Anliang Xia, Yan Zhang, Xu Jiang, Tailang Yin, Xiaojie Lu · 2019 · Frontiers in Immunology
  10. Targeting the indoleamine 2,3-dioxygenase pathway in cancer
    Yong Wha Moon, Joud Hajjar, Patrick Hwu, Aung Naing · 2015 · Journal for ImmunoTherapy of Cancer
  11. Cytokines as a key component of cancer-related inflammation
    Giovanni Germano, Paola Allavena, Alberto Mantovani · 2008 · Cytokine
  12. Oncolytic viruses in cancer therapy
    Markus J. V. Vähä-Koskela, Jari Heikkilä, Ari Hinkkanen · 2007 · Cancer Letters
  13. Trial watch: IDO inhibitors in cancer therapy
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  14. Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy
    Lijie Zhai, Stefani Spranger, David C. Binder, Galina Gritsina, Kristen L. Lauing, Francis Joseph Giles, Derek Alan Wainwright · 2015 · Clinical Cancer Research
  15. Characterization of the Kynurenine Pathway in Human Neurons
    Gilles J. Guillemin, Karen M. Cullen, Chai K. Lim, George A. Smythe, Brett Garner, Vimal Kapoor, Osamu Takikawa, Bruce James Brew · 2007 · Journal of Neuroscience
  16. Immune escape as a fundamental trait of cancer: focus on IDO
    George C. Prendergast · 2008 · Oncogene
  17. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy
    Keman Cheng, Yanping Ding, Ying Zhao, Shefang Ye, Xiao Zhao, Yinlong Zhang, Tianjiao Ji, Huanhuan Wu, Bin Wang, Gregory Jon Anderson et al. · 2018 · Nano Letters
  18. Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
    Ulrike M. Litzenburger, Christiane A. Opitz, Felix Sahm, Katharina J. Rauschenbach, Saskia Trump, Marcus Winter, Martina Ott, Katharina Ochs, Christian Lutz, Xiangdong Liu et al. · 2014 · Oncotarget
  19. IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
    Courtney Smith, Mee Young Chang, Katherine H. Parker, Daniel W. Beury, James B. DuHadaway, Hollie E. Flick, Janette Boulden, Erika Sutanto‐Ward, Alejandro Peralta Soler, Lisa D. Laury‐Kleintop et al. · 2012 · Cancer Discovery
  20. Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer
    Lena Cords, Stefanie Engler, Martina Haberecker, Jan H. Rüschoff, Holger Moch, Natalie de Souza, Bernd Bodenmiller · 2024 · Cancer Cell
  21. Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs
    Soranobu Ninomiya, Neeharika Narala, Leslie E. Huye, Shigeki Yagyu, Barbara Savoldo, Gianpietro Dotti, Helen Elisabeth Heslop, Malcolm K. Brenner, Cliona M. Rooney, Carlos A. Ramos · 2015 · Blood
  22. Emerging targets in cancer immunotherapy
    Samantha Burugu, Amanda R. Dancsok, Torsten O. Nielsen · 2017 · Seminars in Cancer Biology
  23. First-in-human phase I study of the oral inhibitor of indoleamine 2,3-dioxygenase-1 epacadostat (INCB024360) in patients with advanced solid malignancies
    Beatty, Gregory L., O'Dwyer, Peter J., Clark, Jason, Shi, Jack G., Bowman, Kevin J., Scherle, Peggy A., Newton, Robert C., Schaub, Richard, Maleski, Janet, Leopold, Lance et al. · 2017 · Clinical Cancer Research
  24. Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14−/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer
    Chien‐Ying Liu, Yumin Wang, Chih-Liang Wang, Po‐Hao Feng, How‐Wen Ko, Yun‐Hen Liu, Yi‐Cheng Wu, Yen Chu, Fu‐Tsai Chung, Chih-Hsi Scott Kuo et al. · 2009 · Journal of Cancer Research and Clinical Oncology
  25. Inflammatory cell infiltration of tumors: Jekyll or Hyde
    James E. Talmadge, Moses K. Donkor, Eric M. Scholar · 2007 · Cancer and Metastasis Reviews
  26. Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
    Riera-Domingo, Carla, Audigé, Annette, Granja, Sara, Cheng, Wan-Chen, Ho, Ping-Chih, Baltazar, Fátima, Stockmann, Christian, Mazzone, Massimiliano · 2020 · Physiological Reviews
  27. Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy
    Yu Fujiwara, Shumei Kato, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Sarabjot Pabla, Razelle Kurzrock · 2022 · Cancer Treatment Reviews
  28. ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
    Garg, Abhishek D., Dudek, Aleksandra M., Ferreira, Gabriela B., Verfaillie, Tom, Vandenabeele, Peter, Krysko, Dmitri V., Mathieu, Chantal, Agostinis, Patrizia · 2013 · Autophagy
  29. IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism
    Stefan Löb, Alfred Königsrainer, Derek Zieker, Björn L.D.M. Brücher, Hans‐Georg Rammensee, Gerhard Opelz, Peter Terness · 2008 · Cancer Immunology Immunotherapy
  30. INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
