The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Self-assembled RNA interference microsponges for efficient siRNA delivery
Open accessAbstract
The encapsulation and delivery of short interfering RNA (siRNA) has been realized using lipid nanoparticles1,2, cationic complexes3,4, inorganic nanoparticles5–8, RNA nanoparticles9,10 and dendrimers11. Still, the instability of RNA and the relatively ineffectual encapsulation process of siRNA remain critical issues towards the clinical translation of RNA as a therapeutic1,12,13. Here we report the synthesis of a delivery vehicle that combines carrier and cargo: RNA interference (RNAi) polymers that self-assemble into nanoscale pleated sheets of hairpin RNA, which in turn form sponge-like microspheres. The RNAi-microsponges consist entirely of cleavable RNA strands, and are processed by the cell’s RNA machinery to convert the stable hairpin RNA to siRNA only after cellular uptake, thus inherently providing protection for siRNA during delivery and transport to the cytoplasm. More than half a million copies of siRNA can be delivered to a cell with the uptake of a single RNAi-microsponge. The approach could lead to novel therapeutic routes for siRNA delivery.
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Cites
Rational design of cationic lipids for siRNA delivery
Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822 · cited 1×
“Because both ends of the linear DNA are also partially complementary to the T7 promoter sequence, the long strand is hybridized with a short DNA strand containing the T7 promoter sequence to form circular DNA [1] (see Supplementary Table S1).”
Heterochromatin and Epigenetic Control of Gene Expression
Grewal, S. I. S., & Moazed, D. (2003) · Science · doi:10.1126/science.1086887 · Cited by 1,065
Cited by
Self‐assembled DNA nanoclews for the efficient delivery of CRISPR–Cas9 for genome editing
Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506030 · Cited by 629
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications
Zhu, G., Hu, R., Zhao, Z., Chen, Z., Zhang, X., & Tan, W. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406115e · Cited by 429
MicroRNA therapeutics: Discovering novel targets and developing specific therapy
Bansal, P., Christopher, A., Kaur, R., Kaur, G., Kaur, A., & Gupta, V. (2016) · Perspectives in Clinical Research · doi:10.4103/2229-3485.179431 · Cited by 360
Advancement of the emerging field of RNA nanotechnology
Jasinski, D., Haque, F., Binzel, D. W., & Guo, P. (2017) · ACS Nano · doi:10.1021/acsnano.6b05737 · Cited by 352
Metadata
- Authors
- Lee, J. B., Hong, J., Bonner, D. K., Poon, Z., & Hammond, P. T.
- Venue
- Nature Materials
- Published
- 2012-02-26
- Volume
- 11
- Issue
- 4
- Pages
- 316-322
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W1525478498
- Cited by
- 494
- References
- 2
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, J. B., Hong, J., Bonner, D. K., Poon, Z., & Hammond, P. T. (2012). Self-assembled RNA interference microsponges for efficient siRNA delivery. Nature Materials. https://doi.org/10.1038/nmat3253
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