The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
Open accessAbstract
Transdermal drug delivery offers a number of advantages for the patient, due not only its non-invasive and convenient nature, but also factors such as avoidance of first pass metabolism and prevention of gastrointestinal degradation. It has been demonstrated that microneedle arrays can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum, and creating a pathway for drug permeation to the dermal tissue below. Microneedles have been extensively investigated in recent decades for drug and vaccine delivery as well as minimally invasive patient monitoring/diagnosis. This review focuses on a range of critically important aspects of microneedle technology, namely their material composition, manufacturing techniques, methods of evaluation and commercial translation to the clinic for patient benefit and economic return. Microneedle research and development is finally now at the stage where commercialisation is a realistic possibility. However, progress is still required in the areas of scaled-up manufacture and regulatory approval.
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Cites
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Cited by
Lab under the Skin: Microneedle Based Wearable Devices
Teymourian, H., Tehrani, F., Mahato, K., & Wang, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002255 · Cited by 310
3D‐Printed Hydrogel‐Filled Microneedle Arrays
Barnum, L., Quint, J., Derakhshandeh, H., Samandari, M., Aghabaglou, F., Farzin, A., Abbasi, L., Bencherif, S., Memic, A., Mostafalu, P., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001922 · Cited by 89
Kim, H. M., Byun, K.-A., Oh, S., Yang, J. Y., Park, H. J., Chung, M. S., Son, K. H., & Byun, K. (2022) · Molecules · doi:10.3390/molecules27041276 · Cited by 48
Miniaturized Needle Array‐Mediated Drug Delivery Accelerates Wound Healing
Samandari, M., Aghabaglou, F., Nuutila, K., Derakhshandeh, H., Zhang, Y., Endo, Y., Harris, S., Barnum, L., Kreikemeier‐Bower, C., Arab‐Tehrany, E., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001800 · Cited by 47
Metadata
- Authors
- Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F.
- Venue
- Materials Science and Engineering: R: Reports
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 104
- Pages
- 1-32
- ISSN
- 0927-796X (ISSN-L)
- OpenAlex
- W2335972983
- Cited by
- 964
- References
- 226
- FWCI
- 27.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016). Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports. https://doi.org/10.1016/j.mser.2016.03.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
