Advancement of the emerging field of RNA nanotechnology
Open accessAbstract
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been developed for diverse applications in nanobiotechnology. The rising popularity of RNA nanoparticles is due to a number of factors: (1) removing the concern of RNA degradation in vitro and in vivo by introducing chemical modification into nucleotides without significant alteration of the RNA property in folding and self-assembly; (2) confirming the concept that RNA displays very high thermodynamic stability and is suitable for in vivo trafficking and other applications; (3) obtaining the knowledge to tune the immunogenic properties of synthetic RNA constructs for in vivo applications; (4) increased understanding of the 4D structure and intermolecular interaction of RNA molecules; (5) developing methods to control shape, size, and stoichiometry of RNA nanoparticles; (6) increasing knowledge of regulation and processing functions of RNA in cells; (7) decreasing cost of RNA production by biological and chemical synthesis; and (8) proving the concept that RNA is a safe and specific therapeutic modality for cancer and other diseases with little or no accumulation in vital organs. Other applications of RNA nanotechnology, such as adapting them to construct 2D, 3D, and 4D structures for use in tissue engineering, biosensing, resistive biomemory, and potential computer logic gate modules, have stimulated the interest of the scientific community. This review aims to outline the current state of the art of RNA nanoparticles as programmable smart complexes and offers perspectives on the promising avenues of research in this fast-growing field.
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DNA and RNA nanotechnologies have been applied to deliver RNA therapeutics such as siRNA and miRNA, mainly for cancer therapy.
“In addition to viral vectors, DNA and RNA nanotechnologies have also been applied to deliver RNA therapeutics such as siRNA and miRNA, which are mainly used for cancer therapy.[24, 29–33]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [24]
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- Grodzinski P., Torchilin V., Eds. Advanced Drug Delivery Reviews: Cancer Nanotechnology; Elsevier: Amsterdam, 2014; Vol. 66.
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RNA delivery biomaterials for the treatment of genetic and rare diseases
Zhao, W., Hou, X., Vick, O. G., & Dong, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119291 · Cited by 82 · see citing works
- Authors
- Jasinski, D., Haque, F., Binzel, D. W., & Guo, P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Guo, Peixuan
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-01-03
- Volume
- 11
- Issue
- 2
- Pages
- 1142-1164
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- PMC
- PMC5333189
- OpenAlex
- W2563634884
- Cited by
- 352
- References
- 236
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 28 · 2023: 40 · 2022: 43 · 2021: 54 · 2020: 49 · 2019: 36 · 2018: 35 · 2017: 17
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- ACS Nano (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (U01CA151648, U01CA207946)
- National Institute of Biomedical Imaging and Bioengineering (R01EB019036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- RNA nanotechnology, RNA nanoparticles, RNA self-assembly, RNA therapeutics, tissue engineering, biosensing, logic gates, nanobiotechnology
- MeSH terms
- Animals, Neoplasms, RNA, Thermodynamics, Nanotechnology, Nanoparticles
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