The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Decision tree–driven tandem mass spectrometry for shotgun proteomics
Open accessAbstract
Mass spectrometry has become a key technology for modern large-scale protein sequencing. Tandem mass spectrometry, the process of peptide ion dissociation followed by mass-to-charge ratio (m/z) analysis, is the critical component for peptide identification. Recent advances in mass spectrometry now permit two discrete, and complementary, types of peptide ion fragmentation: collision-activated dissociation (CAD) and electron transfer dissociation (ETD) on a single instrument. To exploit this complementarity and increase sequencing success rates, we designed and embedded a data-dependent decision tree algorithm (DT) to make unsupervised, real-time decisions of which fragmentation method to use based on precursor charge and m/z. Applying the DT to large-scale proteome analyses of Saccharomyces cerevisiae and human embryonic stem cells, we identified 53,055 peptides in total, which was greater than by using CAD (38,293) or ETD (39,507) alone. In addition, the DT method also identified 7,422 phosphopeptides, compared to either 2,801 (CAD) or 5,874 (ETD) phosphopeptides.
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Cites
Mass spectrometry-based proteomics
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Self-citationLarge-scale phosphorylation analysis of mouse liver
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Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
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Phosphopeptide fragmentation and analysis by mass spectrometry
Boersema, P. J., Mohammed, S., & Heck, A. J. R. (2009) · Journal of Mass Spectrometry · doi:10.1002/jms.1599 · Cited by 362
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Moritz, A., Li, Y., Guo, A., Villén, J., Wang, Y., MacNeill, J., Kornhauser, J., Sprott, K., Zhou, J., Possemato, A., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2000998 · Cited by 300
Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa
Durbin, K. R., Fornelli, L., Fellers, R. T., Doubleday, P. F., Narita, M., & Kelleher, N. L. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00997 · Cited by 111
Advances in mass spectrometry driven O-glycoproteomics
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Quantitative measurement of allele‐specific protein expression in a diploid yeast hybrid by LC‐MS
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Metadata
- Authors
- Swaney, D. L., McAlister, G. C., & Coon, J. J.
- Venue
- Nature Methods
- Published
- 2008-10-19
- Volume
- 5
- Issue
- 11
- Pages
- 959-964
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2062406929
- Cited by
- 312
- References
- 4
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- green
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