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Intravital imaging of metastatic behavior through a mammary imaging window
Open accessAbstract
We report a technique to evaluate the same tumor microenvironment over multiple intravital imaging sessions in living mice. We optically marked individual tumor cells expressing photoswitchable proteins in an orthotopic mammary carcinoma and followed them for extended periods through a mammary imaging window. We found that two distinct microenvironments in the same orthotopic mammary tumor affected differently the invasion and intravasation of tumor cells.
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Citations
Cited by
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Kienast, Y., von Baumgarten, L., Fuhrmann, M., Klinkert, W. E. F., Goldbrunner, R., Herms, J., & Winkler, F. (2010) · Nature Medicine · doi:10.1038/nm.2072 · Cited by 1,138
Classifying collective cancer cell invasion
Friedl, P., Locker, J., Sahai, E., & Segall, J. E. (2012) · Nature Cell Biology · doi:10.1038/ncb2548 · Cited by 963
Self-citationThree-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872
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Metadata
- Authors
- Kedrin, D., Gligorijevic, B., Wyckoff, J., Verkhusha, V. V., Condeelis, J., Segall, J. E., & van Rheenen, J.
- Venue
- Nature Methods
- Published
- 2008-11-09
- Volume
- 5
- Issue
- 12
- Pages
- 1019-1021
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1999700615
- Cited by
- 391
- References
- 0
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Kedrin, D., Gligorijevic, B., Wyckoff, J., Verkhusha, V. V., Condeelis, J., Segall, J. E., & van Rheenen, J. (2008). Intravital imaging of metastatic behavior through a mammary imaging window. Nature Methods. https://doi.org/10.1038/nmeth.1269
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
