The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Profiling metabolites and peptides in single cells
Open accessAbstract
The intracellular levels and spatial localizations of metabolites and peptides reflect the state of a cell and its relationship to its surrounding environment. Moreover, the amounts and dynamics of metabolites and peptides are indicative of normal or pathological cellular conditions. Here we highlight established and evolving strategies for characterizing the metabolome and peptidome of single cells. Focused studies of the chemical composition of individual cells and functionally defined groups of cells promise to provide a greater understanding of cell fate, function and homeostatic balance. Single-cell bioanalytical microanalysis has also become increasingly valuable for examining cellular heterogeneity, particularly in the fields of neuroscience, stem cell biology and developmental biology.
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Cites
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Cited by
Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
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Single-cell proteomics enabled by next-generation sequencing or mass spectrometry
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Metadata
- Authors
- Rubakhin, S. S., Romanova, E. V., Nemes, P., & Sweedler, J. V.
- Venue
- Nature Methods
- Published
- 2011-03-30
- Volume
- 8
- Issue
- S4
- Pages
- S20-S29
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2081412654
- Cited by
- 347
- References
- 80
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Rubakhin, S. S., Romanova, E. V., Nemes, P., & Sweedler, J. V. (2011). Profiling metabolites and peptides in single cells. Nature Methods. https://doi.org/10.1038/nmeth.1549
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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