The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Polymer multilayer tattooing for enhanced DNA vaccination
Open accessAbstract
DNA vaccines have many potential benefits but have failed to generate robust immune responses in humans. Recently, methods such as in vivo electroporation have demonstrated improved performance, but an optimal strategy for safe, reproducible, and pain-free DNA vaccination remains elusive. Here we report an approach for rapid implantation of vaccine-loaded polymer films carrying DNA, immune-stimulatory RNA, and biodegradable polycations into the immune-cell-rich epidermis, using microneedles coated with releasable polyelectrolyte multilayers. Films transferred into the skin following brief microneedle application promoted local transfection and controlled the persistence of DNA and adjuvants in the skin from days to weeks, with kinetics determined by the film composition. These “multilayer tattoo” DNA vaccines induced immune responses against a model HIV antigen comparable to electroporation in mice, enhanced memory T-cell generation, and elicited 140-fold higher gene expression in non-human primate skin than intradermal DNA injection, indicating the potential of this strategy for enhancing DNA vaccination.
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Cites
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
DNA vaccines: ready for prime time?
Kutzler, M. A., & Weiner, D. B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2432 · Cited by 1,077
Cited by
Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
A holistic approach to targeting disease with polymeric nanoparticles
Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., & Saltzman, W. M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4503 · Cited by 480
Polymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Santa Chalarca, C. F., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 365
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald
Zhao, S., Caruso, F., Dähne, L., Decher, G., De Geest, B. G., Fan, J., Feliu, N., Gogotsi, Y., Hammond, P. T., Hersam, M. C., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03326 · Cited by 283
Self-citationNanotechnology: emerging tools for biology and medicine
Wong, I. Y., Bhatia, S. N., & Toner, M. (2013) · Genes & Development · doi:10.1101/gad.226837.113 · Cited by 132
Metadata
- Authors
- DeMuth, P. C., Min, Y., Huang, B., Kramer, J. A., Miller, A. D., Barouch, D. H., Hammond, P. T., & Irvine, D. J.
- Venue
- Nature Materials
- Published
- 2013-01-27
- Volume
- 12
- Issue
- 4
- Pages
- 367-376
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2131018316
- Cited by
- 277
- References
- 2
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- DeMuth, P. C., Min, Y., Huang, B., Kramer, J. A., Miller, A. D., Barouch, D. H., Hammond, P. T., & Irvine, D. J. (2013). Polymer multilayer tattooing for enhanced DNA vaccination. Nature Materials. https://doi.org/10.1038/nmat3550
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