The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A 3D digital atlas of C. elegans and its application to single-cell analyses
Open accessAbstract
We built a digital nuclear atlas of the newly hatched, first larval stage (L1) of the wild-type hermaphrodite of Caenorhabditis elegans at single-cell resolution from confocal image stacks of 15 individual worms. The atlas quantifies the stereotypy of nuclear locations and provides other statistics on the spatial patterns of the 357 nuclei that could be faithfully segmented and annotated out of the 558 present at this developmental stage. We then developed an automated approach to assign cell names to each nucleus in a three-dimensional image of an L1 worm. We achieved 86% accuracy in identifying the 357 nuclei automatically. This computational method will allow high-throughput single-cell analyses of the post-embryonic worm, such as gene expression analysis, or ablation or stimulation of cells under computer control in a high-throughput functional screen.
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Fischler, M. A., & Bolles, R. C. (1981) · Communications of the ACM · doi:10.1145/358669.358692 · Cited by 25,893
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
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Peng, H., Ruan, Z., Long, F., Simpson, J. H., & Myers, E. W. (2010) · Nature Biotechnology · doi:10.1038/nbt.1612 · Cited by 707
Self-citationExtensible visualization and analysis for multidimensional images using Vaa3D
Peng, H., Bria, A., Zhou, Z., Iannello, G., & Long, F. (2014) · Nature Protocols · doi:10.1038/nprot.2014.011 · Cited by 315
Self-citationAn unbiased template of the Drosophila brain and ventral nerve cord
Bogovic, J. A., Otsuna, H., Heinrich, L., Ito, M., Jeter, J., Meissner, G., Nern, A., Colonell, J., Malkesman, O., Ito, K., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0236495 · Cited by 131
Volumetric Semantic Segmentation Using Pyramid Context Features
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Metadata
- Authors
- Long, F., Peng, H., Liu, X., Kim, S. K., & Myers, E.
- Venue
- Nature Methods
- Published
- 2009-08-16
- Volume
- 6
- Issue
- 9
- Pages
- 667-672
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2149404019
- Cited by
- 199
- References
- 3
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- green
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