A public genome-scale lentiviral expression library of human ORFs

Cited by (572)

Items 101–200 of 572

1. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer
   Sameer S. Bajikar, Chun‐Chao Wang, Michael A. Borten, Elizabeth J. Pereira, Kristen A. Atkins, Kevin A. Janes · 2017 · Developmental Cell
2. Functional annotation of rare gene aberration drivers of pancreatic cancer
   Yiu Huen Tsang, Turgut Dogruluk, Philip M. Tedeschi, Joanna Wardwell‐Ozgo, Hengyu Lu, Maribel Espitia, Nikitha V. Nair, Rosalba Minelli, Zechen Chong, Fengju Chen et al. · 2016 · Nature Communications
3. Oncogenic RIT1 mutations in lung adenocarcinoma
   Berger Ah, Marcin B. Imielinski, Fujiko F. Duke, Jeremiah A. Wala, Nathan O. Kaplan, Shi Gx, Douglas Andres, Matthew M. Meyerson · 2014 · Oncogene
4. Multiplex single-molecule interaction profiling of DNA-barcoded proteins
   Liangcai Gu, Chao Li, John Aach, DAVID EDWIN HILL, Marc Vidal, George McDonald Church · 2014 · Nature
5. Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells
   Ben P. Hung, Daphne L. Hutton, Kristen Kozielski, Corey J. Bishop, Bilal A. Naved, Jordan J. Green, Arnold I. Caplan, Jeffrey M. Gimble, Amir H. Dorafshar, Warren L. Grayson · 2015 · Stem Cells
6. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase
   Tsukasa Okiyoneda, Guido Veit, Ryohei Sakai, Misaki Aki, Takeshi Fujihara, Momoko Higashi, Seiko Susuki-Miyata, Masanori Miyata, Norihito Fukuda, Akihiko Yoshida et al. · 2018 · Developmental Cell
7. A multi-scale map of cell structure fusing protein images and interactions
   Qin, Yue, Huttlin, Edward L., Winsnes, Casper F., Gosztyla, Maya L., Wacheul, Ludivine, Kelly, Marcus R., Blue, Steven M., Zheng, Fan, Chen, Michael, Schaffer, Leah V. et al. · 2021 · Nature
8. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer
   S. Viswanathan, Marina F Nogueira, Colin G. Buss, J. Krill-Burger, M. Wawer, E. Małolepsza, Ashton C. Berger, P. Choi, Juliann Shih, Alison M. Taylor et al. · 2018 · Nature Genetics
9. Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogeneFNDC3B
   Chunlin Cai, Megha Rajaram, Xin Zhou, Qing Liu, John Marchica, Jinyu Li, Scott Powers · 2012 · Cell Cycle
10. RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis
    Peter S. Winter, Kristopher A. Sarosiek, Kevin Lin, Manja Meggendorfer, Susanne Schnittger, Anthony G. Letai, Kris C. Wood · 2014 · Science Signaling
11. Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer
    Supipi Duffy, Hok Khim Fam, Yi Kan Wang, Erin B. Styles, Jung‐Hyun Kim, J. Sidney Ang, Tejomayee Singh, Vladimir Larionov, Sohrab P. Shah, Brenda Andrews et al. · 2016 · Proceedings of the National Academy of Sciences
12. A Chemical Strategy for Protease Substrate Profiling
    Andrew R. Griswold, Paolo Cifani, Sahana D. Rao, Abram J. Axelrod, Matthew M. Miele, Ronald C. Hendrickson, Alex Kentsis, Daniel A. Bachovchin · 2019 · Cell chemical biology
13. Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase
    Steven F. Baker, Mitchell P. Ledwith, Andrew Mehle · 2018 · Cell Reports
14. MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer
    A. Augert, Haritha Mathsyaraja, A. Ibrahim, B. Freie, Michael Geuenich, Pei-Feng Cheng, Sydney P. Alibeckoff, N. Wu, J. Hiatt, Ryan S. Basom et al. · 2020 · Cancer Cell
15. Sources of Error in Mammalian Genetic Screens
    Sack, Laura Magill, Davoli, Teresa, Xu, Qikai, Li, Mamie Z, Elledge, Stephen J · 2016 · G3 Genes|Genomes|Genetics
16. A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
    Daniel A. Bachovchin, Luke W. Koblan, Wengen Wu, Yuxin Liu, Youhua Li, Peng Zhao, Iwona Woźnica, Ying Shu, Jack Hung-Sen Lai, Sarah E. Poplawski et al. · 2014 · Nature Chemical Biology
17. A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis
    Taha Azad, Kazem Nouri, Helena J. Janse van Rensburg, Sarah M. Maritan, Liqing Wu, Yawei Hao, Tess Montminy, Jihang Yu, Prem Khanal, Lois M. Mulligan et al. · 2019 · Oncogene
18. TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration and Invasion in Breast Cancer
    Hyeseung Lee, Hani Goodarzi, Sohail F. Tavazoie, Claudio R. Alarcón · 2016 · Cancer Research
19. Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential
    Mariana Reis-Sobreiro, Jie‐Fu Chen, Tatiana Novitskaya, Sungyong You, Samantha Morley, Kenneth Steadman, Navjot Kaur Gill, Adel Eskaros, Mirja Rotinen, Chia-Yi Chu et al. · 2018 · Cancer Research
20. Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies
    Chuanfeng Wu, So Gun Hong, Thomas Winkler, David M. Spencer, Alexander Jares, Brian Ichwan, Alina Nicolae, Vicky Guo, André Larochelle, Cynthia E. Dunbar · 2014 · Molecular Therapy — Methods & Clinical Development
21. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders
    Siwei Chen, Robert Fragoza, Lambertus Klei, Yuan Liu, Jiebiao Wang, Kathryn Roeder, Bernie Devlin, Haiyuan Yu · 2018 · Nature Genetics
22. The Potassium Channel, Kir3.4 Participates in Angiotensin II-Stimulated Aldosterone Production by a Human Adrenocortical Cell Line
    Kenji Oki, Maria W. Plonczynski, Milay Luis Lam, Elise P. Gómez-Sánchez, Celso E. Gómez-Sánchez · 2012 · Endocrinology
23. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
    Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Hua Liang, Tina N. Tran, Siqi Liang, Juan Felipe Beltrán, Christen A. Rivera-Erick, Kaixiong Ye, Ting‐Yi Wang et al. · 2019 · Nature Communications
24. Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer
    Daniel P. Bondeson, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Carly R. Langan, Gabriel Mesa, Alfredo E. Gonzalez, Lauren E. Surface, Kentaro Ito et al. · 2022 · Nature Cancer
25. Structural Insights into KCTD Protein Assembly and Cullin3 Recognition
    Alan X. Ji, Anh Chu, Tine Kragh Nielsen, Samir Benlekbir, John L. Rubinstein, Gilbert G. Privé · 2015 · Journal of Molecular Biology
26. Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
    Dariusz Ratman, Viacheslav Mylka, Nadia Bougarne, Michał Pawlak, Sandrine Caron, Nathalie Hennuyer, Réjane Paumelle, Lode De Cauwer, Jonathan Thommis, Mark H. Rider et al. · 2016 · Nucleic Acids Research
27. Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7
    Amandine Guérin, Nathan H. Roy, Emily M. Kugler, Laurence Berry, Janis K. Burkhardt, Jung‐Bum Shin, Boris Striepen · 2021 · Cell Host & Microbe
28. MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy
    Manish Neupane, Allison P. Clark, Serena Landini, Nicolai J. Birkbak, Aron Charles Eklund, Elgene Lim, Aedín C. Culhane, William Thomas Barry, Steven E. Schumacher, Rameen Beroukhim et al. · 2015 · Cancer Discovery
29. CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer
    Justin H. Hwang, Ji-Heui Seo, Michael L. Beshiri, Stephanie A. M. Wankowicz, David Liu, Alexander T. M. Cheung, Ji Li, Xintao Qiu, Andrew Lee Hong, Ginevra Botta et al. · 2019 · Cell Reports
30. Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia
    Sofie Peirs, Viktoras Frismantas, Filip Matthijssens, Wouter Van Loocke, Tim Pieters, Niels Vandamme, Béatrice Lintermans, Maria Pamela Dobay, Geert Berx, Bruce Graham Poppe et al. · 2017 · Leukemia
31. Systematic protein–protein interaction mapping for clinically relevant human GPCRs
    Kate Sokolina, Saranya Kittanakom, Jamie D. Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong et al. · 2017 · Molecular Systems Biology
32. Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants
    Akil Hamza, Erik Tammpere, Megan Kofoed, Christelle Keong, Jennifer Chiang, Guri N. Giaever, Corey Nislow, Philip Hieter · 2015 · Genetics
33. A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase
    Song Sun, Jochen Weile, Marta Verby, Yingzhou Wu, Yang Wang, Atina G. Coté, Iosifina Fotiadou, Julia Kitaygorodsky, Marc Vidal, Jasper Rine et al. · 2020 · Genome Medicine
34. Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex
    Román González‐Prieto, Karolin Eifler, Laura A. Claessens, Edwin Willemstein, Zhenyu Xiao, Cami M. P. Talavera Ormeño, Huib Ovaa, Helle D. Ulrich, Alfred C.O. Vertegaal · 2021 · Cell Reports
35. Genomics and the evolution of phenotypic traits
    Wray, Gregory A. · 2013 · Annual Review of Ecology, Evolution, and Systematics
36. The Interactome of the VAP Family of Proteins: An Overview
    Christina James, Ralph H. Kehlenbach · 2021 · Cells
37. Pervasive mislocalization of pathogenic coding variants underlying human disorders
    Jessica Lacoste, Marzieh Haghighi, Shahan Haider, Chloe Reno, Zhen‐Yuan Lin, Dmitri Segal, Wesley Wei Qian, Xueting Xiong, Tanisha Teelucksingh, Esteban Alberto Miglietta et al. · 2024 · Cell
38. Fanconi anemia protein FANCI functions in ribosome biogenesis
    Samuel B. Sondalle, Simonne Longerich, Lisa M. Ogawa, Patrick Sung, Susan J. Baserga · 2019 · Proceedings of the National Academy of Sciences
39. Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress
    Lindsey D. Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J. Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S. Ghaderpour Taleghani, Julie Jacquemyn et al. · 2024 · Nature Neuroscience
40. Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2
    Matthew Tegowski, Cheng Fan, Albert S. Baldwin · 2018 · Journal of Biological Chemistry
41. RAS–MAPK Reactivation Facilitates Acquired Resistance in FGFR1 -Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade
    Bruno Bockorny, Maria Rusan, Wankun Chen, Rachel G. Liao, Yvonne Y. Li, Federica Piccioni, Jun Wang, Li Tan, Aaron R. Thorner, Tianxia Li et al. · 2018 · Molecular Cancer Therapeutics
42. An ancestral mycobacterial effector promotes dissemination of infection
    Joseph W. Saelens, Mollie I. Sweeney, Gopinath Viswanathan, Ana M. Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, Rachel M. Cronin, Erika J. Hughes, W. Jared Brewer et al. · 2022 · Cell
43. In vivo functional screening for systems-level integrative cancer genomics
    Julia Weber, Christian Joerg Braun, Dieter Saur, Roland Rad · 2020 · Nature reviews. Cancer
44. Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries
    Joel J. Credle, Jonathan Gunn, Puwanat Sangkhapreecha, Daniel R. Monaco, Xuwen Alice Zheng, Hung-Ji Tsai, Azaan Wilbon, William R. Morgenlander, Andre T. Rastegar, Yi Wei Dong et al. · 2022 · Nature Biomedical Engineering
45. Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
    Hans-Heinrich Hoffmann, William M. Schneider, Vincent A. Blomen, Margaret A. Scull, Alain Hovnanian, Thijn R. Brummelkamp, Charles M. Rice · 2017 · Cell Host & Microbe
46. Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies
    Karin Hellner, Fabrizio Miranda, Donatien Chedom Fotso, Sandra Herrero‐González, Daniel M. Hayden, Rick G. Tearle, Mara Artibani, Eli M. Carrami, Ruth M. Williams, Kezia L. Gaitskell et al. · 2016 · EBioMedicine
47. Humanized yeast to model human biology, disease and evolution
    Aashiq Hussain Kachroo, Michelle Vandeloo, Brittany M. Greco, Mudabir Abdullah · 2022 · Disease Models & Mechanisms
48. CRISPR-Cas9 for medical genetic screens: applications and future perspectives
    Hui-Ying Xue, Li-Juan Ji, Ai-Mei Gao, Ping Liu, Jing-Dong He, Xiaojie Lu · 2015 · Journal of Medical Genetics
49. PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres
    Irida Kastrati, Emanuele Canestrari, Jonna M. Frasor · 2014 · Oncogene
50. Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives
    Robert F. Shearer, Darren N. Saunders · 2014 · Genes to Cells
51. Genome-wide screen of gamma-secretase–mediated intramembrane cleavage of receptor tyrosine kinases
    Johannes A. M. Merilahti, Veera K. Ojala, Anna M. Knittle, Arto Tapio Pulliainen, Klaus Elenius · 2017 · Molecular Biology of the Cell
52. Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