    Eddy W. Yue, Richard B. Sparks, Padmaja K Polam, Dilip Modi, Brent D. Douty, Brian R. Wayland, Brian M. Glass, Amy G. Takvorian, Joseph Glenn, Wenyu Zhu et al. · 2017 · ACS Medicinal Chemistry Letters
  31. Stromal Cells in the Tumor Microenvironment
    Alice E. Denton, Edward W. Roberts, Douglas T. Fearon · 2018 · Advances in experimental medicine and biology
  32. Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy
    Hathaichanok Phuengkham, Long Fang Ren, Il Woo Shin, Yong Taik Lim · 2019 · Advanced Materials
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    Nicholas A. Ullman, Paul R. Burchard, Richard Francis Dunne, David C. Linehan · 2022 · Journal of Clinical Oncology
  34. CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
    Ciriana Orabona, Ursula Grohmann, Maria Laura Belladonna, Francesca Fallarino, Carmine Vacca, Roberta Bianchi, Silvia Bozza, Claudia Volpi, Benoı̂t L. Salomon, Maria Cristina Fioretti et al. · 2004 · Nature Immunology
  35. The therapeutic potential of targeting tryptophan catabolism in cancer
    Opitz, Christiane A., Somarribas Patterson, Luis F., Mohapatra, Soumya R., Dewi, Dyah L., Sadik, Ahmed, Platten, Michael, Trump, Saskia · 2020 · British Journal of Cancer
  36. Effector and regulatory events during natural killer–dendritic cell interactions
    Lorenzo Moretta, Guido Ferlazzo, Cristina Bottino, Massimo Vitale, Daniela Pende, Maria Cristina Mingari, Alessandro Moretta · 2006 · Immunological Reviews
  37. Lipoxygenase metabolism: roles in tumor progression and survival
    Graham P. Pidgeon, Joanne Lysaght, Sriram Krishnamoorthy, John Vincent Reynolds, Kenneth John O'Byrne, Daotai Nie, Kenneth V. Honn · 2007 · Cancer and Metastasis Reviews
  38. The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance
    Fearon, Douglas T. · 2014 · Cancer Immunology Research
  39. Tryptophan Metabolism as a Pharmacological Target
    Morgane Modoux, Nathalie Rolhion, Sridhar Mani, Harry Sokol · 2020 · Trends in Pharmacological Sciences
  40. Nanomaterials for cancer immunotherapy
    Wantong Song, Sara Musetti, Leaf Huang · 2017 · Biomaterials
  41. Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors
    Kyung Hae Jung, Patricia Mucci LoRusso, Howard A. Burris, Michael S. Gordon, Yung‐Jue Bang, Matthew David Hellmann, Andrès M.R. Cervantes, María Ochoa de Olza, Aurélien Marabelle, Frank Stephen Hodi et al. · 2019 · Clinical Cancer Research
  42. Immune control by amino acid catabolism during tumorigenesis and therapy
    Henrique de Paula Lemos, Lei Huang, George C. Prendergast, Andrew L. Mellor · 2019 · Nature reviews. Cancer
  43. Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
    Annie A. Wu, Virginia E. Drake, Huai-Shiuan Huang, ShihChi Chiu, Lei Zheng · 2015 · OncoImmunology
  44. Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer
    George C. Prendergast, William P. Malachowski, Arpita Mondal, Peggy Scherle, Alexander J. Muller · 2017 · International review of cytology
  45. The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy
    Liève Brochez, Inès Chevolet, Vibeke Krüse · 2017 · European Journal of Cancer
  46. Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization
    Su-Mei Chen, Haitao Zhu, Y. Jounaidi · 2024 · Signal Transduction and Targeted Therapy
  47. Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond
    Alexander J. Muller, Mark G Manfredi, Yousef Zakharia, George C. Prendergast · 2018 · Seminars in Immunopathology
  48. Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
    Alexander J. Muller, Peggy Scherle · 2006 · Nature reviews. Cancer
  49. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
    Yuzo Suzuki, Takafumi Suda, Kazuki Furuhashi, Masako Suzuki, Michio Fujie, Dai Hahimoto, Yutaro Nakamura, Naoki Inui, Hirotoshi Nakamura, Kingo Chida · 2009 · Lung Cancer
  50. Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function
    Suzanne M. Adam, Gayan B. Wijeratne, Patrick J. Rogler, Daniel E. Díaz, David A. Quist, Jeffrey J. Liu, Kenneth D. Karlin · 2018 · Chemical Reviews
  51. Tryptophan and indole metabolism in immune regulation
    Alessandra Fiore, Peter J. Murray · 2021 · Current Opinion in Immunology
  52. Immune Suppression in the Tumor Microenvironment
    Thomas Frank Gajewski, Yuru Meng, Helena Harlin · 2006 · Journal of Immunotherapy
  53. BiTEs: bispecific antibody constructs with unique anti-tumor activity
    Wolf, Evelyn, Hofmeister, Robert, Kufer, Peter, Schlereth, Bernd, Baeuerle, Patrick A. · 2005 · Drug Discovery Today
