The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Engineering synthetic vaccines using cues from natural immunity
Open accessAbstract
Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. The former generate antibodies and T-cells poised to protect against future pathogen encounter or attack diseased cells such as tumors; the latter, which are far less developed, block pathogenic autoreactive T-cells and autoantibodies that target self tissue. Enormous challenges remain, however, as a consequence of our incomplete understanding of human immunity. A rapidly growing field of research is the design of synthetic materials in vaccines to 1) target organs, tissues, cells, or intracellular compartments; 2) co-deliver immunomodulatory signals that control the quality of the immune response; or 3) directly act as immune regulators, and there exists great potential for well-defined materials to further our understanding of immunity. Here we describe recent advances in the design of synthetic materials to direct immune responses, highlighting successes and challenges in prophylactic, therapeutic, and tolerance-inducing vaccines.
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Metadata
- Authors
- Irvine, D. J., Swartz, M. A., & Szeto, G. L.
- Venue
- Nature Materials
- Published
- 2013-10-23
- Volume
- 12
- Issue
- 11
- Pages
- 978-990
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W1524841546
- Cited by
- 594
- References
- 17
- FWCI
- 19.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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