    Ye Chen, Liang Xu, Anand Mayakonda, Mo-Li Huang, Deepika Kanojia, Tuan Zea Tan, Pushkar Dakle, Ruby Yu‐Tong Lin, Xinyu Ke, JONATHAN W. SAID et al. · 2019 · Nature Communications
53. Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular physiology
    Christopher A. Werley, Stefano Boccardo, Alessandra Rigamonti, Emil M. Hansson, Adam E. Cohen · 2020 · Nature Communications
54. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
    Yiyan Zheng, Ritika Sethi, Lingegowda Selanere Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Eli M. Carrami, David Mannion, Fabrizio Miranda et al. · 2018 · Nature Communications
55. Exploring liver cancer biology through functional genetic screens
    Cun Wang, Ying Cao, Chen Guang Yang, René Bernards, Wenxin Qin · 2021 · Nature Reviews Gastroenterology & Hepatology
56. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins
    Eric M. Davis, Jihye Kim, Bridget L. Menasché, Jacob Sheppard, Xuedong Liu, Aik Choon Tan, Jingshi Shen · 2015 · Cell Reports
57. UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
    Michael G. Kemp, Laura A. Lindsey‐Boltz, Aziz Sancar · 2015 · Journal of Biological Chemistry
58. Virus-Host Interactions: From Unbiased Genetic Screens to Function
    Holly R. Ramage, Sara R. Cherry · 2015 · Annual Review of Virology
59. Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool
    Katherine F. Donovan, Mudra Hegde, Meagan E. Sullender, Emma W Vaimberg, Cory M. Johannessen, David E. Root, John G. Doench · 2017 · PLoS ONE
60. Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability
    William J. Olson, Bruno Martorelli Di Genova, Gina M. Gallego-López, Anthony R. Dawson, David Stevenson, Daniel Amador‐Noguez, Laura J. Knoll · 2020 · PLoS Pathogens
61. New Host Factors Important for Respiratory Syncytial Virus (RSV) Replication Revealed by a Novel Microfluidics Screen for Interactors of Matrix (M) Protein*
    Sarit Kipper, Samar Hamad, Leon Caly, Dorit Avrahami, Eran Bacharach, David A. Jans, Doron Gerber, Monika Bajorek · 2015 · Molecular & Cellular Proteomics
62. Interactome disassembly during apoptosis occurs independent of caspase cleavage
    Nichollas E. Scott, Lindsay D. Rogers, Anna Prudova, Nat F. Brown, Nikolaus Fortelny, Christopher M. Overall, Leonard J. Foster · 2017 · Molecular Systems Biology
63. Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis
    Philbert Lee, Shangwen Jiang, Yuanyuan Li, Jiping Yue, Xuewen Gou, Shaoyu Chen, Yingming Zhao, Markus Schöber, Minjia Tan, Xiaoyang Wu · 2017 · The EMBO Journal
64. Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration
    Ying-Tsen Tung, Kuan-Chih Peng, Yen‐Chung Chen, Ya-Ping Yen, Mien Chang, Sebastian Thams, Jun‐An Chen · 2019 · Cell stem cell
65. Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients
    Toni Michel Brand, Stefan Hartmann, Neil E. Bhola, Noah D. Peyser, Hua Li, Yan Zeng, Erin Isaacson Wechsler, Max V. Ranall, Sourav Bandyopadhyay, Umamaheswar Duvvuri et al. · 2016 · Clinical Cancer Research
66. An inter‐species protein–protein interaction network across vast evolutionary distance
    Quan Zhong, Samuel J. Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang et al. · 2016 · Molecular Systems Biology
67. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer
    Christina Vorvis, Maria Hatziapostolou, Swapna Mahurkar‐Joshi, Μαρίνα Κουτσιούμπα, Jennifer L. Williams, Timothy R. Donahue, George A. Poultsides, Guido Eibl, Dimitrios Iliopoulos · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
68. MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity
    Kumar Yugandhar, Ting‐Yi Wang, Alden King-Yung Leung, Michael Charles Lanz, Ievgen Motorykin, Jin Hua Liang, Elnur Elyar Shayhidin, Marcus Bustamante Smolka, Sheng Zhang, Haiyuan Yu · 2019 · Molecular & Cellular Proteomics
69. Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy
    Daniel K. Lester, Chase Burton, Alycia Gardner, Patrick Innamarato, Krithika Nandakumar Kodumudi, Qian Liu, Emma Adhikari, Qianqian Ming, Daniel B. Williamson, Dennie Tompers Frederick et al. · 2023 · Nature Cancer
70. CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma
    Lisa D. McKenzie, J.W. Leclair, Kayla N. Miller, Averey D. Strong, Hilda L. Chan, Edward L. Oates, Keith Lloyd Ligon, Cameron Walter Brennan, Milan G. Chheda · 2019 · Scientific Reports
71. Analysis of the Human Kinome and Phosphatome Reveals Diseased Signaling Networks Induced by Overexpression
    Xiao‐Kang Lun, Damian Szklarczyk, Attila Gábor, Nadine Dobberstein, Vito RT Zanotelli, Julio Sáez-Rodríguez, Christian von Mering, Bernd Bodenmiller · 2018 · Molecular Cell
72. Revealing protein-protein interactions at the transcriptome scale by sequencing
    Kara L. Johnson, Zhijie Qi, Zhangming Yan, Xingzhao Wen, Tri C. Nguyen, Kathia Zaleta-Rivera, Chien-Ju Chen, Xiaochen Fan, Kiran Sriram, Xueyi Wan et al. · 2021 · Molecular Cell
73. Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
    Florian A. Lempp, Franziska Schlund, Lisa Rieble, Lea Nußbaum, Corinna Link, Zhenfeng Zhang, Yi Ni, Stephan Urban · 2019 · Nature Communications
74. Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics
    Hankum Park, Frances V Hundley, Qing Yu, Katherine A. Overmyer, Dain R. Brademan, Lia R. Serrano, João A. Paulo, Julia C. Paoli, Sharan Swarup, Joshua J. Coon et al. · 2022 · Nature Communications
75. A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human Disease Mutations
    Xiaomu Wei, Jishnu Das, Robert Fragoza, Jin Hua Liang, Francisco Meirelles Bastos de Oliveira, Hao Ran Lee, Xiujuan Wang, Matthew E. Mort, Peter D. Stenson, D.N. Cooper et al. · 2014 · PLoS Genetics
76. Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer
    Stover, Elizabeth H., Baco, Maria B., Cohen, Ofir, Li, Yvonne Y., Christie, Elizabeth L., Bagul, Mukta, Goodale, Amy, Lee, Yenarae, Pantel, Sasha, Rees, Matthew G. et al. · 2019 · Molecular Cancer Research
77. A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma
    Tikvah K. Hayes, Flora Luo, Ofir Cohen, Amy B. Goodale, Yenarae Lee, Sasha Pantel, Mukta Bagul, Federica Piccioni, David E. Root, Levi A. Garraway et al. · 2019 · Cancer Research
78. Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery
    Sajedah M. Hindi, Michael J. Petrany, Elena Greenfeld, Leah C. Focke, A. Cramer, Michael A. Whitt, Ramzi J. Khairallah, Christopher W. Ward, Jeffrey S. Chamberlain, Vikram Prasad et al. · 2023 · Cell
79. Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
    Hector H. Huang, Ian Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam, Yu-Hsiu Tony Lin, Priya Choudhry, Margarette C. Mariano, Makeba Marcoulis, Chin Fen Teo et al. · 2020 · Nature Communications
80. Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
    Madhurima Dhara, José A. Matta, Min Lei, Daniel Knowland, Hong Ying Yu, Shenyan Gu, David S. Bredt · 2020 · Nature Communications
81. Multimodal cell maps as a foundation for structural and functional genomics
    Leah V. Schaffer, Mengzhou Hu, Gege Qian, Kyung‐Mee Moon, Abantika Pal, Neelesh Soni, Andrew P. Latham, Laura Pontano Vaites, Dorothy Tsai, Nicole M. Mattson et al. · 2025 · Nature
82. High‐throughput cloning and expression library creation for functional proteomics
    Fernanda Festa, Jason Steel, Xiaofang Bian, Joshua LaBaer · 2013 · PROTEOMICS
83. Genetic modifiers of EGFR dependence in non-small cell lung cancer
    Tanaz Sharifnia, Victor Rusu, Federica Piccioni, Mukta Bagul, Marcin B. Imielinski, Andrew D. Cherniack, Chandra Sekhar Pedamallu, Bang Wong, Frederick Hugh Wilson, Levi A. Garraway et al. · 2014 · Proceedings of the National Academy of Sciences
84. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization
    Chao Dai, Jonathan P. Rennhack, Taylor E. Arnoff, Maneesha Thaker, Scott T. Younger, John G. Doench, August Yue Huang, Annan Yang, Andrew J. Aguirre, Belinda Lei Wang et al. · 2021 · Cell Reports
85. Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
    Xianbing Zhu, Zheng Fu, Kendall Dutchak, Azadeh Arabzadeh, Simon Milette, Jutta Steinberger, Geneviève Morin, Anie Monast, Virginie Pilon, Tim Kong et al. · 2024 · Cancer Research
86. SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression
    Luca Braccioli, Stephin J. Vervoort, Gianmarco Puma, Cora H. A. Nijboer, Paul James Coffer · 2018 · Stem Cell Research
87. Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
    Hao Wang, Wei Hou, Aldeb Perera, Carlee Bettler, Jordan R. Beach, Xianzhong Ding, Jun Li, Mitchell F. Denning, Asha R. Dhanarajan, Scott J. Cotler et al. · 2021 · Cell Reports
88. Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
    Moiez Ali, Erin Kaltenbrun, Grace R. Anderson, Sarah Jo Stephens, Sabrina Arena, Alberto Bardelli, Christopher M. Counter, Kris C. Wood · 2017 · Nature Communications
89. In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene
    Gavin P. Dunn, Hiu Wing Cheung, Pankaj Kumar Agarwalla, Sapana R. Thomas, Yulia A. Zektser, Alison M. Karst, Jesse S. Boehm, Barbara A. Weir, Aaron M. Berlin, Lihua Zou et al. · 2014 · Proceedings of the National Academy of Sciences
90. Host–Pathogen Interaction Profiling Using Self-Assembling Human Protein Arrays
    Xiaobo Yu, Kimberly B. Decker, Kristi Barker, M. Ramona Neunuebel, Justin Saul, Morgan C. Graves, Nathan P. Westcott, Howard C. Hang, Joshua LaBaer, Ji Qiu et al. · 2015 · Journal of Proteome Research
91. Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry
    Xiao‐Kang Lun, Vito RT Zanotelli, James D. Wade, Denis Schapiro, Marco Tognetti, Nadine Dobberstein, Bernd Bodenmiller · 2017 · Nature Biotechnology
92. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
    Toni Michel Brand, Stefan Hartmann, Neil E. Bhola, Hua Li, Yan Zeng, Rachel A. O’Keefe, Max V. Ranall, Sourav Bandyopadhyay, Margaret Soucheray, Nevan J. Krogan et al. · 2018 · Cancer Research
93. In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
    Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, Maribel Mosqueda et al. · 2018 · Nature Communications
94. Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6
    Brianna E. Talbot, David H. Vandorpe, Brian R. Stotter, Seth L. Alper, Johannes S. Schlöndorff · 2019 · Journal of Biological Chemistry
95. Presence of SopE and mode of infection result in increasedSalmonella‐containing vacuole damage and cytosolic release during host cell infection by Salmonella enterica
    Jennifer Röder, Michael Hensel · 2019 · Cellular Microbiology
96. Omics and therapy – A basis for precision medicine
    Joseph P. Garay, Joe W. Gray · 2012 · Molecular Oncology
97. Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma
    Benjamin Frank Goeppert, Christina Ernst, Constance Regina Baer, Stephanie K. Roessler, Marcus Renner, Arianeb Mehrabi, Mohammadreza Hafezi, Anita Pathil, Arne Warth, Albrecht Stenzinger et al. · 2016 · Epigenetics
98. CoA synthase regulates mitotic fidelity via CBP-mediated acetylation
    Chao‐Chieh Lin, Mayumi Kitagawa, Xiaohu Tang, Ming-Hsin Hou, Jianli Wu, Dan Chen Qu, Vinayaka Srinivas, Xiaojing Liu, J. Will Thompson, Bernard Mathey-Prévôt et al. · 2018 · Nature Communications
99. Mutations in the exocyst component EXOC2 cause severe defects in human brain development
    Nicole J. Van Bergen, Syed Mukhtar Ahmed, Felicity A. Collins, Mark J. Cowley, Annalisa Vetro, Russell Clive Dale, Daniella Helena Hock, Christian R. de Caestecker, Minal Juliet Menezes, Sean Massey et al. · 2020 · The Journal of Experimental Medicine
100. E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance
     Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P. Nowak, Elisa Hahn, Eugenia V. Pankevich, Anna Koren, Stefan Kubicek, Eric S. Fischer et al. · 2023 · Journal of the American Chemical Society