  54. The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
    Antonio Curti, Sara Trabanelli, Valentina Salvestrini, Michele Baccarani, Roberto Massimo Lemoli · 2008 · Blood
  55. A Convergence-Based Framework for Cancer Drug Resistance
    Konieczkowski, David J., Johannessen, Cory M., Garraway, Levi A. · 2018 · Cancer Cell
  56. IDO and tolerance to tumors
    David H. Munn, Andrew L. Mellor · 2003 · Trends in Molecular Medicine
  57. STAT1 and STAT3 in tumorigenesis
    Lidia Avalle, Sara Pensa, Gabriella Regis, Francesco Novelli, Valeria Poli · 2012 · JAK-STAT
  58. Targeting T cell metabolism for therapy
    David O’Sullivan, Erika L. Pearce · 2015 · Trends in Immunology
  59. The tumor‐draining lymph node as an immune‐privileged site
    David H. Munn, Andrew L. Mellor · 2006 · Immunological Reviews
  60. Gene Signature in Melanoma Associated With Clinical Activity: A Potential Clue to Unlock Cancer Immunotherapy
    Gajewski, Thomas F., Louahed, Jamila, Brichard, Vincent G. · 2010 · The Cancer Journal
  61. Prognostic implications of immunosuppressive protein expression in tumors as well as immune cell infiltration within the tumor microenvironment in gastric cancer
    Jin Won Kim, Kyung Han Nam, Sang-Hoon Ahn, Do Joong Park, Hyung‐Ho Kim, Se Hyun Kim, Hyun Kyung Chang, Jeong‐Ok Lee, Yu Jung Kim, Hye Seung Lee et al. · 2014 · Gastric Cancer
  62. Clinical cancer immunotherapy: Current progress and prospects
    Chenglong Liu, Mengxuan Yang, Daizhou Zhang, Ming Chen, Di Zhu · 2022 · Frontiers in Immunology
  63. Natural and Induced T Regulatory Cells in Cancer
    Dennis O. Adeegbe, Hiroyoshi Nishikawa · 2013 · Frontiers in Immunology
  64. Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer
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  65. Whole tumor antigen vaccines
    Cheryl Lai-Lai Chiang, Fabián Benencia, George Coukos · 2010 · Seminars in Immunology
  66. The immune system and inflammation in breast cancer
    Xinguo Jiang, David J. Shapiro · 2013 · Molecular and Cellular Endocrinology
  67. Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors
    Holly K. Koblish, Michael Hansbury, Kevin Bowman, Gengjie Yang, Claire L. Neilan, Patrick J. Haley, Timothy C. Burn, Paul Waeltz, Richard B. Sparks, Eddy W. Yue et al. · 2010 · Molecular Cancer Therapeutics
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  78. Failure at the Effector Phase: Immune Barriers at the Level of the Melanoma Tumor Microenvironment
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  80. Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment
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  84. The Physiological Action of Picolinic Acid in the Human Brain
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  86. Metabolomic adaptations and correlates of survival to immune checkpoint blockade
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  88. Cancer‐related circulating and tumor‐associated neutrophils – subtypes, sources and function
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  89. Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
    Micah T. Nelp, Patrick A. Kates, John T. Hunt, John A. Newitt, Aaron Balog, Derrick Maley, Xiao Bing Zhu, Lynn M. Abell, Alban J. Allentoff, R. M. Borzilleri et al. · 2018 · Proceedings of the National Academy of Sciences
  90. A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments
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  91. Metabolic Control of Dendritic Cell Functions: Digesting Information
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  94. The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells
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  95. Current Perspectives in Cancer Immunotherapy
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  96. IDO Expression in Cancer: Different Compartment, Different Functionality?
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  97. Immune system: a double-edged sword in cancer
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  99. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma.
    Darryl A. Oble, Robert P. Loewe, Ping Yu, Martín C. Mihm · 2009 · PubMed Central
  100. Biologically active quinoline and quinazoline alkaloids part II
    Xiaofei Shang, Susan Lynne Morris-Natschke, Guan‐Zhou Yang, Ying‐Qian Liu, Xiao Guo, Xiaoshan Xu, Masuo Goto, Juncai Li, Jiyu Zhang, Kuo‐Hsiung Lee · 2018 · Medicinal Research Reviews